Tags

Type your tag names separated by a space and hit enter

Effect of vitamin D, calcium and multiple micronutrient supplementation on vitamin D and bone status in Bangladeshi premenopausal garment factory workers with hypovitaminosis D: a double-blinded, randomised, placebo-controlled 1-year intervention.
Br J Nutr. 2010 Jul; 104(2):241-7.BJ

Abstract

Due to little outdoor activity and low dietary intake of vitamin D (VD), Bangladeshi low-income women are at risk for osteoporosis at an early age. The present study assessed the effect of VD, Ca and multiple micronutrient supplementation on VD and bone status in Bangladeshi young female garment factory workers. This placebo-controlled 1-year intervention randomly assigned 200 apparently healthy subjects (aged 16-36 years) to four groups: VD group, daily 10 microg VD; VD and Ca (VD-Ca) group, daily 10 microg VD+600 mg Ca; multiple micronutrient and Ca (MMN-Ca) group, 10 microg VD and other micronutrients+600 mg Ca; a placebo group. Serum 25-hydroxyvitamin D (S-25OHD), intact parathyroid hormone (S-iPTH), Ca, phosphate and alkaline phosphatase were measured. Bone mineral density and bone mineral content were measured by dual-energy X-ray absorptiometry. All measurements were made at baseline and at 12 months. Significantly (P < 0.001) higher S-25OHD concentrations were observed in the supplemented groups than in the placebo group after the intervention. Supplementation had an effect (P < 0.001) on S-iPTH in the VD-Ca and MMN-Ca groups compared with the placebo group. Bone mineral augmentation increased at the femur in the supplemented groups. Supplementation with VD-Ca should be recommended as a strategic option to reduce the risk of osteomalacia and osteoporosis in these subjects. MMN-Ca may have analogous positive health implications with additional non-skeletal benefits.

Authors+Show Affiliations

Calcium Research Unit, Division of Nutrition, Department of Applied Chemistry and Microbiology, PO Box 66, 00014 University of Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20193095

Citation

Islam, Md Zahirul, et al. "Effect of Vitamin D, Calcium and Multiple Micronutrient Supplementation On Vitamin D and Bone Status in Bangladeshi Premenopausal Garment Factory Workers With Hypovitaminosis D: a Double-blinded, Randomised, Placebo-controlled 1-year Intervention." The British Journal of Nutrition, vol. 104, no. 2, 2010, pp. 241-7.
Islam MZ, Shamim AA, Viljakainen HT, et al. Effect of vitamin D, calcium and multiple micronutrient supplementation on vitamin D and bone status in Bangladeshi premenopausal garment factory workers with hypovitaminosis D: a double-blinded, randomised, placebo-controlled 1-year intervention. Br J Nutr. 2010;104(2):241-7.
Islam, M. Z., Shamim, A. A., Viljakainen, H. T., Akhtaruzzaman, M., Jehan, A. H., Khan, H. U., Al-Arif, F. A., & Lamberg-Allardt, C. (2010). Effect of vitamin D, calcium and multiple micronutrient supplementation on vitamin D and bone status in Bangladeshi premenopausal garment factory workers with hypovitaminosis D: a double-blinded, randomised, placebo-controlled 1-year intervention. The British Journal of Nutrition, 104(2), 241-7. https://doi.org/10.1017/S0007114510000437
Islam MZ, et al. Effect of Vitamin D, Calcium and Multiple Micronutrient Supplementation On Vitamin D and Bone Status in Bangladeshi Premenopausal Garment Factory Workers With Hypovitaminosis D: a Double-blinded, Randomised, Placebo-controlled 1-year Intervention. Br J Nutr. 2010;104(2):241-7. PubMed PMID: 20193095.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of vitamin D, calcium and multiple micronutrient supplementation on vitamin D and bone status in Bangladeshi premenopausal garment factory workers with hypovitaminosis D: a double-blinded, randomised, placebo-controlled 1-year intervention. AU - Islam,Md Zahirul, AU - Shamim,Abu Ahmed, AU - Viljakainen,Heli T, AU - Akhtaruzzaman,Mohammad, AU - Jehan,Atia H, AU - Khan,Habib Ullah, AU - Al-Arif,Ferdaus Ahmad, AU - Lamberg-Allardt,Christel, Y1 - 2010/03/01/ PY - 2010/3/3/entrez PY - 2010/3/3/pubmed PY - 2010/8/10/medline SP - 241 EP - 7 JF - The British journal of nutrition JO - Br J Nutr VL - 104 IS - 2 N2 - Due to little outdoor activity and low dietary intake of vitamin D (VD), Bangladeshi low-income women are at risk for osteoporosis at an early age. The present study assessed the effect of VD, Ca and multiple micronutrient supplementation on VD and bone status in Bangladeshi young female garment factory workers. This placebo-controlled 1-year intervention randomly assigned 200 apparently healthy subjects (aged 16-36 years) to four groups: VD group, daily 10 microg VD; VD and Ca (VD-Ca) group, daily 10 microg VD+600 mg Ca; multiple micronutrient and Ca (MMN-Ca) group, 10 microg VD and other micronutrients+600 mg Ca; a placebo group. Serum 25-hydroxyvitamin D (S-25OHD), intact parathyroid hormone (S-iPTH), Ca, phosphate and alkaline phosphatase were measured. Bone mineral density and bone mineral content were measured by dual-energy X-ray absorptiometry. All measurements were made at baseline and at 12 months. Significantly (P < 0.001) higher S-25OHD concentrations were observed in the supplemented groups than in the placebo group after the intervention. Supplementation had an effect (P < 0.001) on S-iPTH in the VD-Ca and MMN-Ca groups compared with the placebo group. Bone mineral augmentation increased at the femur in the supplemented groups. Supplementation with VD-Ca should be recommended as a strategic option to reduce the risk of osteomalacia and osteoporosis in these subjects. MMN-Ca may have analogous positive health implications with additional non-skeletal benefits. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/20193095/Effect_of_vitamin_D_calcium_and_multiple_micronutrient_supplementation_on_vitamin_D_and_bone_status_in_Bangladeshi_premenopausal_garment_factory_workers_with_hypovitaminosis_D:_a_double_blinded_randomised_placebo_controlled_1_year_intervention_ L2 - https://www.cambridge.org/core/product/identifier/S0007114510000437/type/journal_article DB - PRIME DP - Unbound Medicine ER -