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Effects of cutaneous gastric electrical stimulation on gastric emptying and postprandial satiety and fullness in lean and obese subjects.
J Clin Gastroenterol. 2010 May-Jun; 44(5):335-9.JC

Abstract

GOALS

The aim of this study was to investigate the therapeutic potential of cutaneous gastric electrical stimulation (CGES) at a tachygastrial frequency for obesity.

BACKGROUND

Implantable gastric electrical stimulator has been proposed for the treatment of obesity and it has recently been reported that the gastric electrical stimulation at a tachygastrial frequency inhibits gastric motility.

STUDY METHODS

Ten lean and 10 obese healthy volunteers were studied in 3 randomized sessions: no CGES, CGES at the physiologic frequency (3 cycles/min), and CGES at tachygastrial frequency (12 cycles/min). Electrical stimulation was performed using sinusoidal waves. The protocol included the following sequence: 20-minute baseline, 30-minute CGES, 30-minute recording without CGES, 30-minute CGES, ingestion of a 500 kcal liquid meal, and 30-minute CGES. Gastric slow waves were recorded using cutaneous electrogastrography during the periods without CGES. Gastric emptying was assessed by ultrasound. Dyspeptic symptoms were recorded.

RESULTS

(1) The half-time of gastric emptying was longer with CGES at the tachygastrial frequency than CGES at the physiologic frequency in both lean subjects (75.0+/-16.5 min vs. 41.0+/-8.7 min, P<0.01) and obese subjects (64.1+/-13.3 min vs. 32.7+/-5.0 min, P<0.01). (2) Postprandial dyspeptic symptom score (mainly satiety and fullness) was significantly higher with CGES at the tachygastrial frequency than CGES at the physiologic frequency in both lean (3.2+/-1.47 vs. 1.7+/-0.94, P<0.01) and obese (3.9+/-1.89 vs. 1.8+/-1.15, P<0.01) subjects.

CONCLUSIONS

CGES at a tachygastrial frequency enhances postprandial fullness and satiety, and delays gastric emptying. Its therapeutic potential for obesity needs to be studied.

Authors+Show Affiliations

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

20195164

Citation

Wang, Jing, et al. "Effects of Cutaneous Gastric Electrical Stimulation On Gastric Emptying and Postprandial Satiety and Fullness in Lean and Obese Subjects." Journal of Clinical Gastroenterology, vol. 44, no. 5, 2010, pp. 335-9.
Wang J, Song J, Hou X, et al. Effects of cutaneous gastric electrical stimulation on gastric emptying and postprandial satiety and fullness in lean and obese subjects. J Clin Gastroenterol. 2010;44(5):335-9.
Wang, J., Song, J., Hou, X., Liu, J., & Chen, J. D. (2010). Effects of cutaneous gastric electrical stimulation on gastric emptying and postprandial satiety and fullness in lean and obese subjects. Journal of Clinical Gastroenterology, 44(5), 335-9. https://doi.org/10.1097/MCG.0b013e3181d34572
Wang J, et al. Effects of Cutaneous Gastric Electrical Stimulation On Gastric Emptying and Postprandial Satiety and Fullness in Lean and Obese Subjects. J Clin Gastroenterol. 2010 May-Jun;44(5):335-9. PubMed PMID: 20195164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of cutaneous gastric electrical stimulation on gastric emptying and postprandial satiety and fullness in lean and obese subjects. AU - Wang,Jing, AU - Song,Jun, AU - Hou,Xiaohua, AU - Liu,Jinsong, AU - Chen,Jiande D Z, PY - 2010/3/3/entrez PY - 2010/3/3/pubmed PY - 2010/8/4/medline SP - 335 EP - 9 JF - Journal of clinical gastroenterology JO - J Clin Gastroenterol VL - 44 IS - 5 N2 - GOALS: The aim of this study was to investigate the therapeutic potential of cutaneous gastric electrical stimulation (CGES) at a tachygastrial frequency for obesity. BACKGROUND: Implantable gastric electrical stimulator has been proposed for the treatment of obesity and it has recently been reported that the gastric electrical stimulation at a tachygastrial frequency inhibits gastric motility. STUDY METHODS: Ten lean and 10 obese healthy volunteers were studied in 3 randomized sessions: no CGES, CGES at the physiologic frequency (3 cycles/min), and CGES at tachygastrial frequency (12 cycles/min). Electrical stimulation was performed using sinusoidal waves. The protocol included the following sequence: 20-minute baseline, 30-minute CGES, 30-minute recording without CGES, 30-minute CGES, ingestion of a 500 kcal liquid meal, and 30-minute CGES. Gastric slow waves were recorded using cutaneous electrogastrography during the periods without CGES. Gastric emptying was assessed by ultrasound. Dyspeptic symptoms were recorded. RESULTS: (1) The half-time of gastric emptying was longer with CGES at the tachygastrial frequency than CGES at the physiologic frequency in both lean subjects (75.0+/-16.5 min vs. 41.0+/-8.7 min, P<0.01) and obese subjects (64.1+/-13.3 min vs. 32.7+/-5.0 min, P<0.01). (2) Postprandial dyspeptic symptom score (mainly satiety and fullness) was significantly higher with CGES at the tachygastrial frequency than CGES at the physiologic frequency in both lean (3.2+/-1.47 vs. 1.7+/-0.94, P<0.01) and obese (3.9+/-1.89 vs. 1.8+/-1.15, P<0.01) subjects. CONCLUSIONS: CGES at a tachygastrial frequency enhances postprandial fullness and satiety, and delays gastric emptying. Its therapeutic potential for obesity needs to be studied. SN - 1539-2031 UR - https://www.unboundmedicine.com/medline/citation/20195164/Effects_of_cutaneous_gastric_electrical_stimulation_on_gastric_emptying_and_postprandial_satiety_and_fullness_in_lean_and_obese_subjects_ L2 - https://doi.org/10.1097/MCG.0b013e3181d34572 DB - PRIME DP - Unbound Medicine ER -