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Two- and three-layer tablet drug delivery systems for oral sustained release of soluble and poorly soluble drugs.
Drug Dev Ind Pharm. 2010 Aug; 36(8):903-16.DD

Abstract

BACKGROUND

Multilayer tablets are gaining importance in oral sustained drug delivery. They consist of an active matrix core and one or more layers applied during tableting which may act as barriers and regulate drug release.

OBJECTIVE

To examine the release performance of two model drugs, diclofenac sodium and furosemide, from two- and three-layer drug delivery systems using as carriers hydrophilic swellable polymers, namely, Metolose, Polyox, Xantham gum, and an erodible material Gantrez.

RESULTS AND DISCUSSION

All prepared formulations demonstrated sustained release profiles. They also indicated that the carrier characteristics (particularly swelling-expansion, erosion-dissolution) and drug solubility in combination with tablet structure considerably influenced the performance of examined formulations as well as their mode and mechanisms of release. In general our findings show that the differences in drug release between the two- and three-layer tablets are small as it appears that two-layer tablets exhibit a slightly higher release. Because of its greater erosion Gantrez formulations displayed faster release relative to Xantham gum, as did Metolose formulations compared to Polyox formulations. A faster release rate was also noted with diclofenac formulations compared to those of furosemide because of diclofenac's higher solubility mainly seen at early time period.

CONCLUSIONS

All three-layer Gantrez tablets containing either diclofenac or furosemide and the two-layer furosemide formulation demonstrated a biphasic release. The above indicate that both structures may be used successfully for sustained release drug delivery. In addition the use of multilayer tablets, consisting of materials with suitable properties, may result in modulation of drug release.

Authors+Show Affiliations

Faculty of Pharmacy, Department of Pharmaceutical Technology, University of Athens, Athens, Greece. efentakis@pharm.uoa.grNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20196641

Citation

Efentakis, M, et al. "Two- and Three-layer Tablet Drug Delivery Systems for Oral Sustained Release of Soluble and Poorly Soluble Drugs." Drug Development and Industrial Pharmacy, vol. 36, no. 8, 2010, pp. 903-16.
Efentakis M, Naseef H, Vlachou M. Two- and three-layer tablet drug delivery systems for oral sustained release of soluble and poorly soluble drugs. Drug Dev Ind Pharm. 2010;36(8):903-16.
Efentakis, M., Naseef, H., & Vlachou, M. (2010). Two- and three-layer tablet drug delivery systems for oral sustained release of soluble and poorly soluble drugs. Drug Development and Industrial Pharmacy, 36(8), 903-16. https://doi.org/10.3109/03639040903585119
Efentakis M, Naseef H, Vlachou M. Two- and Three-layer Tablet Drug Delivery Systems for Oral Sustained Release of Soluble and Poorly Soluble Drugs. Drug Dev Ind Pharm. 2010;36(8):903-16. PubMed PMID: 20196641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two- and three-layer tablet drug delivery systems for oral sustained release of soluble and poorly soluble drugs. AU - Efentakis,M, AU - Naseef,H, AU - Vlachou,M, PY - 2010/3/4/entrez PY - 2010/3/4/pubmed PY - 2010/10/29/medline SP - 903 EP - 16 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 36 IS - 8 N2 - BACKGROUND: Multilayer tablets are gaining importance in oral sustained drug delivery. They consist of an active matrix core and one or more layers applied during tableting which may act as barriers and regulate drug release. OBJECTIVE: To examine the release performance of two model drugs, diclofenac sodium and furosemide, from two- and three-layer drug delivery systems using as carriers hydrophilic swellable polymers, namely, Metolose, Polyox, Xantham gum, and an erodible material Gantrez. RESULTS AND DISCUSSION: All prepared formulations demonstrated sustained release profiles. They also indicated that the carrier characteristics (particularly swelling-expansion, erosion-dissolution) and drug solubility in combination with tablet structure considerably influenced the performance of examined formulations as well as their mode and mechanisms of release. In general our findings show that the differences in drug release between the two- and three-layer tablets are small as it appears that two-layer tablets exhibit a slightly higher release. Because of its greater erosion Gantrez formulations displayed faster release relative to Xantham gum, as did Metolose formulations compared to Polyox formulations. A faster release rate was also noted with diclofenac formulations compared to those of furosemide because of diclofenac's higher solubility mainly seen at early time period. CONCLUSIONS: All three-layer Gantrez tablets containing either diclofenac or furosemide and the two-layer furosemide formulation demonstrated a biphasic release. The above indicate that both structures may be used successfully for sustained release drug delivery. In addition the use of multilayer tablets, consisting of materials with suitable properties, may result in modulation of drug release. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/20196641/Two__and_three_layer_tablet_drug_delivery_systems_for_oral_sustained_release_of_soluble_and_poorly_soluble_drugs_ L2 - https://www.tandfonline.com/doi/full/10.3109/03639040903585119 DB - PRIME DP - Unbound Medicine ER -