Tags

Type your tag names separated by a space and hit enter

Pegylated interferon plus optimized weight-based ribavirin dosing negate the influence of weight and body mass index on early viral kinetics and sustained virological response in chronic hepatitis C.
J Viral Hepat. 2010 Dec; 17(12):834-8.JV

Abstract

AIM

Elevated body mass index (BMI) in chronic hepatitis C (CHC) has been associated with reduced rates of sustained virological response (SVR). The aims of this study were to determine whether early viral kinetics (and subsequently SVR) are influenced by weight or BMI by measuring HCV RNA at week 4 using two PCR assays with differing sensitivities.

METHODS

Patients with CHC treated with peginterferon plus weight-based ribavirin were included in this retrospective study. Body mass index, pretreatment viral load, genotype and liver histology were abstracted from the clinical database. HCV RNA PCR (lower limit of detection (LLD) <50 IU/mL) at treatment week 4 and 6 months after completion of therapy were recorded to determine the presence of rapid virological response (RVR-50) and SVR, respectively. In those who achieved RVR-50, stored week 4 serum was retested using Taqman (LLD < 15 IU/mL, RVR-15).

RESULTS

Of 134 patients included (genotype 1 57%, BMI 26.7 ± 4.5 kg/m², ribavirin dose 13.9 ± 2.6 mg/kg/day), 59% achieved SVR. RVR-50 was observed in 39.6% and RVR-15 in 27.6%. Neither body weight nor BMI influenced RVR-50, RVR-15 or SVR. The positive predictive values (PPVs) of RVR-50 and RVR-15 for SVR were 88.7% and 97.3% (P = 0.23). RVR-50 and RVR-15 superceded genotype and viral load as the strongest independent predictors of SVR (OR 9.25 (1.9-45.11) and OR 30.74 (3.08-317.96), respectively).

CONCLUSIONS

RVR is the strongest predictor of SVR. Early viral kinetics is not influenced by body weight or BMI when weight-based ribavirin is prescribed.

Authors+Show Affiliations

Department of Medicine, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20196800

Citation

Pattullo, V, et al. "Pegylated Interferon Plus Optimized Weight-based Ribavirin Dosing Negate the Influence of Weight and Body Mass Index On Early Viral Kinetics and Sustained Virological Response in Chronic Hepatitis C." Journal of Viral Hepatitis, vol. 17, no. 12, 2010, pp. 834-8.
Pattullo V, Ravindran NC, Mazzulli T, et al. Pegylated interferon plus optimized weight-based ribavirin dosing negate the influence of weight and body mass index on early viral kinetics and sustained virological response in chronic hepatitis C. J Viral Hepat. 2010;17(12):834-8.
Pattullo, V., Ravindran, N. C., Mazzulli, T., Wong, D. K., & Heathcote, E. J. (2010). Pegylated interferon plus optimized weight-based ribavirin dosing negate the influence of weight and body mass index on early viral kinetics and sustained virological response in chronic hepatitis C. Journal of Viral Hepatitis, 17(12), 834-8. https://doi.org/10.1111/j.1365-2893.2010.01248.x
Pattullo V, et al. Pegylated Interferon Plus Optimized Weight-based Ribavirin Dosing Negate the Influence of Weight and Body Mass Index On Early Viral Kinetics and Sustained Virological Response in Chronic Hepatitis C. J Viral Hepat. 2010;17(12):834-8. PubMed PMID: 20196800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pegylated interferon plus optimized weight-based ribavirin dosing negate the influence of weight and body mass index on early viral kinetics and sustained virological response in chronic hepatitis C. AU - Pattullo,V, AU - Ravindran,N C, AU - Mazzulli,T, AU - Wong,D K H, AU - Heathcote,E J, PY - 2010/3/4/entrez PY - 2010/3/4/pubmed PY - 2011/3/17/medline SP - 834 EP - 8 JF - Journal of viral hepatitis JO - J. Viral Hepat. VL - 17 IS - 12 N2 - AIM: Elevated body mass index (BMI) in chronic hepatitis C (CHC) has been associated with reduced rates of sustained virological response (SVR). The aims of this study were to determine whether early viral kinetics (and subsequently SVR) are influenced by weight or BMI by measuring HCV RNA at week 4 using two PCR assays with differing sensitivities. METHODS: Patients with CHC treated with peginterferon plus weight-based ribavirin were included in this retrospective study. Body mass index, pretreatment viral load, genotype and liver histology were abstracted from the clinical database. HCV RNA PCR (lower limit of detection (LLD) <50 IU/mL) at treatment week 4 and 6 months after completion of therapy were recorded to determine the presence of rapid virological response (RVR-50) and SVR, respectively. In those who achieved RVR-50, stored week 4 serum was retested using Taqman (LLD < 15 IU/mL, RVR-15). RESULTS: Of 134 patients included (genotype 1 57%, BMI 26.7 ± 4.5 kg/m², ribavirin dose 13.9 ± 2.6 mg/kg/day), 59% achieved SVR. RVR-50 was observed in 39.6% and RVR-15 in 27.6%. Neither body weight nor BMI influenced RVR-50, RVR-15 or SVR. The positive predictive values (PPVs) of RVR-50 and RVR-15 for SVR were 88.7% and 97.3% (P = 0.23). RVR-50 and RVR-15 superceded genotype and viral load as the strongest independent predictors of SVR (OR 9.25 (1.9-45.11) and OR 30.74 (3.08-317.96), respectively). CONCLUSIONS: RVR is the strongest predictor of SVR. Early viral kinetics is not influenced by body weight or BMI when weight-based ribavirin is prescribed. SN - 1365-2893 UR - https://www.unboundmedicine.com/medline/citation/20196800/Pegylated_interferon_plus_optimized_weight_based_ribavirin_dosing_negate_the_influence_of_weight_and_body_mass_index_on_early_viral_kinetics_and_sustained_virological_response_in_chronic_hepatitis_C_ L2 - https://doi.org/10.1111/j.1365-2893.2010.01248.x DB - PRIME DP - Unbound Medicine ER -