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HLA-B27 polymorphism in patients with juvenile and adult-onset ankylosing spondylitis in Southern China.
Tissue Antigens. 2010 Jan; 75(1):56-60.TA

Abstract

Distribution of B27 subtypes in juvenile and adult-onset ankylosing spondylitis (JAS and AAS) in Southern China was studied. A total of 505 patients belonged to Han population were included (145 JAS and 360 AAS patients), and 1368 healthy individuals were included as controls. Human leukocyte antigen (HLA)-B27 typing was performed by Luminex liquid array combining polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) and/or serological method. HLA-B27 subtyping was performed by polymerase chain reaction-sequence specific primer (PCR-SSP). The sequence-based typing was performed for the B*2715 samples to verify the PCR-SSP results. HLA-B27 was presented in 453 of 505 patients (89.7%), compared with 74 of 1368 controls (5.41%). B*2704 subtype in AS group was significantly higher than controls and B*2705 subtype significantly lower. B*2715 and B*2702 were found in 1.32% and 0.66% of the B27-positive patients but none in controls, and there was no significant difference between either of them and controls. B27-positive patients were 134 (92.4%) in JAS group and 319 (88.6%) in AAS group. There was no significant difference for B27 subtypes distribution between JAS (B*2704, 05, 15) and AAS (B*2704, 05, 15, 02) groups. The frequency of B*2715 in two groups was 3 (2.24%) and 3 (0.94%), respectively. The onset age of three JAS patients carrying B*2715 was 5, 9 and 13 years old, respectively. Our results suggested that B*2704 was the predominant subtype in AS patients in Southern China. B*2715 was observed in AS group only and slightly more in JAS than in AAS, and the patients carrying this allele tended to have early onset, B*2715 may be disease-association subtype.

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Authors+Show Affiliations

Mou Y
Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Wu Z
No affiliation info available
Gu J
No affiliation info available
Liao Z
No affiliation info available
Lin Z
No affiliation info available
Wei Q
No affiliation info available
Huang J
No affiliation info available
Li Q
No affiliation info available

MeSH

AdolescentAdultAge of OnsetChildChinaGenetic Association StudiesGenetic Predisposition to DiseaseHLA-B27 AntigenHumansPolymorphism, GeneticSpondylitis, AnkylosingYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20196819

Citation

Mou, Y, et al. "HLA-B27 Polymorphism in Patients With Juvenile and Adult-onset Ankylosing Spondylitis in Southern China." Tissue Antigens, vol. 75, no. 1, 2010, pp. 56-60.
Mou Y, Wu Z, Gu J, et al. HLA-B27 polymorphism in patients with juvenile and adult-onset ankylosing spondylitis in Southern China. Tissue Antigens. 2010;75(1):56-60.
Mou, Y., Wu, Z., Gu, J., Liao, Z., Lin, Z., Wei, Q., Huang, J., & Li, Q. (2010). HLA-B27 polymorphism in patients with juvenile and adult-onset ankylosing spondylitis in Southern China. Tissue Antigens, 75(1), 56-60. https://doi.org/10.1111/j.1399-0039.2009.01406.x
Mou Y, et al. HLA-B27 Polymorphism in Patients With Juvenile and Adult-onset Ankylosing Spondylitis in Southern China. Tissue Antigens. 2010;75(1):56-60. PubMed PMID: 20196819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA-B27 polymorphism in patients with juvenile and adult-onset ankylosing spondylitis in Southern China. AU - Mou,Y, AU - Wu,Z, AU - Gu,J, AU - Liao,Z, AU - Lin,Z, AU - Wei,Q, AU - Huang,J, AU - Li,Q, PY - 2010/3/4/entrez PY - 2010/3/4/pubmed PY - 2010/8/6/medline SP - 56 EP - 60 JF - Tissue antigens JO - Tissue Antigens VL - 75 IS - 1 N2 - Distribution of B27 subtypes in juvenile and adult-onset ankylosing spondylitis (JAS and AAS) in Southern China was studied. A total of 505 patients belonged to Han population were included (145 JAS and 360 AAS patients), and 1368 healthy individuals were included as controls. Human leukocyte antigen (HLA)-B27 typing was performed by Luminex liquid array combining polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) and/or serological method. HLA-B27 subtyping was performed by polymerase chain reaction-sequence specific primer (PCR-SSP). The sequence-based typing was performed for the B*2715 samples to verify the PCR-SSP results. HLA-B27 was presented in 453 of 505 patients (89.7%), compared with 74 of 1368 controls (5.41%). B*2704 subtype in AS group was significantly higher than controls and B*2705 subtype significantly lower. B*2715 and B*2702 were found in 1.32% and 0.66% of the B27-positive patients but none in controls, and there was no significant difference between either of them and controls. B27-positive patients were 134 (92.4%) in JAS group and 319 (88.6%) in AAS group. There was no significant difference for B27 subtypes distribution between JAS (B*2704, 05, 15) and AAS (B*2704, 05, 15, 02) groups. The frequency of B*2715 in two groups was 3 (2.24%) and 3 (0.94%), respectively. The onset age of three JAS patients carrying B*2715 was 5, 9 and 13 years old, respectively. Our results suggested that B*2704 was the predominant subtype in AS patients in Southern China. B*2715 was observed in AS group only and slightly more in JAS than in AAS, and the patients carrying this allele tended to have early onset, B*2715 may be disease-association subtype. SN - 1399-0039 UR - https://www.unboundmedicine.com/medline/citation/20196819/HLA_B27_polymorphism_in_patients_with_juvenile_and_adult_onset_ankylosing_spondylitis_in_Southern_China_ L2 - https://doi.org/10.1111/j.1399-0039.2009.01406.x DB - PRIME DP - Unbound Medicine ER -