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Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women.

Abstract

BACKGROUND/OBJECTIVES

To examine the association between dietary calcium and vitamin D intake and cervical neoplasia risk, we conducted a case-control study.

SUBJECTS/METHODS

We selected 405 incident cervical neoplasias (333 invasive carcinomas and 72 cervical intraepithelial neoplasias grade III (CIN3)) and 2025 age-matched non-cancer controls. Dietary information was collected using a semiquantitative food-frequency questionnaire (FFQ). The effect on cervical neoplasia risk was evaluated using conditional logistic regression models.

RESULTS

The inverse association between invasive carcinoma and milk, yogurt and fish was observed. On the other hand, the marginally significant inverse association between CIN3 and tofu and green leafy vegetables was observed. Compared with the lowest quartile (Q1) of calcium intake, adjusted odds ratios (ORs) for each of the three upper quartiles (Q2, Q3 and Q4) on invasive carcinoma risk were 0.86 (95% confidence interval (CI) 0.63-1.17), 0.50 (95% CI 0.34-0.73) and 0.68 (95% CI 0.48-0.97), respectively (P for trend=0.004). However, no association between calcium and cancer risk was evident among CIN3 cases (P for trend=0.528). Vitamin D intake showed a similar inverse association (Q2: OR 1.03, 95% CI 0.74-1.44; Q3: OR 0.80, 95% CI 0.56-1.15; and Q4: OR 0.64, 95% CI 0.43-0.94; P for trend=0.013). Similar to calcium, no association between vitamin D intake among CIN3 was evident (P for trend=0.109). An inverse association with calcium was evident in women whose vitamin D intake was low. However, this combined effect was not significant (invasive carcinoma: interaction P=0.819; and CIN3: interaction P=0.101).

CONCLUSION

We found an inverse association between dietary calcium and vitamin D intake and cervical neoplasia risk among a group of Japanese women.

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  • Authors+Show Affiliations

    ,

    Deparment of Gynecology and Obstetrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.

    , , , , , , , , , ,

    Source

    MeSH

    Adult
    Animals
    Calcium
    Calcium, Dietary
    Case-Control Studies
    Cervical Intraepithelial Neoplasia
    Diet Surveys
    Female
    Humans
    Japan
    Logistic Models
    Middle Aged
    Milk
    Odds Ratio
    Risk Factors
    Seafood
    Soy Foods
    Surveys and Questionnaires
    Uterine Cervical Neoplasms
    Vegetables
    Vitamin D
    Vitamin D Deficiency
    Yogurt

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20197786

    Citation

    Hosono, S, et al. "Association Between Dietary Calcium and Vitamin D Intake and Cervical Carcinogenesis Among Japanese Women." European Journal of Clinical Nutrition, vol. 64, no. 4, 2010, pp. 400-9.
    Hosono S, Matsuo K, Kajiyama H, et al. Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women. Eur J Clin Nutr. 2010;64(4):400-9.
    Hosono, S., Matsuo, K., Kajiyama, H., Hirose, K., Suzuki, T., Kawase, T., ... Tanaka, H. (2010). Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women. European Journal of Clinical Nutrition, 64(4), pp. 400-9. doi:10.1038/ejcn.2010.28.
    Hosono S, et al. Association Between Dietary Calcium and Vitamin D Intake and Cervical Carcinogenesis Among Japanese Women. Eur J Clin Nutr. 2010;64(4):400-9. PubMed PMID: 20197786.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women. AU - Hosono,S, AU - Matsuo,K, AU - Kajiyama,H, AU - Hirose,K, AU - Suzuki,T, AU - Kawase,T, AU - Kidokoro,K, AU - Nakanishi,T, AU - Hamajima,N, AU - Kikkawa,F, AU - Tajima,K, AU - Tanaka,H, Y1 - 2010/03/03/ PY - 2010/3/4/entrez PY - 2010/3/4/pubmed PY - 2010/10/12/medline SP - 400 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 64 IS - 4 N2 - BACKGROUND/OBJECTIVES: To examine the association between dietary calcium and vitamin D intake and cervical neoplasia risk, we conducted a case-control study. SUBJECTS/METHODS: We selected 405 incident cervical neoplasias (333 invasive carcinomas and 72 cervical intraepithelial neoplasias grade III (CIN3)) and 2025 age-matched non-cancer controls. Dietary information was collected using a semiquantitative food-frequency questionnaire (FFQ). The effect on cervical neoplasia risk was evaluated using conditional logistic regression models. RESULTS: The inverse association between invasive carcinoma and milk, yogurt and fish was observed. On the other hand, the marginally significant inverse association between CIN3 and tofu and green leafy vegetables was observed. Compared with the lowest quartile (Q1) of calcium intake, adjusted odds ratios (ORs) for each of the three upper quartiles (Q2, Q3 and Q4) on invasive carcinoma risk were 0.86 (95% confidence interval (CI) 0.63-1.17), 0.50 (95% CI 0.34-0.73) and 0.68 (95% CI 0.48-0.97), respectively (P for trend=0.004). However, no association between calcium and cancer risk was evident among CIN3 cases (P for trend=0.528). Vitamin D intake showed a similar inverse association (Q2: OR 1.03, 95% CI 0.74-1.44; Q3: OR 0.80, 95% CI 0.56-1.15; and Q4: OR 0.64, 95% CI 0.43-0.94; P for trend=0.013). Similar to calcium, no association between vitamin D intake among CIN3 was evident (P for trend=0.109). An inverse association with calcium was evident in women whose vitamin D intake was low. However, this combined effect was not significant (invasive carcinoma: interaction P=0.819; and CIN3: interaction P=0.101). CONCLUSION: We found an inverse association between dietary calcium and vitamin D intake and cervical neoplasia risk among a group of Japanese women. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/20197786/Association_between_dietary_calcium_and_vitamin_D_intake_and_cervical_carcinogenesis_among_Japanese_women_ L2 - http://dx.doi.org/10.1038/ejcn.2010.28 DB - PRIME DP - Unbound Medicine ER -