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Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women.
Eur J Clin Nutr. 2010 Apr; 64(4):400-9.EJ

Abstract

BACKGROUND/OBJECTIVES

To examine the association between dietary calcium and vitamin D intake and cervical neoplasia risk, we conducted a case-control study.

SUBJECTS/METHODS

We selected 405 incident cervical neoplasias (333 invasive carcinomas and 72 cervical intraepithelial neoplasias grade III (CIN3)) and 2025 age-matched non-cancer controls. Dietary information was collected using a semiquantitative food-frequency questionnaire (FFQ). The effect on cervical neoplasia risk was evaluated using conditional logistic regression models.

RESULTS

The inverse association between invasive carcinoma and milk, yogurt and fish was observed. On the other hand, the marginally significant inverse association between CIN3 and tofu and green leafy vegetables was observed. Compared with the lowest quartile (Q1) of calcium intake, adjusted odds ratios (ORs) for each of the three upper quartiles (Q2, Q3 and Q4) on invasive carcinoma risk were 0.86 (95% confidence interval (CI) 0.63-1.17), 0.50 (95% CI 0.34-0.73) and 0.68 (95% CI 0.48-0.97), respectively (P for trend=0.004). However, no association between calcium and cancer risk was evident among CIN3 cases (P for trend=0.528). Vitamin D intake showed a similar inverse association (Q2: OR 1.03, 95% CI 0.74-1.44; Q3: OR 0.80, 95% CI 0.56-1.15; and Q4: OR 0.64, 95% CI 0.43-0.94; P for trend=0.013). Similar to calcium, no association between vitamin D intake among CIN3 was evident (P for trend=0.109). An inverse association with calcium was evident in women whose vitamin D intake was low. However, this combined effect was not significant (invasive carcinoma: interaction P=0.819; and CIN3: interaction P=0.101).

CONCLUSION

We found an inverse association between dietary calcium and vitamin D intake and cervical neoplasia risk among a group of Japanese women.

Authors+Show Affiliations

Deparment of Gynecology and Obstetrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20197786

Citation

Hosono, S, et al. "Association Between Dietary Calcium and Vitamin D Intake and Cervical Carcinogenesis Among Japanese Women." European Journal of Clinical Nutrition, vol. 64, no. 4, 2010, pp. 400-9.
Hosono S, Matsuo K, Kajiyama H, et al. Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women. Eur J Clin Nutr. 2010;64(4):400-9.
Hosono, S., Matsuo, K., Kajiyama, H., Hirose, K., Suzuki, T., Kawase, T., Kidokoro, K., Nakanishi, T., Hamajima, N., Kikkawa, F., Tajima, K., & Tanaka, H. (2010). Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women. European Journal of Clinical Nutrition, 64(4), 400-9. https://doi.org/10.1038/ejcn.2010.28
Hosono S, et al. Association Between Dietary Calcium and Vitamin D Intake and Cervical Carcinogenesis Among Japanese Women. Eur J Clin Nutr. 2010;64(4):400-9. PubMed PMID: 20197786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women. AU - Hosono,S, AU - Matsuo,K, AU - Kajiyama,H, AU - Hirose,K, AU - Suzuki,T, AU - Kawase,T, AU - Kidokoro,K, AU - Nakanishi,T, AU - Hamajima,N, AU - Kikkawa,F, AU - Tajima,K, AU - Tanaka,H, Y1 - 2010/03/03/ PY - 2010/3/4/entrez PY - 2010/3/4/pubmed PY - 2010/10/12/medline SP - 400 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 64 IS - 4 N2 - BACKGROUND/OBJECTIVES: To examine the association between dietary calcium and vitamin D intake and cervical neoplasia risk, we conducted a case-control study. SUBJECTS/METHODS: We selected 405 incident cervical neoplasias (333 invasive carcinomas and 72 cervical intraepithelial neoplasias grade III (CIN3)) and 2025 age-matched non-cancer controls. Dietary information was collected using a semiquantitative food-frequency questionnaire (FFQ). The effect on cervical neoplasia risk was evaluated using conditional logistic regression models. RESULTS: The inverse association between invasive carcinoma and milk, yogurt and fish was observed. On the other hand, the marginally significant inverse association between CIN3 and tofu and green leafy vegetables was observed. Compared with the lowest quartile (Q1) of calcium intake, adjusted odds ratios (ORs) for each of the three upper quartiles (Q2, Q3 and Q4) on invasive carcinoma risk were 0.86 (95% confidence interval (CI) 0.63-1.17), 0.50 (95% CI 0.34-0.73) and 0.68 (95% CI 0.48-0.97), respectively (P for trend=0.004). However, no association between calcium and cancer risk was evident among CIN3 cases (P for trend=0.528). Vitamin D intake showed a similar inverse association (Q2: OR 1.03, 95% CI 0.74-1.44; Q3: OR 0.80, 95% CI 0.56-1.15; and Q4: OR 0.64, 95% CI 0.43-0.94; P for trend=0.013). Similar to calcium, no association between vitamin D intake among CIN3 was evident (P for trend=0.109). An inverse association with calcium was evident in women whose vitamin D intake was low. However, this combined effect was not significant (invasive carcinoma: interaction P=0.819; and CIN3: interaction P=0.101). CONCLUSION: We found an inverse association between dietary calcium and vitamin D intake and cervical neoplasia risk among a group of Japanese women. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/20197786/Association_between_dietary_calcium_and_vitamin_D_intake_and_cervical_carcinogenesis_among_Japanese_women_ L2 - http://dx.doi.org/10.1038/ejcn.2010.28 DB - PRIME DP - Unbound Medicine ER -