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[Evaluation of percentage of lymphocytes B with expression of co-receptors CD 40, CD22 and CD72 in hypertrophied adenoid at children with otitis media with effusion].
Otolaryngol Pol. 2009 Nov-Dec; 63(6):504-8.OP

Abstract

INTRODUCTION

In hypertrophied adenoid lymphocytes B make up about 60% all lymphocytes. When the lymphocytes B come in interaction with antigens this membranes signal be passed through their receptor (BCR) to interior of cell. This signal affect modulation on gene expression, activation from which depends activation, anergy or apoptosis of lymphocyte B. Accompany BCR co-receptors regulate his functions influence stimulate or inhibitive. To the most important co-receptors stepping out on lymphocyte B belong: CD40, CD22, CD72.

AIM OF STUDY

The aim of study was evaluation of lymphocytes B (CD19) with co-expression with CD72 and CD40 receptors in hypertrophied adenoid with at children with otitis media with effusion.

MATERIAL

An investigation was executed in hypertrophied adenoids with or without otitis media with effusion.

METHODS

By flow cytometry percentage of lymphocytes B with co-receptors CD 40, CD22 and CD72 in was analyzed.

RESULTS

The percentages of CD19+CD72+ lymphocytes in the group of children with adenoid hypertrophy and exudative otitis media were lower as compared to the reference group. However, the percentages of CD19+CD22+, CD19+CD40+ in the study group was approximate to the reference group.

CONCLUSIONS

The lower percentage of lymphocytes B CD72 + near approximate percentages of lymphocytes B CD40+ and BCD22+ at children with otitis media with effusion can be the cause of incorrect humoral response in hypertrophied adenoid at children. Maybe it is cause reduced spontaneous production IgA and IgG through lymphocyte at children with otitis media with effusion.

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Authors+Show Affiliations

Wysocka J
Zakad Laboratoryjnej Diagnostyki Pediatrycznej Uniwersytetu Medycznego w Białymstoku.
Zelazowska-Rutkowska B
No affiliation info available
Ratomski K
No affiliation info available
Skotnicka B
No affiliation info available
Hassmann-Poznańska E
No affiliation info available

MeSH

AdenoidsAdolescentAntigens, CDAntigens, CD19Antigens, Differentiation, B-LymphocyteB-LymphocytesBiomarkersCD40 AntigensCase-Control StudiesChildChild, PreschoolFemaleHumansHypertrophyMaleOtitis Media with EffusionSeverity of Illness IndexSialic Acid Binding Ig-like Lectin 2Statistics, Nonparametric

Pub Type(s)

Journal Article

Language

pol

PubMed ID

20198985

Citation

Wysocka, Jolanta, et al. "[Evaluation of Percentage of Lymphocytes B With Expression of Co-receptors CD 40, CD22 and CD72 in Hypertrophied Adenoid at Children With Otitis Media With Effusion]." Otolaryngologia Polska = the Polish Otolaryngology, vol. 63, no. 6, 2009, pp. 504-8.
Wysocka J, Zelazowska-Rutkowska B, Ratomski K, et al. [Evaluation of percentage of lymphocytes B with expression of co-receptors CD 40, CD22 and CD72 in hypertrophied adenoid at children with otitis media with effusion]. Otolaryngol Pol. 2009;63(6):504-8.
Wysocka, J., Zelazowska-Rutkowska, B., Ratomski, K., Skotnicka, B., & Hassmann-Poznańska, E. (2009). [Evaluation of percentage of lymphocytes B with expression of co-receptors CD 40, CD22 and CD72 in hypertrophied adenoid at children with otitis media with effusion]. Otolaryngologia Polska = the Polish Otolaryngology, 63(6), 504-8. https://doi.org/10.1016/S0030-6657(09)70169-6
Wysocka J, et al. [Evaluation of Percentage of Lymphocytes B With Expression of Co-receptors CD 40, CD22 and CD72 in Hypertrophied Adenoid at Children With Otitis Media With Effusion]. Otolaryngol Pol. 2009 Nov-Dec;63(6):504-8. PubMed PMID: 20198985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Evaluation of percentage of lymphocytes B with expression of co-receptors CD 40, CD22 and CD72 in hypertrophied adenoid at children with otitis media with effusion]. AU - Wysocka,Jolanta, AU - Zelazowska-Rutkowska,Beata, AU - Ratomski,Karol, AU - Skotnicka,Bozena, AU - Hassmann-Poznańska,Elzbieta, PY - 2010/3/5/entrez PY - 2010/3/5/pubmed PY - 2010/4/10/medline SP - 504 EP - 8 JF - Otolaryngologia polska = The Polish otolaryngology JO - Otolaryngol Pol VL - 63 IS - 6 N2 - INTRODUCTION: In hypertrophied adenoid lymphocytes B make up about 60% all lymphocytes. When the lymphocytes B come in interaction with antigens this membranes signal be passed through their receptor (BCR) to interior of cell. This signal affect modulation on gene expression, activation from which depends activation, anergy or apoptosis of lymphocyte B. Accompany BCR co-receptors regulate his functions influence stimulate or inhibitive. To the most important co-receptors stepping out on lymphocyte B belong: CD40, CD22, CD72. AIM OF STUDY: The aim of study was evaluation of lymphocytes B (CD19) with co-expression with CD72 and CD40 receptors in hypertrophied adenoid with at children with otitis media with effusion. MATERIAL: An investigation was executed in hypertrophied adenoids with or without otitis media with effusion. METHODS: By flow cytometry percentage of lymphocytes B with co-receptors CD 40, CD22 and CD72 in was analyzed. RESULTS: The percentages of CD19+CD72+ lymphocytes in the group of children with adenoid hypertrophy and exudative otitis media were lower as compared to the reference group. However, the percentages of CD19+CD22+, CD19+CD40+ in the study group was approximate to the reference group. CONCLUSIONS: The lower percentage of lymphocytes B CD72 + near approximate percentages of lymphocytes B CD40+ and BCD22+ at children with otitis media with effusion can be the cause of incorrect humoral response in hypertrophied adenoid at children. Maybe it is cause reduced spontaneous production IgA and IgG through lymphocyte at children with otitis media with effusion. SN - 0030-6657 UR - https://www.unboundmedicine.com/medline/citation/20198985/[Evaluation_of_percentage_of_lymphocytes_B_with_expression_of_co_receptors_CD_40_CD22_and_CD72_in_hypertrophied_adenoid_at_children_with_otitis_media_with_effusion]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0030-6657(09)70169-6 DB - PRIME DP - Unbound Medicine ER -