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Iron status with different infant feeding regimens: relevance to screening and prevention of iron deficiency.
J Pediatr 1991; 118(5):687-92JPed

Abstract

The objective of this study was to evaluate the benefit of screening for anemia in infants in relation to their previous diet. The iron status of 854 nine-month-old infants on three different feeding regimens and on a regimen including iron dextran injection was determined by analysis of hemoglobin, serum ferritin, and erythrocyte protoporphyrin levels and of serum transferrin saturation. Infants were categorized as having iron deficiency if two or three of the three biochemical test results were abnormal and as having iron deficiency anemia if, in addition, the hemoglobin level was less than 110 gm/L. The prevalence of iron deficiency was highest in infants fed cow milk formula without added iron (37.5%), intermediate in the group fed human milk (26.5%), much lower in those fed cow milk formula with added iron (8.0%), and virtually absent in those injected with iron dextran (1.3%). The corresponding values for iron deficiency anemia were 20.2%, 14.7%, 0.6%, and 0%, respectively. The use of iron supplements is therefore justified in infants fed cow milk formula without added iron, even when there is no biochemical evidence of iron deficiency. The low prevalence of iron deficiency in the group fed iron-fortified formula appears to make it unnecessary to screen routinely for anemia in such infants. These results also support the recommendation that infants who are exclusively fed human milk for 9 months need an additional source of iron after about 6 months of age.

Authors+Show Affiliations

Instituto de Nutricion y Technologia de los Alimentos, Universidad de Chile, Santiago.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

2019922

Citation

Pizarro, F, et al. "Iron Status With Different Infant Feeding Regimens: Relevance to Screening and Prevention of Iron Deficiency." The Journal of Pediatrics, vol. 118, no. 5, 1991, pp. 687-92.
Pizarro F, Yip R, Dallman PR, et al. Iron status with different infant feeding regimens: relevance to screening and prevention of iron deficiency. J Pediatr. 1991;118(5):687-92.
Pizarro, F., Yip, R., Dallman, P. R., Olivares, M., Hertrampf, E., & Walter, T. (1991). Iron status with different infant feeding regimens: relevance to screening and prevention of iron deficiency. The Journal of Pediatrics, 118(5), pp. 687-92.
Pizarro F, et al. Iron Status With Different Infant Feeding Regimens: Relevance to Screening and Prevention of Iron Deficiency. J Pediatr. 1991;118(5):687-92. PubMed PMID: 2019922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron status with different infant feeding regimens: relevance to screening and prevention of iron deficiency. AU - Pizarro,F, AU - Yip,R, AU - Dallman,P R, AU - Olivares,M, AU - Hertrampf,E, AU - Walter,T, PY - 1991/5/1/pubmed PY - 1991/5/1/medline PY - 1991/5/1/entrez KW - Age Factors KW - Americas KW - Biology KW - Bottle Feeding KW - Breast Feeding KW - Chile KW - Demographic Factors KW - Developing Countries KW - Diet KW - Examinations And Diagnoses KW - Health KW - Hematological Effects KW - Hemic System KW - Hemoglobin Level--analysis KW - Infant KW - Infant Nutrition KW - Latin America KW - Measurement KW - Nutrition KW - Physiology KW - Population KW - Population Characteristics KW - Prevalence KW - Research Methodology KW - Risk Factors KW - Screening KW - Serum Iron Level--analysis KW - Serum Iron Level--complications KW - South America KW - Supplementary Feeding KW - Youth SP - 687 EP - 92 JF - The Journal of pediatrics JO - J. Pediatr. VL - 118 IS - 5 N2 - The objective of this study was to evaluate the benefit of screening for anemia in infants in relation to their previous diet. The iron status of 854 nine-month-old infants on three different feeding regimens and on a regimen including iron dextran injection was determined by analysis of hemoglobin, serum ferritin, and erythrocyte protoporphyrin levels and of serum transferrin saturation. Infants were categorized as having iron deficiency if two or three of the three biochemical test results were abnormal and as having iron deficiency anemia if, in addition, the hemoglobin level was less than 110 gm/L. The prevalence of iron deficiency was highest in infants fed cow milk formula without added iron (37.5%), intermediate in the group fed human milk (26.5%), much lower in those fed cow milk formula with added iron (8.0%), and virtually absent in those injected with iron dextran (1.3%). The corresponding values for iron deficiency anemia were 20.2%, 14.7%, 0.6%, and 0%, respectively. The use of iron supplements is therefore justified in infants fed cow milk formula without added iron, even when there is no biochemical evidence of iron deficiency. The low prevalence of iron deficiency in the group fed iron-fortified formula appears to make it unnecessary to screen routinely for anemia in such infants. These results also support the recommendation that infants who are exclusively fed human milk for 9 months need an additional source of iron after about 6 months of age. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/2019922/Iron_status_with_different_infant_feeding_regimens:_relevance_to_screening_and_prevention_of_iron_deficiency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(05)80027-7 DB - PRIME DP - Unbound Medicine ER -