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Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study.
BMC Med Genet 2010; 11:39BM

Abstract

BACKGROUND

Glucocorticoids have an important role in early growth and development. Glucocorticoid receptor gene polymorphisms have been identified that contribute to the variability in glucocorticoid sensitivity. We examined whether these glucocorticoid receptor gene polymorphisms are associated with growth in fetal and early postnatal life.

METHODS

This study was embedded in a population-based prospective cohort study from fetal life onwards. The studied glucocorticoid receptor gene polymorphisms included BclI (rs41423247), TthIIII (rs10052957), GR-9beta (rs6198), N363S (rs6195) and R23K (rs6789 and6190). Fetal growth was assessed by ultrasounds in second and third trimester of pregnancy. Anthropometric measurements in early childhood were performed at birth and at the ages of 6, 14 and 24 months postnatally. Analyses focused on weight, length and head circumference. Analyses were based on 2,414 healthy, Caucasian children.

RESULTS

Glucocorticoid receptor gene polymorphisms were not associated with fetal weight, birth weight and early postnatal weight. Also, no associations were found with length and head circumference. Neither were these polymorphisms associated with the risks of low birth weight or growth acceleration from birth to 24 months of age.

CONCLUSIONS

We found in a large population-based cohort no evidence for an effect of known glucocorticoid receptor gene polymorphisms on fetal and early postnatal growth characteristics. Further systematic searches for common genetic variants by means of genome-wide association studies will enable us to obtain a more complete understanding of what genes and polymorphisms are involved in growth in fetal life and infancy.

Authors+Show Affiliations

The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20199670

Citation

Geelhoed, Miranda J J., et al. "Glucocorticoid Receptor Gene Polymorphisms Do Not Affect Growth in Fetal and Early Postnatal Life. the Generation R Study." BMC Medical Genetics, vol. 11, 2010, p. 39.
Geelhoed MJ, Steegers EA, Koper JW, et al. Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study. BMC Med Genet. 2010;11:39.
Geelhoed, M. J., Steegers, E. A., Koper, J. W., van Rossum, E. F., Moll, H. A., Raat, H., ... Jaddoe, V. W. (2010). Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study. BMC Medical Genetics, 11, p. 39. doi:10.1186/1471-2350-11-39.
Geelhoed MJ, et al. Glucocorticoid Receptor Gene Polymorphisms Do Not Affect Growth in Fetal and Early Postnatal Life. the Generation R Study. BMC Med Genet. 2010 Mar 3;11:39. PubMed PMID: 20199670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study. AU - Geelhoed,Miranda J J, AU - Steegers,Eric A P, AU - Koper,Jan W, AU - van Rossum,Elisabeth F C, AU - Moll,Henriette A, AU - Raat,Hein, AU - Tiemeier,Henning, AU - Hofman,Albert, AU - Jaddoe,Vincent W V, Y1 - 2010/03/03/ PY - 2009/08/26/received PY - 2010/03/03/accepted PY - 2010/3/5/entrez PY - 2010/3/5/pubmed PY - 2010/5/25/medline SP - 39 EP - 39 JF - BMC medical genetics JO - BMC Med. Genet. VL - 11 N2 - BACKGROUND: Glucocorticoids have an important role in early growth and development. Glucocorticoid receptor gene polymorphisms have been identified that contribute to the variability in glucocorticoid sensitivity. We examined whether these glucocorticoid receptor gene polymorphisms are associated with growth in fetal and early postnatal life. METHODS: This study was embedded in a population-based prospective cohort study from fetal life onwards. The studied glucocorticoid receptor gene polymorphisms included BclI (rs41423247), TthIIII (rs10052957), GR-9beta (rs6198), N363S (rs6195) and R23K (rs6789 and6190). Fetal growth was assessed by ultrasounds in second and third trimester of pregnancy. Anthropometric measurements in early childhood were performed at birth and at the ages of 6, 14 and 24 months postnatally. Analyses focused on weight, length and head circumference. Analyses were based on 2,414 healthy, Caucasian children. RESULTS: Glucocorticoid receptor gene polymorphisms were not associated with fetal weight, birth weight and early postnatal weight. Also, no associations were found with length and head circumference. Neither were these polymorphisms associated with the risks of low birth weight or growth acceleration from birth to 24 months of age. CONCLUSIONS: We found in a large population-based cohort no evidence for an effect of known glucocorticoid receptor gene polymorphisms on fetal and early postnatal growth characteristics. Further systematic searches for common genetic variants by means of genome-wide association studies will enable us to obtain a more complete understanding of what genes and polymorphisms are involved in growth in fetal life and infancy. SN - 1471-2350 UR - https://www.unboundmedicine.com/medline/citation/20199670/Glucocorticoid_receptor_gene_polymorphisms_do_not_affect_growth_in_fetal_and_early_postnatal_life__The_Generation_R_Study_ L2 - https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-11-39 DB - PRIME DP - Unbound Medicine ER -