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[Measurement of eosinophils and interleukin-17 in nasopharyngeal secretions of children under 5 years old with wheezing].
Zhongguo Dang Dai Er Ke Za Zhi 2010; 12(2):113-6ZD

Abstract

OBJECTIVE

To study the value of eosinophils (EOS) and interleukin-17 (IL-17) in nasopharyngeal secretions in the evaluation of progress of wheezing in children under 5 years old.

METHODS

Fifty-three children under five years old who had recurrent wheezing were classified into two groups: wheezing group I with atopic body (n=27) and wheezing group II without atopic body (n=26). Twenty pre-surgical children with non-infectious disease were used as the control group. Nasopharyngeal secretions were collected. Inflammatory cells in nasopharyngeal secretions were counted under the microscope. IL-17 levels in supernatants were measured using ELISA.

RESULTS

EOS counts in nasopharyngeal secretions in wheezing group I were significantly higher than those in wheezing group II and the control group (p<0.05, p<0.01, respectively). There were no significant differences in EOS counts between wheezing II and the control groups. The IL-17 levels in both wheezing groups were significantly higher than those in the control group (p<0.01), and the wheezing group I had increased IL-17 levels than wheezing group II (1 474+/-974 pg/mL vs 788+/-132 pg/mL; p<0.05). The IL-17 level was positively correlated with the EOS counts in wheezing group I (r=0.62, p<0.05).

CONCLUSIONS

EOS counts and IL-17 levels in nasopharyngeal secretions may be used as indices for identifying the tendency to develop asthma in children under 5 years old with wheezing.

Authors+Show Affiliations

Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. wxf456@126.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

20199725

Citation

Wang, Xiu-Fang, et al. "[Measurement of Eosinophils and Interleukin-17 in Nasopharyngeal Secretions of Children Under 5 Years Old With Wheezing]." Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, vol. 12, no. 2, 2010, pp. 113-6.
Wang XF, Yang JL, Qiao JY, et al. [Measurement of eosinophils and interleukin-17 in nasopharyngeal secretions of children under 5 years old with wheezing]. Zhongguo Dang Dai Er Ke Za Zhi. 2010;12(2):113-6.
Wang, X. F., Yang, J. L., Qiao, J. Y., & Zhang, Y. L. (2010). [Measurement of eosinophils and interleukin-17 in nasopharyngeal secretions of children under 5 years old with wheezing]. Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 12(2), pp. 113-6.
Wang XF, et al. [Measurement of Eosinophils and Interleukin-17 in Nasopharyngeal Secretions of Children Under 5 Years Old With Wheezing]. Zhongguo Dang Dai Er Ke Za Zhi. 2010;12(2):113-6. PubMed PMID: 20199725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Measurement of eosinophils and interleukin-17 in nasopharyngeal secretions of children under 5 years old with wheezing]. AU - Wang,Xiu-Fang, AU - Yang,Jin-Ling, AU - Qiao,Jun-Ying, AU - Zhang,Yan-Li, PY - 2010/3/5/entrez PY - 2010/3/5/pubmed PY - 2010/5/19/medline SP - 113 EP - 6 JF - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics JO - Zhongguo Dang Dai Er Ke Za Zhi VL - 12 IS - 2 N2 - OBJECTIVE: To study the value of eosinophils (EOS) and interleukin-17 (IL-17) in nasopharyngeal secretions in the evaluation of progress of wheezing in children under 5 years old. METHODS: Fifty-three children under five years old who had recurrent wheezing were classified into two groups: wheezing group I with atopic body (n=27) and wheezing group II without atopic body (n=26). Twenty pre-surgical children with non-infectious disease were used as the control group. Nasopharyngeal secretions were collected. Inflammatory cells in nasopharyngeal secretions were counted under the microscope. IL-17 levels in supernatants were measured using ELISA. RESULTS: EOS counts in nasopharyngeal secretions in wheezing group I were significantly higher than those in wheezing group II and the control group (p<0.05, p<0.01, respectively). There were no significant differences in EOS counts between wheezing II and the control groups. The IL-17 levels in both wheezing groups were significantly higher than those in the control group (p<0.01), and the wheezing group I had increased IL-17 levels than wheezing group II (1 474+/-974 pg/mL vs 788+/-132 pg/mL; p<0.05). The IL-17 level was positively correlated with the EOS counts in wheezing group I (r=0.62, p<0.05). CONCLUSIONS: EOS counts and IL-17 levels in nasopharyngeal secretions may be used as indices for identifying the tendency to develop asthma in children under 5 years old with wheezing. SN - 1008-8830 UR - https://www.unboundmedicine.com/medline/citation/20199725/[Measurement_of_eosinophils_and_interleukin_17_in_nasopharyngeal_secretions_of_children_under_5_years_old_with_wheezing]_ L2 - http://www.cjcp.org/EN/abstract/abstract12183.shtml DB - PRIME DP - Unbound Medicine ER -