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Effect of soy isoflavone extract supplements on bone mineral density in menopausal women: meta-analysis of randomized controlled trials.

Abstract

This study was conducted to clarify the effect of ingesting soy isoflavone extracts (not soy protein or foods containing isoflavones) on bone mineral density (BMD) in menopausal women. PubMed, CENTRAL, ICHUSHI, CNKI, Wanfang Data, CQVIP, and NSTL were searched for randomized controlled trials published in English, Japanese, or Chinese reporting the effects of soy isoflavone extracts on lumbar spine or hip BMD in menopausal women. Trials were identified and reviewed for inclusion and exclusion eligibility. Data on study design, participants, interventions, and outcomes were extracted. Eleven, seven, five, and five trials were finally selected for estimation of the effects on spine, femoral neck, hip total, and trochanter BMD, respectively. Meta-analysis including data from1240 menopausal women revealed that daily ingestion of an average of 82 (47-150) mg soy isoflavones (aglycone equivalent) for 6-12 months significantly increased spine BMD by 22.25 mg/cm2 (95% CI: 7.62, 32.89; p=0.002), or by 2.38% (95% CI: 0.93, 3.83; p=0.001) compared with controls (random-effects model). Subgroup analyses indicated that the varying effects of isoflavones on spine BMD across trials might be associated with study characteristics of intervention duration (6 vs. 12 months), region of participant (Asian vs. Western), and basal BMD (normal bone mass vs. osteopenia or osteoporosis). No significant effects on femoral neck, hip total, and trochanter BMD were found. Soy isoflavone extract supplements increased lumbar spine BMD in menopausal women. Further studies are needed to address factors affecting the magnitudes of effect on spine and to verify the effect on hip.

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  • Authors+Show Affiliations

    ,

    Information Center, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8636, Japan. takuk@nih.go.jp

    , , , , ,

    Source

    MeSH

    Absorptiometry, Photon
    Bone Density
    Bone Diseases, Metabolic
    Dietary Supplements
    Female
    Femur
    Femur Neck
    Hip
    Humans
    Isoflavones
    Lumbar Vertebrae
    Middle Aged
    Osteoporosis, Postmenopausal
    Pelvic Bones
    Perimenopause
    Phytotherapy
    Plant Extracts
    Randomized Controlled Trials as Topic
    Soybeans

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20199985

    Citation

    Taku, Kyoko, et al. "Effect of Soy Isoflavone Extract Supplements On Bone Mineral Density in Menopausal Women: Meta-analysis of Randomized Controlled Trials." Asia Pacific Journal of Clinical Nutrition, vol. 19, no. 1, 2010, pp. 33-42.
    Taku K, Melby MK, Takebayashi J, et al. Effect of soy isoflavone extract supplements on bone mineral density in menopausal women: meta-analysis of randomized controlled trials. Asia Pac J Clin Nutr. 2010;19(1):33-42.
    Taku, K., Melby, M. K., Takebayashi, J., Mizuno, S., Ishimi, Y., Omori, T., & Watanabe, S. (2010). Effect of soy isoflavone extract supplements on bone mineral density in menopausal women: meta-analysis of randomized controlled trials. Asia Pacific Journal of Clinical Nutrition, 19(1), pp. 33-42.
    Taku K, et al. Effect of Soy Isoflavone Extract Supplements On Bone Mineral Density in Menopausal Women: Meta-analysis of Randomized Controlled Trials. Asia Pac J Clin Nutr. 2010;19(1):33-42. PubMed PMID: 20199985.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of soy isoflavone extract supplements on bone mineral density in menopausal women: meta-analysis of randomized controlled trials. AU - Taku,Kyoko, AU - Melby,Melissa K, AU - Takebayashi,Jun, AU - Mizuno,Shoichi, AU - Ishimi,Yoshiko, AU - Omori,Toyonori, AU - Watanabe,Shaw, PY - 2010/3/5/entrez PY - 2010/3/5/pubmed PY - 2010/5/12/medline SP - 33 EP - 42 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 19 IS - 1 N2 - This study was conducted to clarify the effect of ingesting soy isoflavone extracts (not soy protein or foods containing isoflavones) on bone mineral density (BMD) in menopausal women. PubMed, CENTRAL, ICHUSHI, CNKI, Wanfang Data, CQVIP, and NSTL were searched for randomized controlled trials published in English, Japanese, or Chinese reporting the effects of soy isoflavone extracts on lumbar spine or hip BMD in menopausal women. Trials were identified and reviewed for inclusion and exclusion eligibility. Data on study design, participants, interventions, and outcomes were extracted. Eleven, seven, five, and five trials were finally selected for estimation of the effects on spine, femoral neck, hip total, and trochanter BMD, respectively. Meta-analysis including data from1240 menopausal women revealed that daily ingestion of an average of 82 (47-150) mg soy isoflavones (aglycone equivalent) for 6-12 months significantly increased spine BMD by 22.25 mg/cm2 (95% CI: 7.62, 32.89; p=0.002), or by 2.38% (95% CI: 0.93, 3.83; p=0.001) compared with controls (random-effects model). Subgroup analyses indicated that the varying effects of isoflavones on spine BMD across trials might be associated with study characteristics of intervention duration (6 vs. 12 months), region of participant (Asian vs. Western), and basal BMD (normal bone mass vs. osteopenia or osteoporosis). No significant effects on femoral neck, hip total, and trochanter BMD were found. Soy isoflavone extract supplements increased lumbar spine BMD in menopausal women. Further studies are needed to address factors affecting the magnitudes of effect on spine and to verify the effect on hip. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/20199985/Effect_of_soy_isoflavone_extract_supplements_on_bone_mineral_density_in_menopausal_women:_meta_analysis_of_randomized_controlled_trials_ L2 - http://apjcn.nhri.org.tw/server/APJCN/19/1/33.pdf DB - PRIME DP - Unbound Medicine ER -