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Folate intake associated with lung function, breathlessness and the prevalence of chronic obstructive pulmonary disease.
Asia Pac J Clin Nutr. 2010; 19(1):103-9.AP

Abstract

A case-control study was conducted in central Japan to investigate the relationship between dietary intake of folate and lung function, breathlessness and chronic obstructive pulmonary disease (COPD). A total of 278 referred patients (244 men and 34 women) aged 50-75 years with COPD diagnosed within the past four years and 340 community-based controls (272 men and 68 women) were assessed for dyspnoea and undertook spirometric measurements of lung function. A structured questionnaire was administered face-to-face to obtain information on demographics, lifestyle and habitual food consumption. Folate intake was derived from the Japanese food composition tables. The COPD patients had significantly lower habitual intake of folate (mean 231, SD 90 microg/day) than control subjects (mean 261, SD 110 microg/day), p<0.001. Lung function measures were found to be positively associated with dietary folate level. Reductions in prevalence of COPD and especially breathlessness were observed, the respective adjusted odds ratio (OR) being 0.74 (95% confidence interval (CI) 0.35 to 1.58) and 0.43 (95% CI 0.21 to 0.91) for the highest versus lowest quartile of folate intake. The corresponding tests for linear trend were also significant (p<0.05). In conclusion, an inverse association was evident between dietary folate intake and the prevalence of breathlessness for Japanese adults, together with a significant dose-response relationship for the COPD risk. Moreover, increased folate intake might be beneficial to lung function.

Authors+Show Affiliations

School of Public Health, Curtin Health Innovation Research Institute, Curtin University of Technology, Perth, WA, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20199994

Citation

Hirayama, Fumi, et al. "Folate Intake Associated With Lung Function, Breathlessness and the Prevalence of Chronic Obstructive Pulmonary Disease." Asia Pacific Journal of Clinical Nutrition, vol. 19, no. 1, 2010, pp. 103-9.
Hirayama F, Lee AH, Terasawa K, et al. Folate intake associated with lung function, breathlessness and the prevalence of chronic obstructive pulmonary disease. Asia Pac J Clin Nutr. 2010;19(1):103-9.
Hirayama, F., Lee, A. H., Terasawa, K., & Kagawa, Y. (2010). Folate intake associated with lung function, breathlessness and the prevalence of chronic obstructive pulmonary disease. Asia Pacific Journal of Clinical Nutrition, 19(1), 103-9.
Hirayama F, et al. Folate Intake Associated With Lung Function, Breathlessness and the Prevalence of Chronic Obstructive Pulmonary Disease. Asia Pac J Clin Nutr. 2010;19(1):103-9. PubMed PMID: 20199994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate intake associated with lung function, breathlessness and the prevalence of chronic obstructive pulmonary disease. AU - Hirayama,Fumi, AU - Lee,Andy H, AU - Terasawa,Koji, AU - Kagawa,Yasuo, PY - 2010/3/5/entrez PY - 2010/3/5/pubmed PY - 2010/5/12/medline SP - 103 EP - 9 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 19 IS - 1 N2 - A case-control study was conducted in central Japan to investigate the relationship between dietary intake of folate and lung function, breathlessness and chronic obstructive pulmonary disease (COPD). A total of 278 referred patients (244 men and 34 women) aged 50-75 years with COPD diagnosed within the past four years and 340 community-based controls (272 men and 68 women) were assessed for dyspnoea and undertook spirometric measurements of lung function. A structured questionnaire was administered face-to-face to obtain information on demographics, lifestyle and habitual food consumption. Folate intake was derived from the Japanese food composition tables. The COPD patients had significantly lower habitual intake of folate (mean 231, SD 90 microg/day) than control subjects (mean 261, SD 110 microg/day), p<0.001. Lung function measures were found to be positively associated with dietary folate level. Reductions in prevalence of COPD and especially breathlessness were observed, the respective adjusted odds ratio (OR) being 0.74 (95% confidence interval (CI) 0.35 to 1.58) and 0.43 (95% CI 0.21 to 0.91) for the highest versus lowest quartile of folate intake. The corresponding tests for linear trend were also significant (p<0.05). In conclusion, an inverse association was evident between dietary folate intake and the prevalence of breathlessness for Japanese adults, together with a significant dose-response relationship for the COPD risk. Moreover, increased folate intake might be beneficial to lung function. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/20199994/Folate_intake_associated_with_lung_function_breathlessness_and_the_prevalence_of_chronic_obstructive_pulmonary_disease_ L2 - http://apjcn.nhri.org.tw/server/APJCN/19/1/103.pdf DB - PRIME DP - Unbound Medicine ER -