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Bioconversion of dietary provitamin A carotenoids to vitamin A in humans.
Am J Clin Nutr. 2010 May; 91(5):1468S-1473S.AJ

Abstract

Recent progress in the measurement of the bioconversion of dietary provitamin A carotenoids to vitamin A is reviewed in this article. Methods to assess the bioavailability and bioconversion of provitamin A carotenoids have advanced significantly in the past 10 y, specifically through the use of stable isotope methodology, which includes the use of labeled plant foods. The effects of the food matrix on the bioconversion of provitamin A carotenoids to vitamin A, dietary fat effects, and the effect of genotype on the absorption and metabolism of beta-carotene have been reported recently. A summary of the major human studies that determined conversion factors for dietary beta-carotene to retinol is presented here, and these data show that the conversion efficiency of dietary beta-carotene to retinol is in the range of 3.6-28:1 by weight. There is a wide variation in conversion factors reported not only between different studies but also between individuals in a particular study. These findings show that the vitamin A value of individual plant foods rich in provitamin A carotenoids may vary significantly and need further investigation.

Authors+Show Affiliations

Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. guangwen.tang@tufts.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

20200262

Citation

Tang, Guangwen. "Bioconversion of Dietary Provitamin a Carotenoids to Vitamin a in Humans." The American Journal of Clinical Nutrition, vol. 91, no. 5, 2010, 1468S-1473S.
Tang G. Bioconversion of dietary provitamin A carotenoids to vitamin A in humans. Am J Clin Nutr. 2010;91(5):1468S-1473S.
Tang, G. (2010). Bioconversion of dietary provitamin A carotenoids to vitamin A in humans. The American Journal of Clinical Nutrition, 91(5), 1468S-1473S. https://doi.org/10.3945/ajcn.2010.28674G
Tang G. Bioconversion of Dietary Provitamin a Carotenoids to Vitamin a in Humans. Am J Clin Nutr. 2010;91(5):1468S-1473S. PubMed PMID: 20200262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioconversion of dietary provitamin A carotenoids to vitamin A in humans. A1 - Tang,Guangwen, Y1 - 2010/03/03/ PY - 2010/3/5/entrez PY - 2010/3/5/pubmed PY - 2010/5/29/medline SP - 1468S EP - 1473S JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 91 IS - 5 N2 - Recent progress in the measurement of the bioconversion of dietary provitamin A carotenoids to vitamin A is reviewed in this article. Methods to assess the bioavailability and bioconversion of provitamin A carotenoids have advanced significantly in the past 10 y, specifically through the use of stable isotope methodology, which includes the use of labeled plant foods. The effects of the food matrix on the bioconversion of provitamin A carotenoids to vitamin A, dietary fat effects, and the effect of genotype on the absorption and metabolism of beta-carotene have been reported recently. A summary of the major human studies that determined conversion factors for dietary beta-carotene to retinol is presented here, and these data show that the conversion efficiency of dietary beta-carotene to retinol is in the range of 3.6-28:1 by weight. There is a wide variation in conversion factors reported not only between different studies but also between individuals in a particular study. These findings show that the vitamin A value of individual plant foods rich in provitamin A carotenoids may vary significantly and need further investigation. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20200262/Bioconversion_of_dietary_provitamin_A_carotenoids_to_vitamin_A_in_humans_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2010.28674G DB - PRIME DP - Unbound Medicine ER -