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[In vitro antibiotic susceptibility compliance with efficacy of chemotherapy in infections due to pathogenic Burkholderias].
Antibiot Khimioter. 2009; 54(7-8):19-23.AK

Abstract

Among the known species of Burkholderia only two are obligate pathogens, i.e., B. mallei and B. pseudomallei, causative agents of glanders and melioidosis respectively. The other species are saprophytes as natural inhabitants of water reservoirs and soil, still capable of causing opportunistic infections in humans and animals under definite conditions. All the species of Burkholderia are characterized by high resistance to antibacterials, including antibiotics. By the MICs, the most efficient chemotherapeutics against pathogenic burkholderias are tetracyclines, fluoroquinolones, penems and combined sulfanilamides. In the treatment of experimental glanders and melioidosis the set of the effective drugs had the inverse variation dependence on the infection severity and the desease process rate. Co-trimoxasole showed the best results, then followed doxicycline, ciprofioxacin and ceftazidime in the diminishing succession. The modification of the method for determination of antibiotic susceptibility with addition of native blood to the medium and the subculture under the atmosphere of 5% CO2 was shown useful in estimation of the prospects of the use of chemotherapeutics for the treatment of Burkholderia infections.

Authors

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Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

rus

PubMed ID

20201399

Citation

Iliukhin, V I., et al. "[In Vitro Antibiotic Susceptibility Compliance With Efficacy of Chemotherapy in Infections Due to Pathogenic Burkholderias]." Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [sic], vol. 54, no. 7-8, 2009, pp. 19-23.
Iliukhin VI, Senina TV, Trushkina MN, et al. [In vitro antibiotic susceptibility compliance with efficacy of chemotherapy in infections due to pathogenic Burkholderias]. Antibiot Khimioter. 2009;54(7-8):19-23.
Iliukhin, V. I., Senina, T. V., Trushkina, M. N., Shubnikova, E. V., Antonov, I. u. V., & Andropova, N. V. (2009). [In vitro antibiotic susceptibility compliance with efficacy of chemotherapy in infections due to pathogenic Burkholderias]. Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [sic], 54(7-8), 19-23.
Iliukhin VI, et al. [In Vitro Antibiotic Susceptibility Compliance With Efficacy of Chemotherapy in Infections Due to Pathogenic Burkholderias]. Antibiot Khimioter. 2009;54(7-8):19-23. PubMed PMID: 20201399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [In vitro antibiotic susceptibility compliance with efficacy of chemotherapy in infections due to pathogenic Burkholderias]. AU - Iliukhin,V I, AU - Senina,T V, AU - Trushkina,M N, AU - Shubnikova,E V, AU - Antonov,Iu V, AU - Andropova,N V, PY - 2010/3/6/entrez PY - 2009/1/1/pubmed PY - 2010/4/7/medline SP - 19 EP - 23 JF - Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] JO - Antibiot Khimioter VL - 54 IS - 7-8 N2 - Among the known species of Burkholderia only two are obligate pathogens, i.e., B. mallei and B. pseudomallei, causative agents of glanders and melioidosis respectively. The other species are saprophytes as natural inhabitants of water reservoirs and soil, still capable of causing opportunistic infections in humans and animals under definite conditions. All the species of Burkholderia are characterized by high resistance to antibacterials, including antibiotics. By the MICs, the most efficient chemotherapeutics against pathogenic burkholderias are tetracyclines, fluoroquinolones, penems and combined sulfanilamides. In the treatment of experimental glanders and melioidosis the set of the effective drugs had the inverse variation dependence on the infection severity and the desease process rate. Co-trimoxasole showed the best results, then followed doxicycline, ciprofioxacin and ceftazidime in the diminishing succession. The modification of the method for determination of antibiotic susceptibility with addition of native blood to the medium and the subculture under the atmosphere of 5% CO2 was shown useful in estimation of the prospects of the use of chemotherapeutics for the treatment of Burkholderia infections. SN - 0235-2990 UR - https://www.unboundmedicine.com/medline/citation/20201399/[In_vitro_antibiotic_susceptibility_compliance_with_efficacy_of_chemotherapy_in_infections_due_to_pathogenic_Burkholderias]_ L2 - https://medlineplus.gov/antibioticresistance.html DB - PRIME DP - Unbound Medicine ER -