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Combined effects of smoking and systolic blood pressure on risk of coronary heart disease: a cohort study in Chinese women.
J Womens Health (Larchmt) 2010; 19(4):713-8JW

Abstract

OBJECTIVES

To quantify the combined effects of systolic blood pressure (SBP) and cigarette smoking on incident coronary heart disease (CHD) in women.

METHODS

Overall, 86,338 women aged >or=40 years were enrolled in 1991. The follow-up evaluation was conducted in 1999-2000, with a response rate of 92.9%.

RESULTS

A total of 829 CHD events (fatal and nonfatal) were observed among the participants who were free of cardiovascular diseases (CVD) at baseline. Higher SBP was significantly associated with more risk of CHD in both nonsmokers and current smokers (all p < 0.0001 for linear trends). Comparing with never smoking, both low and high levels of cigarettes smoked per day (1-7, and >or=8 cigarettes per day) and pack-years (<10, and >or=10 pack-years) were associated with increased risk of CHD in those with normal and high SBP. The multivariate adjusted relative risks (RRs) of CHD were 2.54 (95% confidence interval [CI] 2.00-3.23), 1.28 (1.01-1.63), and 1.57 (1.33-1.86) for current smokers with high SBP, current smokers with normal SBP, and nonsmokers with high SBP, respectively, compared with nonsmokers with normal SBP. The present study identified a statistically significant additive interaction between these two factors on CHD.

CONCLUSIONS

Our study indicated that the combined effects of cigarette smoking and high SBP could be expected to have extra adverse effects on CHD in women, which highlights the importance of multifactorial interventions to decrease the risk of CHD, for example, quitting smoking and treatment of high blood pressure in Chinese women.

Authors+Show Affiliations

Department of Evidence Based Medicine, Cardiovascular Institute & FuWai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20201701

Citation

Sun, Dongling, et al. "Combined Effects of Smoking and Systolic Blood Pressure On Risk of Coronary Heart Disease: a Cohort Study in Chinese Women." Journal of Women's Health (2002), vol. 19, no. 4, 2010, pp. 713-8.
Sun D, Cao J, Liu X, et al. Combined effects of smoking and systolic blood pressure on risk of coronary heart disease: a cohort study in Chinese women. J Womens Health (Larchmt). 2010;19(4):713-8.
Sun, D., Cao, J., Liu, X., Yu, L., Yao, C., Li, J., ... Gu, D. (2010). Combined effects of smoking and systolic blood pressure on risk of coronary heart disease: a cohort study in Chinese women. Journal of Women's Health (2002), 19(4), pp. 713-8. doi:10.1089/jwh.2009.1486.
Sun D, et al. Combined Effects of Smoking and Systolic Blood Pressure On Risk of Coronary Heart Disease: a Cohort Study in Chinese Women. J Womens Health (Larchmt). 2010;19(4):713-8. PubMed PMID: 20201701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined effects of smoking and systolic blood pressure on risk of coronary heart disease: a cohort study in Chinese women. AU - Sun,Dongling, AU - Cao,Jie, AU - Liu,Xiaoqing, AU - Yu,Ling, AU - Yao,Chonghua, AU - Li,Jianxin, AU - Yu,Dahai, AU - Chen,Jing, AU - Chen,Jichun, AU - Wu,Xigui, AU - Huang,Jianfeng, AU - He,Jiang, AU - Gu,Dongfeng, PY - 2010/3/6/entrez PY - 2010/3/6/pubmed PY - 2012/4/17/medline SP - 713 EP - 8 JF - Journal of women's health (2002) JO - J Womens Health (Larchmt) VL - 19 IS - 4 N2 - OBJECTIVES: To quantify the combined effects of systolic blood pressure (SBP) and cigarette smoking on incident coronary heart disease (CHD) in women. METHODS: Overall, 86,338 women aged >or=40 years were enrolled in 1991. The follow-up evaluation was conducted in 1999-2000, with a response rate of 92.9%. RESULTS: A total of 829 CHD events (fatal and nonfatal) were observed among the participants who were free of cardiovascular diseases (CVD) at baseline. Higher SBP was significantly associated with more risk of CHD in both nonsmokers and current smokers (all p < 0.0001 for linear trends). Comparing with never smoking, both low and high levels of cigarettes smoked per day (1-7, and >or=8 cigarettes per day) and pack-years (<10, and >or=10 pack-years) were associated with increased risk of CHD in those with normal and high SBP. The multivariate adjusted relative risks (RRs) of CHD were 2.54 (95% confidence interval [CI] 2.00-3.23), 1.28 (1.01-1.63), and 1.57 (1.33-1.86) for current smokers with high SBP, current smokers with normal SBP, and nonsmokers with high SBP, respectively, compared with nonsmokers with normal SBP. The present study identified a statistically significant additive interaction between these two factors on CHD. CONCLUSIONS: Our study indicated that the combined effects of cigarette smoking and high SBP could be expected to have extra adverse effects on CHD in women, which highlights the importance of multifactorial interventions to decrease the risk of CHD, for example, quitting smoking and treatment of high blood pressure in Chinese women. SN - 1931-843X UR - https://www.unboundmedicine.com/medline/citation/20201701/Combined_effects_of_smoking_and_systolic_blood_pressure_on_risk_of_coronary_heart_disease:_a_cohort_study_in_Chinese_women_ L2 - https://www.liebertpub.com/doi/full/10.1089/jwh.2009.1486?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -