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Epidemiology, clinical manifestations, and recent advances in vaccination against human papillomavirus.
Postgrad Med. 2010 Mar; 122(2):121-9.PM

Abstract

In October 2009, the Advisory Committee on Immunization Practices (ACIP) approved a newly licensed vaccine, Cervarix, directed against human papillomavirus (HPV) to prevent cervical cancer. The ACIP also expanded its recommendations against HPV by giving permission to physicians to vaccinate males aged 9 to 26 years with the previously licensed vaccine, Gardasil, to prevent genital warts, in addition to its previous recommendation for females aged 9 to 26 years to prevent cervical cancer and genital warts. The marketing, expense, safety, and reactivity of Gardasil continue to be the subject of controversy. Of the >100 types of HPVs, approximately 40 are sexually transmitted, and HPV is the most common sexually transmitted disease. By age 50 years, 80% of women will have contracted a sexually transmitted HPV infection. While most individuals are clear of infection by 2 years, some types of HPV carry a high risk for progressing to cancer, and HPV is identified in >99% of patients with cervical cancer. Each year in the United States approximately 12,000 women develop cervical cancer and nearly 4000 die of it. Human papillomavirus is also associated with genital warts and other anogenital cancers. The United States has now licensed 2 vaccines against HPV, Gardasil and Cervarix. Gardasil has been shown to be safe and effective in preventing HPV infections by types 6, 11, 16, and 18; types 16 and 18 are associated with 2 high-risk types of cervical cancer and are associated with 70% of all cervical cancers. Types 6 and 11 are associated with 90% of anogenital warts. Cervarix has also been shown to be safe and effective in preventing HPV infections by types 16 and 18, but offers no known protection against anogenital warts.

Authors+Show Affiliations

Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905-0001, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20203463

Citation

Broomall, Eileen M., et al. "Epidemiology, Clinical Manifestations, and Recent Advances in Vaccination Against Human Papillomavirus." Postgraduate Medicine, vol. 122, no. 2, 2010, pp. 121-9.
Broomall EM, Reynolds SM, Jacobson RM. Epidemiology, clinical manifestations, and recent advances in vaccination against human papillomavirus. Postgrad Med. 2010;122(2):121-9.
Broomall, E. M., Reynolds, S. M., & Jacobson, R. M. (2010). Epidemiology, clinical manifestations, and recent advances in vaccination against human papillomavirus. Postgraduate Medicine, 122(2), 121-9. https://doi.org/10.3810/pgm.2010.03.2129
Broomall EM, Reynolds SM, Jacobson RM. Epidemiology, Clinical Manifestations, and Recent Advances in Vaccination Against Human Papillomavirus. Postgrad Med. 2010;122(2):121-9. PubMed PMID: 20203463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology, clinical manifestations, and recent advances in vaccination against human papillomavirus. AU - Broomall,Eileen M, AU - Reynolds,Sonya M, AU - Jacobson,Robert M, PY - 2010/3/6/entrez PY - 2010/3/6/pubmed PY - 2010/4/2/medline SP - 121 EP - 9 JF - Postgraduate medicine JO - Postgrad Med VL - 122 IS - 2 N2 - In October 2009, the Advisory Committee on Immunization Practices (ACIP) approved a newly licensed vaccine, Cervarix, directed against human papillomavirus (HPV) to prevent cervical cancer. The ACIP also expanded its recommendations against HPV by giving permission to physicians to vaccinate males aged 9 to 26 years with the previously licensed vaccine, Gardasil, to prevent genital warts, in addition to its previous recommendation for females aged 9 to 26 years to prevent cervical cancer and genital warts. The marketing, expense, safety, and reactivity of Gardasil continue to be the subject of controversy. Of the >100 types of HPVs, approximately 40 are sexually transmitted, and HPV is the most common sexually transmitted disease. By age 50 years, 80% of women will have contracted a sexually transmitted HPV infection. While most individuals are clear of infection by 2 years, some types of HPV carry a high risk for progressing to cancer, and HPV is identified in >99% of patients with cervical cancer. Each year in the United States approximately 12,000 women develop cervical cancer and nearly 4000 die of it. Human papillomavirus is also associated with genital warts and other anogenital cancers. The United States has now licensed 2 vaccines against HPV, Gardasil and Cervarix. Gardasil has been shown to be safe and effective in preventing HPV infections by types 6, 11, 16, and 18; types 16 and 18 are associated with 2 high-risk types of cervical cancer and are associated with 70% of all cervical cancers. Types 6 and 11 are associated with 90% of anogenital warts. Cervarix has also been shown to be safe and effective in preventing HPV infections by types 16 and 18, but offers no known protection against anogenital warts. SN - 1941-9260 UR - https://www.unboundmedicine.com/medline/citation/20203463/Epidemiology_clinical_manifestations_and_recent_advances_in_vaccination_against_human_papillomavirus_ L2 - https://www.tandfonline.com/doi/full/10.3810/pgm.2010.03.2129 DB - PRIME DP - Unbound Medicine ER -