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Clinical evaluation and treatment of chronic urticaria.
Postgrad Med. 2010 Mar; 122(2):148-56.PM

Abstract

Chronic urticaria is a common disease characterized by recurrent pruritic wheals with surrounding erythema for >6 weeks. It is associated with a significant health care burden and affects patient quality of life. The etiology of chronic urticaria is often difficult to elucidate; however, known etiologies include autoimmune urticaria, physical urticarias (eg, cold, cholinergic, and delayed pressure urticaria), and idiopathic urticaria. The etiology is unknown in many patients, leading to a diagnosis of chronic idiopathic urticaria. The diagnosis of chronic idiopathic urticaria can be challenging for the primary care physician because of the disease's chronic symptoms. Diagnosis requires a detailed patient history and comprehensive physical examination, with additional testing tailored to the patient's history. Effective treatments include antihistamines, leukotriene receptor antagonists in combination with antihistamines, and oral immunomodulatory drugs, including corticosteroids, cyclosporine, dapsone, hydroxychloroquine, and sulfasalazine. Newer experimental therapies include intravenous immunoglobulin and omalizumab. This article reviews the pathophysiology, diagnosis, and treatment of chronic urticaria.

Authors+Show Affiliations

Winthrop University Hospital, Mineola, NY 11501, USA. LFonacier@Winthrop.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

20203466

Citation

Fonacier, Luz, et al. "Clinical Evaluation and Treatment of Chronic Urticaria." Postgraduate Medicine, vol. 122, no. 2, 2010, pp. 148-56.
Fonacier L, Aquino M, Kim B. Clinical evaluation and treatment of chronic urticaria. Postgrad Med. 2010;122(2):148-56.
Fonacier, L., Aquino, M., & Kim, B. (2010). Clinical evaluation and treatment of chronic urticaria. Postgraduate Medicine, 122(2), 148-56. https://doi.org/10.3810/pgm.2010.03.2132
Fonacier L, Aquino M, Kim B. Clinical Evaluation and Treatment of Chronic Urticaria. Postgrad Med. 2010;122(2):148-56. PubMed PMID: 20203466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical evaluation and treatment of chronic urticaria. AU - Fonacier,Luz, AU - Aquino,Marcella, AU - Kim,Bora, PY - 2010/3/6/entrez PY - 2010/3/6/pubmed PY - 2010/4/2/medline SP - 148 EP - 56 JF - Postgraduate medicine JO - Postgrad Med VL - 122 IS - 2 N2 - Chronic urticaria is a common disease characterized by recurrent pruritic wheals with surrounding erythema for >6 weeks. It is associated with a significant health care burden and affects patient quality of life. The etiology of chronic urticaria is often difficult to elucidate; however, known etiologies include autoimmune urticaria, physical urticarias (eg, cold, cholinergic, and delayed pressure urticaria), and idiopathic urticaria. The etiology is unknown in many patients, leading to a diagnosis of chronic idiopathic urticaria. The diagnosis of chronic idiopathic urticaria can be challenging for the primary care physician because of the disease's chronic symptoms. Diagnosis requires a detailed patient history and comprehensive physical examination, with additional testing tailored to the patient's history. Effective treatments include antihistamines, leukotriene receptor antagonists in combination with antihistamines, and oral immunomodulatory drugs, including corticosteroids, cyclosporine, dapsone, hydroxychloroquine, and sulfasalazine. Newer experimental therapies include intravenous immunoglobulin and omalizumab. This article reviews the pathophysiology, diagnosis, and treatment of chronic urticaria. SN - 1941-9260 UR - https://www.unboundmedicine.com/medline/citation/20203466/Clinical_evaluation_and_treatment_of_chronic_urticaria_ L2 - https://www.tandfonline.com/doi/full/10.3810/pgm.2010.03.2132 DB - PRIME DP - Unbound Medicine ER -