TY - JOUR T1 - Novel thiourea-amine bifunctional catalysts for asymmetric conjugate addition of ketones/aldehydes to nitroalkenes: rational structural combination for high catalytic efficiency. AU - Chen,Jia-Rong, AU - Cao,Yi-Ju, AU - Zou,You-Quan, AU - Tan,Fen, AU - Fu,Liang, AU - Zhu,Xiao-Yu, AU - Xiao,Wen-Jing, Y1 - 2010/01/21/ PY - 2010/3/6/entrez PY - 2010/3/6/pubmed PY - 2010/6/10/medline SP - 1275 EP - 9 JF - Organic & biomolecular chemistry JO - Org Biomol Chem VL - 8 IS - 6 N2 - A series of thiourea-amine bifunctional catalysts have been developed by a rational combination of prolines with cinchona alkaloids, which are connected by a thiourea motif. The catalyst 3a, prepared from L-proline and cinchonidine, was found to be a highly efficient catalyst for the conjugate addition of ketones/aldehydes to a wide range of nitroalkenes (up to 98/2 dr and 96% ee). The privileged cinchonidine backbone and the thiourea motif are essential to the reaction activity and enantioselectivity. SN - 1477-0539 UR - https://www.unboundmedicine.com/medline/citation/20204193/Novel_thiourea_amine_bifunctional_catalysts_for_asymmetric_conjugate_addition_of_ketones/aldehydes_to_nitroalkenes:_rational_structural_combination_for_high_catalytic_efficiency_ L2 - https://doi.org/10.1039/b925962g DB - PRIME DP - Unbound Medicine ER -