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Dynamic planar solid phase microextraction-ion mobility spectrometry for rapid field air sampling and analysis of illicit drugs and explosives.
Anal Chem. 2010 Apr 01; 82(7):2826-35.AC

Abstract

A preconcentration device that targets the volatile chemical signatures associated with illicit drugs and explosives (high and low) has been designed to fit in the inlet of an ion mobility spectrometer (IMS). This is the first reporting of a fast and sensitive method for dynamic sampling of large volumes of air using planar solid phase microextraction (PSPME) incorporating a high surface area for absorption of analytes onto a sol-gel polydimethylsiloxane (PDMS) coating for direct thermal desorption into an IMS. This device affords high extraction efficiencies due to strong retention properties at ambient temperature, resulting in the detection of analyte concentrations in the parts per trillion range when as low as 3.5 L of air are sampled over the course of 10 s (absolute mass detection of less than a nanogram). Dynamic PSPME was used to sample the headspace over the following: 3,4-methylenedioxymethamphetamine (MDMA) tablets resulting in the detection of 12-40 ng of piperonal, high explosives (Pentolite) resulting in the detection of 0.6 ng of 2,4,6-trinitrotoluene (TNT), and low explosives (several smokeless powders) resulting in the detection of 26-35 ng of 2,4-dinitrotoluene (2,4-DNT) and 11-74 ng of diphenylamine (DPA).

Authors+Show Affiliations

Department of Chemistry and Biochemistry and International Forensic Research Institute, Florida International University, Miami, FL 33199, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

20205382

Citation

Guerra-Diaz, Patricia, et al. "Dynamic Planar Solid Phase Microextraction-ion Mobility Spectrometry for Rapid Field Air Sampling and Analysis of Illicit Drugs and Explosives." Analytical Chemistry, vol. 82, no. 7, 2010, pp. 2826-35.
Guerra-Diaz P, Gura S, Almirall JR. Dynamic planar solid phase microextraction-ion mobility spectrometry for rapid field air sampling and analysis of illicit drugs and explosives. Anal Chem. 2010;82(7):2826-35.
Guerra-Diaz, P., Gura, S., & Almirall, J. R. (2010). Dynamic planar solid phase microextraction-ion mobility spectrometry for rapid field air sampling and analysis of illicit drugs and explosives. Analytical Chemistry, 82(7), 2826-35. https://doi.org/10.1021/ac902785y
Guerra-Diaz P, Gura S, Almirall JR. Dynamic Planar Solid Phase Microextraction-ion Mobility Spectrometry for Rapid Field Air Sampling and Analysis of Illicit Drugs and Explosives. Anal Chem. 2010 Apr 1;82(7):2826-35. PubMed PMID: 20205382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dynamic planar solid phase microextraction-ion mobility spectrometry for rapid field air sampling and analysis of illicit drugs and explosives. AU - Guerra-Diaz,Patricia, AU - Gura,Sigalit, AU - Almirall,José R, PY - 2010/3/9/entrez PY - 2010/3/9/pubmed PY - 2010/6/24/medline SP - 2826 EP - 35 JF - Analytical chemistry JO - Anal. Chem. VL - 82 IS - 7 N2 - A preconcentration device that targets the volatile chemical signatures associated with illicit drugs and explosives (high and low) has been designed to fit in the inlet of an ion mobility spectrometer (IMS). This is the first reporting of a fast and sensitive method for dynamic sampling of large volumes of air using planar solid phase microextraction (PSPME) incorporating a high surface area for absorption of analytes onto a sol-gel polydimethylsiloxane (PDMS) coating for direct thermal desorption into an IMS. This device affords high extraction efficiencies due to strong retention properties at ambient temperature, resulting in the detection of analyte concentrations in the parts per trillion range when as low as 3.5 L of air are sampled over the course of 10 s (absolute mass detection of less than a nanogram). Dynamic PSPME was used to sample the headspace over the following: 3,4-methylenedioxymethamphetamine (MDMA) tablets resulting in the detection of 12-40 ng of piperonal, high explosives (Pentolite) resulting in the detection of 0.6 ng of 2,4,6-trinitrotoluene (TNT), and low explosives (several smokeless powders) resulting in the detection of 26-35 ng of 2,4-dinitrotoluene (2,4-DNT) and 11-74 ng of diphenylamine (DPA). SN - 1520-6882 UR - https://www.unboundmedicine.com/medline/citation/20205382/Dynamic_planar_solid_phase_microextraction_ion_mobility_spectrometry_for_rapid_field_air_sampling_and_analysis_of_illicit_drugs_and_explosives_ L2 - https://dx.doi.org/10.1021/ac902785y DB - PRIME DP - Unbound Medicine ER -