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Effect of water-matrix composition on Trimethoprim solar photodegradation kinetics and pathways.
Water Res. 2010 May; 44(9):2735-44.WR

Abstract

Direct photolysis and solar TiO(2) photocatalysis of Trimethoprim (TMP) in different water matrices (demineralised and simulated seawater) have been studied. Direct photolysis yielded a similar, slow TMP degradation rate in both water matrices, and the formation of very stable photo-transformation products. Dissolved organic carbon decreased slightly after prolonged irradiation. The main intermediate identified was a ketone derivative (trimethoxybenzoylpyrimidine), which was proved to be a photosensitizer of TMP degradation. During TiO(2) photocatalysis, TMP was completely eliminated in both water matrices at a similar rate, however, the mineralization rate was appreciably reduced in seawater, which can be explained by the presence of inorganic species acting as hydroxyl radical scavengers, and directly affecting photocatalytic efficiency. Identification of intermediates showed differences between the two processes but hydroxylation, demethylation and cleavage of the original drug molecule were observed in both.

Authors+Show Affiliations

Pesticide Residue Research Group, University of Almería, Carretera Sacramento s/n, La Cañada, Almería, Spain. aaguera@ual.esNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20206373

Citation

Sirtori, Carla, et al. "Effect of Water-matrix Composition On Trimethoprim Solar Photodegradation Kinetics and Pathways." Water Research, vol. 44, no. 9, 2010, pp. 2735-44.
Sirtori C, Agüera A, Gernjak W, et al. Effect of water-matrix composition on Trimethoprim solar photodegradation kinetics and pathways. Water Res. 2010;44(9):2735-44.
Sirtori, C., Agüera, A., Gernjak, W., & Malato, S. (2010). Effect of water-matrix composition on Trimethoprim solar photodegradation kinetics and pathways. Water Research, 44(9), 2735-44. https://doi.org/10.1016/j.watres.2010.02.006
Sirtori C, et al. Effect of Water-matrix Composition On Trimethoprim Solar Photodegradation Kinetics and Pathways. Water Res. 2010;44(9):2735-44. PubMed PMID: 20206373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of water-matrix composition on Trimethoprim solar photodegradation kinetics and pathways. AU - Sirtori,Carla, AU - Agüera,Ana, AU - Gernjak,Wolfgang, AU - Malato,Sixto, Y1 - 2010/02/16/ PY - 2009/11/30/received PY - 2010/02/03/revised PY - 2010/02/03/accepted PY - 2010/3/9/entrez PY - 2010/3/9/pubmed PY - 2010/8/14/medline SP - 2735 EP - 44 JF - Water research JO - Water Res VL - 44 IS - 9 N2 - Direct photolysis and solar TiO(2) photocatalysis of Trimethoprim (TMP) in different water matrices (demineralised and simulated seawater) have been studied. Direct photolysis yielded a similar, slow TMP degradation rate in both water matrices, and the formation of very stable photo-transformation products. Dissolved organic carbon decreased slightly after prolonged irradiation. The main intermediate identified was a ketone derivative (trimethoxybenzoylpyrimidine), which was proved to be a photosensitizer of TMP degradation. During TiO(2) photocatalysis, TMP was completely eliminated in both water matrices at a similar rate, however, the mineralization rate was appreciably reduced in seawater, which can be explained by the presence of inorganic species acting as hydroxyl radical scavengers, and directly affecting photocatalytic efficiency. Identification of intermediates showed differences between the two processes but hydroxylation, demethylation and cleavage of the original drug molecule were observed in both. SN - 1879-2448 UR - https://www.unboundmedicine.com/medline/citation/20206373/Effect_of_water_matrix_composition_on_Trimethoprim_solar_photodegradation_kinetics_and_pathways_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0043-1354(10)00095-3 DB - PRIME DP - Unbound Medicine ER -