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Ocular risk factors for choroidal neovascularization in pathologic myopia.
Invest Ophthalmol Vis Sci 2010; 51(7):3721-5IO

Abstract

PURPOSE. To identify the risk factors for development of myopic choroidal neovascularization (mCNV), a major cause of visual impairment. METHODS. Enrolled in the study were 23 consecutive patients with bilateral high myopia (axial length, > or =26.5 mm or refractive error, < or =8 D) and unilateral newly developed mCNV who presented to the Myopia Clinic, Osaka University Hospital. Spectral-domain optical coherence tomography (SD-OCT) showed that the fellow eyes had a normal macula. The parameters in the affected and fellow eyes were compared between the individual patients, including best-corrected visual acuity (BCVA), intraocular pressure (IOP), refractive error, axial length, choroidal thickness (CT) (subfoveal, 1.5 mm superiorly and inferiorly), posterior staphyloma height 3 mm from the fovea, length of retinal pigment epithelium (RPE) curvature within 6 mm measured on SD-OCT images, and choroidal degeneration and lacquer crack formation, graded according to a published

METHOD

RESULTS. The IOP, axial length, refractive error, and chorioretinal degeneration did not differ significantly. Affected eyes had a significantly higher lacquer crack grade (P < 0.05). The superior CT was not significantly different; the subfoveal and inferior CTs were significantly lower in the affected eyes (P < 0.05 and P < 0.001, respectively). The absolute value of the nasal posterior staphyloma height from the fovea was significantly greater in the affected eyes (P < 0.05), and the affected eyes had a significantly (P < 0.05) longer RPE curvature. CONCLUSIONS. Choroidal thinning resulting from increased RPE/choroid curvature is a risk factor for unilateral mCNV.

Authors+Show Affiliations

Departments of Ophthalmology, Osaka University Medical School, Osaka, Japan. ikuno@ophthal.med.osaka-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20207975

Citation

Ikuno, Yasushi, et al. "Ocular Risk Factors for Choroidal Neovascularization in Pathologic Myopia." Investigative Ophthalmology & Visual Science, vol. 51, no. 7, 2010, pp. 3721-5.
Ikuno Y, Jo Y, Hamasaki T, et al. Ocular risk factors for choroidal neovascularization in pathologic myopia. Invest Ophthalmol Vis Sci. 2010;51(7):3721-5.
Ikuno, Y., Jo, Y., Hamasaki, T., & Tano, Y. (2010). Ocular risk factors for choroidal neovascularization in pathologic myopia. Investigative Ophthalmology & Visual Science, 51(7), pp. 3721-5. doi:10.1167/iovs.09-3493.
Ikuno Y, et al. Ocular Risk Factors for Choroidal Neovascularization in Pathologic Myopia. Invest Ophthalmol Vis Sci. 2010;51(7):3721-5. PubMed PMID: 20207975.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ocular risk factors for choroidal neovascularization in pathologic myopia. AU - Ikuno,Yasushi, AU - Jo,Yukari, AU - Hamasaki,Toshimitsu, AU - Tano,Yasuo, Y1 - 2010/03/05/ PY - 2010/3/9/entrez PY - 2010/3/9/pubmed PY - 2010/8/3/medline SP - 3721 EP - 5 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 51 IS - 7 N2 - UNLABELLED: PURPOSE. To identify the risk factors for development of myopic choroidal neovascularization (mCNV), a major cause of visual impairment. METHODS. Enrolled in the study were 23 consecutive patients with bilateral high myopia (axial length, > or =26.5 mm or refractive error, < or =8 D) and unilateral newly developed mCNV who presented to the Myopia Clinic, Osaka University Hospital. Spectral-domain optical coherence tomography (SD-OCT) showed that the fellow eyes had a normal macula. The parameters in the affected and fellow eyes were compared between the individual patients, including best-corrected visual acuity (BCVA), intraocular pressure (IOP), refractive error, axial length, choroidal thickness (CT) (subfoveal, 1.5 mm superiorly and inferiorly), posterior staphyloma height 3 mm from the fovea, length of retinal pigment epithelium (RPE) curvature within 6 mm measured on SD-OCT images, and choroidal degeneration and lacquer crack formation, graded according to a published METHOD: RESULTS. The IOP, axial length, refractive error, and chorioretinal degeneration did not differ significantly. Affected eyes had a significantly higher lacquer crack grade (P < 0.05). The superior CT was not significantly different; the subfoveal and inferior CTs were significantly lower in the affected eyes (P < 0.05 and P < 0.001, respectively). The absolute value of the nasal posterior staphyloma height from the fovea was significantly greater in the affected eyes (P < 0.05), and the affected eyes had a significantly (P < 0.05) longer RPE curvature. CONCLUSIONS. Choroidal thinning resulting from increased RPE/choroid curvature is a risk factor for unilateral mCNV. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/20207975/Ocular_risk_factors_for_choroidal_neovascularization_in_pathologic_myopia_ L2 - http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.09-3493 DB - PRIME DP - Unbound Medicine ER -