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Microwave assisted synthesis of some novel 2-pyrazoline derivatives as possible antimicrobial agents.
Acta Pol Pharm. 2010 Jan-Feb; 67(1):55-61.AP

Abstract

Some new [3-(4-phenyl)-5-phenyl-4,5-dihydropyrazol-1-yl](pyridine-4-yl)methanones and 3-substituted phenyl-5-substituted phenyl-4,5-dihydro-pyrazole-1-carbothioamides have been synthesized employing microwave techniques and evaluated for antimicrobial activity. Substituted acetophenones (1) were reacted with appropriately substituted benzaldehydes (2) in the presence of ethanol to furnish substituted chalcones (3a-f). These chalcones were further treated with isonicotinic acid hydrazide (INH) to afford substituted [3-(4-phenyl)-5-phenyl-4,5-dihydropyrazol-1-yl](pyridine-4-yl)methanones (4a-f). Reaction of these chalcones with thiosemicarbazide yielded substituted 3,5-diphenyl-4,5-dihydro-1H-pyrazole-1-carbothioamides (5a-f). The structures of newly synthesized compounds (4a-f) and (5a-f) have been confirmed by suitable spectroscopic techniques such as IR and 1H NMR. All the compounds were screened for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and for antifungal activity against Candida albicans and Aspergillus niger The compounds exhibited moderate antibacterial and good antifungal activities. Compound 4b and 4d showed significant antifungal activity against A. niger and C. albicans, respectively.

Authors+Show Affiliations

Department of Pharmaceutical Chemistry, S.D. College of Pharmacy, Barnala-148 101, India. rchawlapharma@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20210079

Citation

Chawla, Rakesh, et al. "Microwave Assisted Synthesis of some Novel 2-pyrazoline Derivatives as Possible Antimicrobial Agents." Acta Poloniae Pharmaceutica, vol. 67, no. 1, 2010, pp. 55-61.
Chawla R, Sahoo U, Arora A, et al. Microwave assisted synthesis of some novel 2-pyrazoline derivatives as possible antimicrobial agents. Acta Pol Pharm. 2010;67(1):55-61.
Chawla, R., Sahoo, U., Arora, A., Sharma, P. C., & Radhakrishnan, V. (2010). Microwave assisted synthesis of some novel 2-pyrazoline derivatives as possible antimicrobial agents. Acta Poloniae Pharmaceutica, 67(1), 55-61.
Chawla R, et al. Microwave Assisted Synthesis of some Novel 2-pyrazoline Derivatives as Possible Antimicrobial Agents. Acta Pol Pharm. 2010 Jan-Feb;67(1):55-61. PubMed PMID: 20210079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microwave assisted synthesis of some novel 2-pyrazoline derivatives as possible antimicrobial agents. AU - Chawla,Rakesh, AU - Sahoo,Ujjwal, AU - Arora,Anshu, AU - Sharma,Prabodh Chander, AU - Radhakrishnan,Vijayaraj, PY - 2010/3/10/entrez PY - 2010/3/10/pubmed PY - 2010/4/2/medline SP - 55 EP - 61 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 67 IS - 1 N2 - Some new [3-(4-phenyl)-5-phenyl-4,5-dihydropyrazol-1-yl](pyridine-4-yl)methanones and 3-substituted phenyl-5-substituted phenyl-4,5-dihydro-pyrazole-1-carbothioamides have been synthesized employing microwave techniques and evaluated for antimicrobial activity. Substituted acetophenones (1) were reacted with appropriately substituted benzaldehydes (2) in the presence of ethanol to furnish substituted chalcones (3a-f). These chalcones were further treated with isonicotinic acid hydrazide (INH) to afford substituted [3-(4-phenyl)-5-phenyl-4,5-dihydropyrazol-1-yl](pyridine-4-yl)methanones (4a-f). Reaction of these chalcones with thiosemicarbazide yielded substituted 3,5-diphenyl-4,5-dihydro-1H-pyrazole-1-carbothioamides (5a-f). The structures of newly synthesized compounds (4a-f) and (5a-f) have been confirmed by suitable spectroscopic techniques such as IR and 1H NMR. All the compounds were screened for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and for antifungal activity against Candida albicans and Aspergillus niger The compounds exhibited moderate antibacterial and good antifungal activities. Compound 4b and 4d showed significant antifungal activity against A. niger and C. albicans, respectively. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/20210079/Microwave_assisted_synthesis_of_some_novel_2_pyrazoline_derivatives_as_possible_antimicrobial_agents_ L2 - http://www.ptfarm.pl/pub/File/Acta_Poloniae/2010/1/055.pdf DB - PRIME DP - Unbound Medicine ER -