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Modulation of age-related NF-kappaB activation by dietary zingerone via MAPK pathway.
Exp Gerontol. 2010 Jun; 45(6):419-26.EG

Abstract

Zingerone, a major component found in ginger root, has been known as anti-mutagenic and anti-carcinogenic activities that are often associated with its anti-oxidative and anti-inflammatory activities. In recent studies, we examined molecular mechanism of zingerone treatment on pro-inflammatory NF-kappaB activation via the redox-related NIK/IKK and MAPK pathways. Action mechanism of zingerone on NF-kappaB signaling was investigated in aged rat kidney and endothelial cells. The results showed that zingerone had not only the antioxidant effect by constitutive suppression of ROS, but also anti-inflammatory effects by suppression of nuclear factor (NF)-kappaB activation in aged rat. In addition, zingerone treatment suppressed gene activation of pro-inflammatory enzymes, COX-2 and iNOS, which were upregulated with aging through NF-kappaB activation and IKK/MAPK signaling pathway. These experiments strongly indicate that zingerone treatment exerts a beneficial efficacy by suppressing both oxidative stress and age-related inflammation through the modulation of several key pro-inflammatory genes and transcription factors. Thus, the significance of our findings is that the zingerone treatment may provide some preventive measure against chronic inflammatory conditions that underlie many age-related inflammatory diseases, such as metabolic syndrome, cardiovascular disease, dementia, arthritis, diabetes, osteoprosis, and cancers.

Authors+Show Affiliations

Department of Pharmacy, Pusan National University, Busan, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20211236

Citation

Kim, Mi Kyung, et al. "Modulation of Age-related NF-kappaB Activation By Dietary Zingerone Via MAPK Pathway." Experimental Gerontology, vol. 45, no. 6, 2010, pp. 419-26.
Kim MK, Chung SW, Kim DH, et al. Modulation of age-related NF-kappaB activation by dietary zingerone via MAPK pathway. Exp Gerontol. 2010;45(6):419-26.
Kim, M. K., Chung, S. W., Kim, D. H., Kim, J. M., Lee, E. K., Kim, J. Y., Ha, Y. M., Kim, Y. H., No, J. K., Chung, H. S., Park, K. Y., Rhee, S. H., Choi, J. S., Yu, B. P., Yokozawa, T., Kim, Y. J., & Chung, H. Y. (2010). Modulation of age-related NF-kappaB activation by dietary zingerone via MAPK pathway. Experimental Gerontology, 45(6), 419-26. https://doi.org/10.1016/j.exger.2010.03.005
Kim MK, et al. Modulation of Age-related NF-kappaB Activation By Dietary Zingerone Via MAPK Pathway. Exp Gerontol. 2010;45(6):419-26. PubMed PMID: 20211236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of age-related NF-kappaB activation by dietary zingerone via MAPK pathway. AU - Kim,Mi Kyung, AU - Chung,Sang Woon, AU - Kim,Dae Hyun, AU - Kim,Ji Min, AU - Lee,Eun Kyeong, AU - Kim,Ji Young, AU - Ha,Young Mi, AU - Kim,Yun Hee, AU - No,Jae-Kyung, AU - Chung,Hye Sun, AU - Park,Kun-Young, AU - Rhee,Sook Hee, AU - Choi,Jae Sue, AU - Yu,Byung Pal, AU - Yokozawa,Takako, AU - Kim,Young Jin, AU - Chung,Hae Young, Y1 - 2010/03/06/ PY - 2009/07/27/received PY - 2010/02/11/revised PY - 2010/03/02/accepted PY - 2010/3/10/entrez PY - 2010/3/10/pubmed PY - 2010/8/5/medline SP - 419 EP - 26 JF - Experimental gerontology JO - Exp Gerontol VL - 45 IS - 6 N2 - Zingerone, a major component found in ginger root, has been known as anti-mutagenic and anti-carcinogenic activities that are often associated with its anti-oxidative and anti-inflammatory activities. In recent studies, we examined molecular mechanism of zingerone treatment on pro-inflammatory NF-kappaB activation via the redox-related NIK/IKK and MAPK pathways. Action mechanism of zingerone on NF-kappaB signaling was investigated in aged rat kidney and endothelial cells. The results showed that zingerone had not only the antioxidant effect by constitutive suppression of ROS, but also anti-inflammatory effects by suppression of nuclear factor (NF)-kappaB activation in aged rat. In addition, zingerone treatment suppressed gene activation of pro-inflammatory enzymes, COX-2 and iNOS, which were upregulated with aging through NF-kappaB activation and IKK/MAPK signaling pathway. These experiments strongly indicate that zingerone treatment exerts a beneficial efficacy by suppressing both oxidative stress and age-related inflammation through the modulation of several key pro-inflammatory genes and transcription factors. Thus, the significance of our findings is that the zingerone treatment may provide some preventive measure against chronic inflammatory conditions that underlie many age-related inflammatory diseases, such as metabolic syndrome, cardiovascular disease, dementia, arthritis, diabetes, osteoprosis, and cancers. SN - 1873-6815 UR - https://www.unboundmedicine.com/medline/citation/20211236/Modulation_of_age_related_NF_kappaB_activation_by_dietary_zingerone_via_MAPK_pathway_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531-5565(10)00113-0 DB - PRIME DP - Unbound Medicine ER -