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Outcomes in diabetic versus nondiabetic patients who present with acute myocardial infarction and are treated with drug-eluting stents.
Am J Cardiol. 2010 Mar 15; 105(6):819-25.AJ

Abstract

Patients with diabetes mellitus (DM) are at a greater risk of mortality and cardiovascular events after percutaneous coronary intervention than those without DM. We aimed to determine whether differences exist in the long-term mortality of patients with versus without DM who present with acute myocardial infarction and receive drug-eluting stents. Data were collected on 161 patients with and 395 without DM referred for primary percutaneous coronary intervention for acute myocardial infarction and treated with drug-eluting stents. The patients with cardiac arrest or cardiogenic shock were excluded. The 1-year major cardiac event (MACE) rates, defined as death, Q-wave myocardial infarction, or target lesion revascularization, were compared between the 2 groups. The patients with DM were sicker at baseline. The MACE rates at 1 year were significantly increased in those with DM compared to those without DM. This was primarily driven by all-cause mortality. No differences in Q-wave myocardial infarction, target lesion revascularization, stent thrombosis, type of drug-eluting stents used, or procedure-related renal failure were seen. No differences were found in death or MACE rates at 1 year after adjusting for age, gender, race, systemic hypertension, peripheral artery disease, and a history of chronic renal failure between the 2 groups (weighted log-rank statistic, p = 0.37 and p = 0.37, respectively). In patients presenting with acute myocardial infarction, those with DM were sicker than those without DM. In conclusion, after correction for co-morbid conditions, no difference was seen in the 1-year MACE or death rates between those with and without DM who presented with acute myocardial infarction and were treated with drug-eluting stents.

Authors+Show Affiliations

Department of Medicine, Division of Cardiology, Washington Hospital Center, Washington, District of Columbia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20211325

Citation

Syed, Asmir I., et al. "Outcomes in Diabetic Versus Nondiabetic Patients Who Present With Acute Myocardial Infarction and Are Treated With Drug-eluting Stents." The American Journal of Cardiology, vol. 105, no. 6, 2010, pp. 819-25.
Syed AI, Ben-Dor I, Li Y, et al. Outcomes in diabetic versus nondiabetic patients who present with acute myocardial infarction and are treated with drug-eluting stents. Am J Cardiol. 2010;105(6):819-25.
Syed, A. I., Ben-Dor, I., Li, Y., Collins, S. D., Gonzalez, M. A., Gaglia, M. A., Maluenda, G., Delhaye, C., Wakabayashi, K., Bonello, L., De Labriolle, A., Belle, L., Torguson, R., Xue, Z., Kaneshige, K., Bernardo, N., Satler, L. F., Kent, K. M., Suddath, W. O., ... Waksman, R. (2010). Outcomes in diabetic versus nondiabetic patients who present with acute myocardial infarction and are treated with drug-eluting stents. The American Journal of Cardiology, 105(6), 819-25. https://doi.org/10.1016/j.amjcard.2009.11.010
Syed AI, et al. Outcomes in Diabetic Versus Nondiabetic Patients Who Present With Acute Myocardial Infarction and Are Treated With Drug-eluting Stents. Am J Cardiol. 2010 Mar 15;105(6):819-25. PubMed PMID: 20211325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outcomes in diabetic versus nondiabetic patients who present with acute myocardial infarction and are treated with drug-eluting stents. AU - Syed,Asmir I, AU - Ben-Dor,Itsik, AU - Li,Yanlin, AU - Collins,Sara D, AU - Gonzalez,Manuel A, AU - Gaglia,Michael A, AU - Maluenda,Gabriel, AU - Delhaye,Cedric, AU - Wakabayashi,Kohei, AU - Bonello,Laurant, AU - De Labriolle,Axel, AU - Belle,Loic, AU - Torguson,Rebecca, AU - Xue,Zhenyi, AU - Kaneshige,Kimberly, AU - Bernardo,Nelson, AU - Satler,Lowell F, AU - Kent,Kenneth M, AU - Suddath,William O, AU - Pichard,Augusto D, AU - Lindsay,Joseph, AU - Waksman,Ron, PY - 2009/09/21/received PY - 2009/11/08/revised PY - 2009/11/08/accepted PY - 2010/3/10/entrez PY - 2010/3/10/pubmed PY - 2010/3/30/medline SP - 819 EP - 25 JF - The American journal of cardiology JO - Am J Cardiol VL - 105 IS - 6 N2 - Patients with diabetes mellitus (DM) are at a greater risk of mortality and cardiovascular events after percutaneous coronary intervention than those without DM. We aimed to determine whether differences exist in the long-term mortality of patients with versus without DM who present with acute myocardial infarction and receive drug-eluting stents. Data were collected on 161 patients with and 395 without DM referred for primary percutaneous coronary intervention for acute myocardial infarction and treated with drug-eluting stents. The patients with cardiac arrest or cardiogenic shock were excluded. The 1-year major cardiac event (MACE) rates, defined as death, Q-wave myocardial infarction, or target lesion revascularization, were compared between the 2 groups. The patients with DM were sicker at baseline. The MACE rates at 1 year were significantly increased in those with DM compared to those without DM. This was primarily driven by all-cause mortality. No differences in Q-wave myocardial infarction, target lesion revascularization, stent thrombosis, type of drug-eluting stents used, or procedure-related renal failure were seen. No differences were found in death or MACE rates at 1 year after adjusting for age, gender, race, systemic hypertension, peripheral artery disease, and a history of chronic renal failure between the 2 groups (weighted log-rank statistic, p = 0.37 and p = 0.37, respectively). In patients presenting with acute myocardial infarction, those with DM were sicker than those without DM. In conclusion, after correction for co-morbid conditions, no difference was seen in the 1-year MACE or death rates between those with and without DM who presented with acute myocardial infarction and were treated with drug-eluting stents. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/20211325/Outcomes_in_diabetic_versus_nondiabetic_patients_who_present_with_acute_myocardial_infarction_and_are_treated_with_drug_eluting_stents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(09)02683-6 DB - PRIME DP - Unbound Medicine ER -