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Coagulation factor XIII-A Val34Leu polymorphism and the risk of coronary artery disease and myocardial infarction in a Chinese Han population.
Clin Appl Thromb Hemost. 2011 Apr; 17(2):208-13.CA

Abstract

There are controversial data regarding the impact of coagulation factor XIII A subunit (FXIII-A) Val34Leu polymorphism in the pathogeneric of coronary artery disease (CAD) and myocardial infarction (MI). Assuming this genetic factor is associated with the thrombotic process, we explored the role of FXIII-A Val34Leu in CAD and MI in a Chinese Han population. We recruited 195 consecutive patients with CAD confirmed by coronary angiography as well as a group of 203 controls. Factor XIII A Val34Leu polymorphism was determined through polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis. We did not find the Leu/Leu genotype in patients with CAD or controls. No significant difference in Val34Leu gene polymorphism distribution was found between patients with CAD and the controls (P = .923). Subgroup analysis according to the history of MI showed the heterozygote Val/Leu genotype was associated with a significantly decreased risk of MI (P = .005; adjusted odds ratio [OR] = 1.75; 95% confidence interval [CI] = 1.28-2.25). Furthermore, our study displayed that the frequency of the Leu34 allele in a Chinese Han population was lower than that in Caucasian populations (2.5 vs 20.4%-28.3%). Our preliminary data indicate that the FXIII-A Leu34 allele may contribute to a protective effect against the development of MI. There is a low prevalence of the Leu34 allele in Han Chinese compared to Caucasians.

Authors+Show Affiliations

Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20211923

Citation

Guodong Jin, , et al. "Coagulation Factor XIII-A Val34Leu Polymorphism and the Risk of Coronary Artery Disease and Myocardial Infarction in a Chinese Han Population." Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, vol. 17, no. 2, 2011, pp. 208-13.
Guodong Jin , Beili Feng , Peng Chen , et al. Coagulation factor XIII-A Val34Leu polymorphism and the risk of coronary artery disease and myocardial infarction in a Chinese Han population. Clin Appl Thromb Hemost. 2011;17(2):208-13.
Guodong Jin, ., Beili Feng, ., Peng Chen, ., Oushan Tang, ., Jian Wang, ., Ji Ma, ., Yuping Shi, ., & Geng Xu, . (2011). Coagulation factor XIII-A Val34Leu polymorphism and the risk of coronary artery disease and myocardial infarction in a Chinese Han population. Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 17(2), 208-13. https://doi.org/10.1177/1076029609355152
Guodong Jin , et al. Coagulation Factor XIII-A Val34Leu Polymorphism and the Risk of Coronary Artery Disease and Myocardial Infarction in a Chinese Han Population. Clin Appl Thromb Hemost. 2011;17(2):208-13. PubMed PMID: 20211923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coagulation factor XIII-A Val34Leu polymorphism and the risk of coronary artery disease and myocardial infarction in a Chinese Han population. AU - Guodong Jin,, AU - Beili Feng,, AU - Peng Chen,, AU - Oushan Tang,, AU - Jian Wang,, AU - Ji Ma,, AU - Yuping Shi,, AU - Geng Xu,, Y1 - 2010/03/08/ PY - 2010/3/10/entrez PY - 2010/3/10/pubmed PY - 2011/7/1/medline SP - 208 EP - 13 JF - Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis JO - Clin Appl Thromb Hemost VL - 17 IS - 2 N2 - There are controversial data regarding the impact of coagulation factor XIII A subunit (FXIII-A) Val34Leu polymorphism in the pathogeneric of coronary artery disease (CAD) and myocardial infarction (MI). Assuming this genetic factor is associated with the thrombotic process, we explored the role of FXIII-A Val34Leu in CAD and MI in a Chinese Han population. We recruited 195 consecutive patients with CAD confirmed by coronary angiography as well as a group of 203 controls. Factor XIII A Val34Leu polymorphism was determined through polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis. We did not find the Leu/Leu genotype in patients with CAD or controls. No significant difference in Val34Leu gene polymorphism distribution was found between patients with CAD and the controls (P = .923). Subgroup analysis according to the history of MI showed the heterozygote Val/Leu genotype was associated with a significantly decreased risk of MI (P = .005; adjusted odds ratio [OR] = 1.75; 95% confidence interval [CI] = 1.28-2.25). Furthermore, our study displayed that the frequency of the Leu34 allele in a Chinese Han population was lower than that in Caucasian populations (2.5 vs 20.4%-28.3%). Our preliminary data indicate that the FXIII-A Leu34 allele may contribute to a protective effect against the development of MI. There is a low prevalence of the Leu34 allele in Han Chinese compared to Caucasians. SN - 1938-2723 UR - https://www.unboundmedicine.com/medline/citation/20211923/Coagulation_factor_XIII_A_Val34Leu_polymorphism_and_the_risk_of_coronary_artery_disease_and_myocardial_infarction_in_a_Chinese_Han_population_ L2 - https://journals.sagepub.com/doi/10.1177/1076029609355152?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -