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Comparison of the effect of BCAA granules on between decompensated and compensated cirrhosis.
Hepatogastroenterology 2009 Nov-Dec; 56(96):1719-23H

Abstract

BACKGROUND/AIMS

We designed a randomized trial to examine whether increase or preservation of serum albumin levels was attained with administration of branched-chain amino acid (BCAA) granules for compensated cirrhosis, compared with decompensated cirrhosis.

METHODOLOGY

Sixty-five patients with HCV-related cirrhosis with serum albumin level less than 4.0 g/dl were enrolled in this study. Half of the patients were randomly assigned to receive 14.22 g/day of BCAA granules orally, and half were assigned to a control group. Patients were evaluated at entry and at 1-year intervals for at least 2 years. The parameters were divided into 3 categories. Class 1 was decompensated cirrhosis with serum albumin level less than 3.5 mg/dl. Class 2 was compensated cirrhosis with serum albumin level over 3.6 mg/dl and molar ratio of BCAA to tyrosine (BTR) less than 4. Class 3 was compensated cirrhosis with serum albumin level over 3.6 mg/dl and BTR over 4.

RESULTS

In class 1 and class 2, the BCAA group exhibited significantly higher rates of maintaining serum albumin level than the control group for 2 years. In contrast, there was no significant difference between the BCAA group and control group in rate of maintaining serum albumin levels in class 3.

CONCLUSIONS

Those results suggested that if cirrhotic patients were in the compensated stage at the entry but with lower BTR, as for decompensated cirrhosis, oral BCAA supplementation might be effective in maintaining serum albumin level for 2 years.

Authors+Show Affiliations

Department of Hepatology, Graduate School of Medicine, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan. daiki@med.osaka-cu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

20214224

Citation

Habu, Daiki, et al. "Comparison of the Effect of BCAA Granules On Between Decompensated and Compensated Cirrhosis." Hepato-gastroenterology, vol. 56, no. 96, 2009, pp. 1719-23.
Habu D, Nishiguchi S, Nakatani S, et al. Comparison of the effect of BCAA granules on between decompensated and compensated cirrhosis. Hepatogastroenterology. 2009;56(96):1719-23.
Habu, D., Nishiguchi, S., Nakatani, S., Lee, C., Enomoto, M., Tamori, A., ... Shiomi, S. (2009). Comparison of the effect of BCAA granules on between decompensated and compensated cirrhosis. Hepato-gastroenterology, 56(96), pp. 1719-23.
Habu D, et al. Comparison of the Effect of BCAA Granules On Between Decompensated and Compensated Cirrhosis. Hepatogastroenterology. 2009;56(96):1719-23. PubMed PMID: 20214224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the effect of BCAA granules on between decompensated and compensated cirrhosis. AU - Habu,Daiki, AU - Nishiguchi,Shuhei, AU - Nakatani,Shinji, AU - Lee,Chulyoo, AU - Enomoto,Masaru, AU - Tamori,Akihiro, AU - Takeda,Tadashi, AU - Ohfuji,Satoko, AU - Fukushima,Wakaba, AU - Tanaka,Takashi, AU - Kawamura,Etsuji, AU - Shiomi,Susumu, PY - 2010/3/11/entrez PY - 2010/3/11/pubmed PY - 2010/3/26/medline SP - 1719 EP - 23 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 56 IS - 96 N2 - BACKGROUND/AIMS: We designed a randomized trial to examine whether increase or preservation of serum albumin levels was attained with administration of branched-chain amino acid (BCAA) granules for compensated cirrhosis, compared with decompensated cirrhosis. METHODOLOGY: Sixty-five patients with HCV-related cirrhosis with serum albumin level less than 4.0 g/dl were enrolled in this study. Half of the patients were randomly assigned to receive 14.22 g/day of BCAA granules orally, and half were assigned to a control group. Patients were evaluated at entry and at 1-year intervals for at least 2 years. The parameters were divided into 3 categories. Class 1 was decompensated cirrhosis with serum albumin level less than 3.5 mg/dl. Class 2 was compensated cirrhosis with serum albumin level over 3.6 mg/dl and molar ratio of BCAA to tyrosine (BTR) less than 4. Class 3 was compensated cirrhosis with serum albumin level over 3.6 mg/dl and BTR over 4. RESULTS: In class 1 and class 2, the BCAA group exhibited significantly higher rates of maintaining serum albumin level than the control group for 2 years. In contrast, there was no significant difference between the BCAA group and control group in rate of maintaining serum albumin levels in class 3. CONCLUSIONS: Those results suggested that if cirrhotic patients were in the compensated stage at the entry but with lower BTR, as for decompensated cirrhosis, oral BCAA supplementation might be effective in maintaining serum albumin level for 2 years. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/20214224/Comparison_of_the_effect_of_BCAA_granules_on_between_decompensated_and_compensated_cirrhosis_ L2 - https://medlineplus.gov/cirrhosis.html DB - PRIME DP - Unbound Medicine ER -