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Stomach-specific drug delivery of 5-fluorouracil using ethylcellulose floating microspheres.
Pharm Dev Technol. 2010 Mar-Apr; 15(2):154-61.PD

Abstract

A multiple-unit-type oral floating dosage form (FDF) of 5-Fluorouracil (5-FU) was developed to prolong gastric residence time for the treatment of stomach cancer. The floating microspheres were prepared by solvent evaporation method. The prepared microspheres were characterized for their micromeretic properties, floating behavior and entrapment efficiency; as well by Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), thin layer chromatography (TLC) and scanning electron microscopy (SEM). The in vitro release studies and floating behavior were performed in HCl buffer pH 1.2, Phosphate buffer pH 4.5 and in Simulated Gastric Fluid (SGF). The best fit release kinetics was achieved with Higuchi plot. The yields of preparation were very high and low entrapment efficiencies were noticed with larger particle size for all the formulations. Mean particle size, entrapment efficiency and production yield were highly influenced by polymer concentration. It was concluded from the present investigation that porous Ethylcellulose microspheres are promising controlled release as well as stomach targeted carriers for 5-FU.

Authors+Show Affiliations

Department of Pharmaceutics, PES College of Pharmacy, Hanumanthnagar, Bangalore, India. subhashvaghani@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20214502

Citation

Vaghani, Subhash, et al. "Stomach-specific Drug Delivery of 5-fluorouracil Using Ethylcellulose Floating Microspheres." Pharmaceutical Development and Technology, vol. 15, no. 2, 2010, pp. 154-61.
Vaghani S, Vasanti S, Chaturvedi K, et al. Stomach-specific drug delivery of 5-fluorouracil using ethylcellulose floating microspheres. Pharm Dev Technol. 2010;15(2):154-61.
Vaghani, S., Vasanti, S., Chaturvedi, K., Satish, C. S., & Jivani, N. P. (2010). Stomach-specific drug delivery of 5-fluorouracil using ethylcellulose floating microspheres. Pharmaceutical Development and Technology, 15(2), 154-61. https://doi.org/10.3109/10837450903085392
Vaghani S, et al. Stomach-specific Drug Delivery of 5-fluorouracil Using Ethylcellulose Floating Microspheres. Pharm Dev Technol. 2010 Mar-Apr;15(2):154-61. PubMed PMID: 20214502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stomach-specific drug delivery of 5-fluorouracil using ethylcellulose floating microspheres. AU - Vaghani,Subhash, AU - Vasanti,S, AU - Chaturvedi,Kiran, AU - Satish,C S, AU - Jivani,N P, PY - 2010/3/11/entrez PY - 2010/3/11/pubmed PY - 2010/9/24/medline SP - 154 EP - 61 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 15 IS - 2 N2 - A multiple-unit-type oral floating dosage form (FDF) of 5-Fluorouracil (5-FU) was developed to prolong gastric residence time for the treatment of stomach cancer. The floating microspheres were prepared by solvent evaporation method. The prepared microspheres were characterized for their micromeretic properties, floating behavior and entrapment efficiency; as well by Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), thin layer chromatography (TLC) and scanning electron microscopy (SEM). The in vitro release studies and floating behavior were performed in HCl buffer pH 1.2, Phosphate buffer pH 4.5 and in Simulated Gastric Fluid (SGF). The best fit release kinetics was achieved with Higuchi plot. The yields of preparation were very high and low entrapment efficiencies were noticed with larger particle size for all the formulations. Mean particle size, entrapment efficiency and production yield were highly influenced by polymer concentration. It was concluded from the present investigation that porous Ethylcellulose microspheres are promising controlled release as well as stomach targeted carriers for 5-FU. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/20214502/Stomach_specific_drug_delivery_of_5_fluorouracil_using_ethylcellulose_floating_microspheres_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450903085392 DB - PRIME DP - Unbound Medicine ER -