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Estimating GFR in children with 99mTc-DTPA renography: a comparison with single-sample 51Cr-EDTA clearance.
Clin Physiol Funct Imaging. 2010 May; 30(3):169-74.CP

Abstract

Glomerular filtration rate (GFR) measurement by (51)Cr-ethylenediaminetetraacetic acid (EDTA) and blood sampling in children is usually cumbersome for the patient, parents and laboratory technicians. We have previously developed a method accurately estimating GFR in adults. The aim of the present study was to evaluate the accuracy of this non-invasive method in children. We calculated GFR from (99m)Tc-diethylene triamine pentaacetic acid (DTPA) renography and compared with (51)Cr-EDTA plasma clearance of 29 children between the age of 1 month and 12 years (mean 4.7 years). The correlation between (99m)Tc-DTPA renography and (51)Cr-EDTA plasma clearance was for all children R = 0.96 (n = 29, P<0.0001), for children above 2 years of age R = 0.96 (n = 18, P<0.0001) and for children <2 years R = 0.84 (n = 11, P<0.001). We conclude that assessment of GFR from (99m)Tc-DTPA renography is reliable and comparable to GFR calculated from (51)Cr-EDTA plasma clearance. Because our method is non-invasive and only takes 21 min, it may be preferable in many cases where an assessment of renal function is needed in children especially when renography is performed anyhow.

Authors+Show Affiliations

Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, Rigshospitalet, Denmark. henrik.gutte@rh.regionh.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

20214666

Citation

Gutte, Henrik, et al. "Estimating GFR in Children With 99mTc-DTPA Renography: a Comparison With Single-sample 51Cr-EDTA Clearance." Clinical Physiology and Functional Imaging, vol. 30, no. 3, 2010, pp. 169-74.
Gutte H, Møller ML, Pfeifer AK, et al. Estimating GFR in children with 99mTc-DTPA renography: a comparison with single-sample 51Cr-EDTA clearance. Clin Physiol Funct Imaging. 2010;30(3):169-74.
Gutte, H., Møller, M. L., Pfeifer, A. K., Thorup, J., Borgwardt, L., Borgwardt, L., Kristoffersen, U. S., & Kjaer, A. (2010). Estimating GFR in children with 99mTc-DTPA renography: a comparison with single-sample 51Cr-EDTA clearance. Clinical Physiology and Functional Imaging, 30(3), 169-74. https://doi.org/10.1111/j.1475-097X.2009.00910.x
Gutte H, et al. Estimating GFR in Children With 99mTc-DTPA Renography: a Comparison With Single-sample 51Cr-EDTA Clearance. Clin Physiol Funct Imaging. 2010;30(3):169-74. PubMed PMID: 20214666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estimating GFR in children with 99mTc-DTPA renography: a comparison with single-sample 51Cr-EDTA clearance. AU - Gutte,Henrik, AU - Møller,Michael L, AU - Pfeifer,Andreas K, AU - Thorup,Jørgen, AU - Borgwardt,Line, AU - Borgwardt,Lise, AU - Kristoffersen,Ulrik S, AU - Kjaer,Andreas, Y1 - 2010/02/27/ PY - 2010/3/11/entrez PY - 2010/3/11/pubmed PY - 2010/8/21/medline SP - 169 EP - 74 JF - Clinical physiology and functional imaging JO - Clin Physiol Funct Imaging VL - 30 IS - 3 N2 - Glomerular filtration rate (GFR) measurement by (51)Cr-ethylenediaminetetraacetic acid (EDTA) and blood sampling in children is usually cumbersome for the patient, parents and laboratory technicians. We have previously developed a method accurately estimating GFR in adults. The aim of the present study was to evaluate the accuracy of this non-invasive method in children. We calculated GFR from (99m)Tc-diethylene triamine pentaacetic acid (DTPA) renography and compared with (51)Cr-EDTA plasma clearance of 29 children between the age of 1 month and 12 years (mean 4.7 years). The correlation between (99m)Tc-DTPA renography and (51)Cr-EDTA plasma clearance was for all children R = 0.96 (n = 29, P<0.0001), for children above 2 years of age R = 0.96 (n = 18, P<0.0001) and for children <2 years R = 0.84 (n = 11, P<0.001). We conclude that assessment of GFR from (99m)Tc-DTPA renography is reliable and comparable to GFR calculated from (51)Cr-EDTA plasma clearance. Because our method is non-invasive and only takes 21 min, it may be preferable in many cases where an assessment of renal function is needed in children especially when renography is performed anyhow. SN - 1475-097X UR - https://www.unboundmedicine.com/medline/citation/20214666/Estimating_GFR_in_children_with_99mTc_DTPA_renography:_a_comparison_with_single_sample_51Cr_EDTA_clearance_ L2 - https://doi.org/10.1111/j.1475-097X.2009.00910.x DB - PRIME DP - Unbound Medicine ER -