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Praziquantel efficacy and long-term appraisal of schistosomiasis control in Pemba Island.
Trop Med Int Health. 2010 May; 15(5):614-8.TM

Abstract

OBJECTIVE

To determine whether praziquantel (PZQ) has retained its efficacy against Schistosoma haematobium on Pemba Island after 20 years of mass administration--albeit discontinuous--and to analyse retrospectively the performance of schistosomiasis control programmes.

METHODS

A sample of Pemba schoolchildren was examined before and after PZQ treatment by urine filtration, macro- and micro-haematuria and viability of excreted eggs.

RESULTS

Although 5% of treated children continued to pass some eggs in the urine up to the seventh week after PZQ administration, none of these eggs was viable, indicating an effective schistosomicidal activity followed by a slow release of dead eggs from host tissues.

CONCLUSION

No signs of PZQ resistance could be detected in the population under study. An overall retrospective analysis of schistosomiasis control activities in Pemba Island revealed that mass drug administration is clearly effective in reducing infection prevalence, but soon after interruption of drug distribution prevalence returns rapidly to pre-intervention levels.

Authors+Show Affiliations

Institute of Cell Biology, National Research Council, Monterotondo, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20214757

Citation

Guidi, A, et al. "Praziquantel Efficacy and Long-term Appraisal of Schistosomiasis Control in Pemba Island." Tropical Medicine & International Health : TM & IH, vol. 15, no. 5, 2010, pp. 614-8.
Guidi A, Andolina C, Makame Ame S, et al. Praziquantel efficacy and long-term appraisal of schistosomiasis control in Pemba Island. Trop Med Int Health. 2010;15(5):614-8.
Guidi, A., Andolina, C., Makame Ame, S., Albonico, M., Cioli, D., & Juma Haji, H. (2010). Praziquantel efficacy and long-term appraisal of schistosomiasis control in Pemba Island. Tropical Medicine & International Health : TM & IH, 15(5), 614-8. https://doi.org/10.1111/j.1365-3156.2010.02488.x
Guidi A, et al. Praziquantel Efficacy and Long-term Appraisal of Schistosomiasis Control in Pemba Island. Trop Med Int Health. 2010;15(5):614-8. PubMed PMID: 20214757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Praziquantel efficacy and long-term appraisal of schistosomiasis control in Pemba Island. AU - Guidi,A, AU - Andolina,C, AU - Makame Ame,S, AU - Albonico,M, AU - Cioli,D, AU - Juma Haji,H, Y1 - 2010/03/01/ PY - 2010/3/11/entrez PY - 2010/3/11/pubmed PY - 2010/5/21/medline SP - 614 EP - 8 JF - Tropical medicine & international health : TM & IH JO - Trop Med Int Health VL - 15 IS - 5 N2 - OBJECTIVE: To determine whether praziquantel (PZQ) has retained its efficacy against Schistosoma haematobium on Pemba Island after 20 years of mass administration--albeit discontinuous--and to analyse retrospectively the performance of schistosomiasis control programmes. METHODS: A sample of Pemba schoolchildren was examined before and after PZQ treatment by urine filtration, macro- and micro-haematuria and viability of excreted eggs. RESULTS: Although 5% of treated children continued to pass some eggs in the urine up to the seventh week after PZQ administration, none of these eggs was viable, indicating an effective schistosomicidal activity followed by a slow release of dead eggs from host tissues. CONCLUSION: No signs of PZQ resistance could be detected in the population under study. An overall retrospective analysis of schistosomiasis control activities in Pemba Island revealed that mass drug administration is clearly effective in reducing infection prevalence, but soon after interruption of drug distribution prevalence returns rapidly to pre-intervention levels. SN - 1365-3156 UR - https://www.unboundmedicine.com/medline/citation/20214757/Praziquantel_efficacy_and_long_term_appraisal_of_schistosomiasis_control_in_Pemba_Island_ L2 - https://doi.org/10.1111/j.1365-3156.2010.02488.x DB - PRIME DP - Unbound Medicine ER -