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Metformin induces reductions in plasma cobalamin and haptocorrin bound cobalamin levels in elderly diabetic patients.
Clin Biochem. 2010 Jun; 43(9):759-60.CB

Abstract

OBJECTIVE

To study the effect of short term metformin therapy on plasma levels of cobalamin, cobalamin related metabolites and cobalamin binding proteins in elderly patients.

DESIGN AND METHODS

Twenty patients with type 2 diabetes were assigned to receive metformin or not for 3 months. Cobalamin and its metabolites were measured before and after metformin therapy.

RESULTS

As compared to baseline measures, there was a metformin therapy specific significant decrease in plasma levels of total cobalamin, total haptocorrin and haptocorrin bound cobalamin.

CONCLUSIONS

Plasma total cobalamin and haptocorrin bound cobalamin levels are reduced by short term metformin therapy in an elderly diabetic population. Larger scale, longer term studies are necessary to determine if there is an unequivocal decrease in functional measures of cobalamin status.

Authors+Show Affiliations

Diabetes Centre, Vancouver General Hospital, Vancouver, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

20214894

Citation

Leung, Sharon, et al. "Metformin Induces Reductions in Plasma Cobalamin and Haptocorrin Bound Cobalamin Levels in Elderly Diabetic Patients." Clinical Biochemistry, vol. 43, no. 9, 2010, pp. 759-60.
Leung S, Mattman A, Snyder F, et al. Metformin induces reductions in plasma cobalamin and haptocorrin bound cobalamin levels in elderly diabetic patients. Clin Biochem. 2010;43(9):759-60.
Leung, S., Mattman, A., Snyder, F., Kassam, R., Meneilly, G., & Nexo, E. (2010). Metformin induces reductions in plasma cobalamin and haptocorrin bound cobalamin levels in elderly diabetic patients. Clinical Biochemistry, 43(9), 759-60. https://doi.org/10.1016/j.clinbiochem.2010.02.011
Leung S, et al. Metformin Induces Reductions in Plasma Cobalamin and Haptocorrin Bound Cobalamin Levels in Elderly Diabetic Patients. Clin Biochem. 2010;43(9):759-60. PubMed PMID: 20214894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metformin induces reductions in plasma cobalamin and haptocorrin bound cobalamin levels in elderly diabetic patients. AU - Leung,Sharon, AU - Mattman,Andre, AU - Snyder,Floyd, AU - Kassam,Rosemin, AU - Meneilly,Graydon, AU - Nexo,Ebba, Y1 - 2010/03/06/ PY - 2009/12/10/received PY - 2010/02/24/revised PY - 2010/02/26/accepted PY - 2010/3/11/entrez PY - 2010/3/11/pubmed PY - 2010/8/19/medline SP - 759 EP - 60 JF - Clinical biochemistry JO - Clin Biochem VL - 43 IS - 9 N2 - OBJECTIVE: To study the effect of short term metformin therapy on plasma levels of cobalamin, cobalamin related metabolites and cobalamin binding proteins in elderly patients. DESIGN AND METHODS: Twenty patients with type 2 diabetes were assigned to receive metformin or not for 3 months. Cobalamin and its metabolites were measured before and after metformin therapy. RESULTS: As compared to baseline measures, there was a metformin therapy specific significant decrease in plasma levels of total cobalamin, total haptocorrin and haptocorrin bound cobalamin. CONCLUSIONS: Plasma total cobalamin and haptocorrin bound cobalamin levels are reduced by short term metformin therapy in an elderly diabetic population. Larger scale, longer term studies are necessary to determine if there is an unequivocal decrease in functional measures of cobalamin status. SN - 1873-2933 UR - https://www.unboundmedicine.com/medline/citation/20214894/Metformin_induces_reductions_in_plasma_cobalamin_and_haptocorrin_bound_cobalamin_levels_in_elderly_diabetic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(10)00089-5 DB - PRIME DP - Unbound Medicine ER -