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Evidence of interaction between type 2 diabetes susceptibility genes and dietary fat intake for adiposity and glucose homeostasis-related phenotypes.
J Nutrigenet Nutrigenomics 2009; 2(4-5):225-34JN

Abstract

BACKGROUND/AIMS

Genome-wide association studies have led to the identification of several susceptibility genes for type 2 diabetes mellitus (T2DM). The objective of this study was to test the hypothesis that the associations between single nucleotide polymorphisms (SNPs) in these genes and adiposity and glucose homeostasis-related phenotypes are influenced by dietary fat intake.

METHODS

Thirty-three SNPs in 9 T2DM genes (CDKAL1, CDKN2A/B, HHEX, HNF1B, IGF2BP2, KCNJ11, SLC30A8, TCF7L2 and WFS1) were tested in a maximum of 669 subjects from the Quebec Family Study. Subjects were measured for several adiposity indices and underwent a 75-gram oral glucose tolerance test. Total fat intake was estimated from a 3-day dietary record.

RESULTS

We observed 13 significant (p < or = 0.01) SNP-dietary fat interactions. Among them, IGF2BP2 rs4402960, alone or in interaction with dietary fat intake, influenced abdominal total fat (ATF: SNP effect, p = 0.006, interaction effect, p = 0.009) and abdominal visceral fat (AVF: SNP effect, p = 0.007, interaction effect, p = 0.01). Similarly, TCF7L2 rs12573128 alone or in interaction with dietary fat intake, influenced insulin sensitivity (SNP effect and interaction effect, p < or = 0.008) and glucose tolerance (SNP effect p < or= 0.009 and interaction effect, p < or = 0.01).

CONCLUSION

These results suggest that gene-dietary fat interactions may influence glucose homeostasis-related phenotypes and play an important role in determining the increased risk of diabetes associated with the T2DM susceptibility genes.

Authors+Show Affiliations

Department of Preventive Medicine, Laval University, Québec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20215779

Citation

Ruchat, Stephanie-May, et al. "Evidence of Interaction Between Type 2 Diabetes Susceptibility Genes and Dietary Fat Intake for Adiposity and Glucose Homeostasis-related Phenotypes." Journal of Nutrigenetics and Nutrigenomics, vol. 2, no. 4-5, 2009, pp. 225-34.
Ruchat SM, Elks CE, Loos RJ, et al. Evidence of interaction between type 2 diabetes susceptibility genes and dietary fat intake for adiposity and glucose homeostasis-related phenotypes. J Nutrigenet Nutrigenomics. 2009;2(4-5):225-34.
Ruchat, S. M., Elks, C. E., Loos, R. J., Vohl, M. C., Weisnagel, S. J., Rankinen, T., ... Pérusse, L. (2009). Evidence of interaction between type 2 diabetes susceptibility genes and dietary fat intake for adiposity and glucose homeostasis-related phenotypes. Journal of Nutrigenetics and Nutrigenomics, 2(4-5), pp. 225-34. doi:10.1159/000259341.
Ruchat SM, et al. Evidence of Interaction Between Type 2 Diabetes Susceptibility Genes and Dietary Fat Intake for Adiposity and Glucose Homeostasis-related Phenotypes. J Nutrigenet Nutrigenomics. 2009;2(4-5):225-34. PubMed PMID: 20215779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence of interaction between type 2 diabetes susceptibility genes and dietary fat intake for adiposity and glucose homeostasis-related phenotypes. AU - Ruchat,Stephanie-May, AU - Elks,Cathy E, AU - Loos,Ruth J F, AU - Vohl,Marie-Claude, AU - Weisnagel,S John, AU - Rankinen,Tuomo, AU - Bouchard,Claude, AU - Pérusse,Louis, Y1 - 2010/03/09/ PY - 2009/09/22/received PY - 2009/11/09/accepted PY - 2010/3/11/entrez PY - 2010/3/11/pubmed PY - 2010/8/17/medline SP - 225 EP - 34 JF - Journal of nutrigenetics and nutrigenomics JO - J Nutrigenet Nutrigenomics VL - 2 IS - 4-5 N2 - BACKGROUND/AIMS: Genome-wide association studies have led to the identification of several susceptibility genes for type 2 diabetes mellitus (T2DM). The objective of this study was to test the hypothesis that the associations between single nucleotide polymorphisms (SNPs) in these genes and adiposity and glucose homeostasis-related phenotypes are influenced by dietary fat intake. METHODS: Thirty-three SNPs in 9 T2DM genes (CDKAL1, CDKN2A/B, HHEX, HNF1B, IGF2BP2, KCNJ11, SLC30A8, TCF7L2 and WFS1) were tested in a maximum of 669 subjects from the Quebec Family Study. Subjects were measured for several adiposity indices and underwent a 75-gram oral glucose tolerance test. Total fat intake was estimated from a 3-day dietary record. RESULTS: We observed 13 significant (p < or = 0.01) SNP-dietary fat interactions. Among them, IGF2BP2 rs4402960, alone or in interaction with dietary fat intake, influenced abdominal total fat (ATF: SNP effect, p = 0.006, interaction effect, p = 0.009) and abdominal visceral fat (AVF: SNP effect, p = 0.007, interaction effect, p = 0.01). Similarly, TCF7L2 rs12573128 alone or in interaction with dietary fat intake, influenced insulin sensitivity (SNP effect and interaction effect, p < or = 0.008) and glucose tolerance (SNP effect p < or= 0.009 and interaction effect, p < or = 0.01). CONCLUSION: These results suggest that gene-dietary fat interactions may influence glucose homeostasis-related phenotypes and play an important role in determining the increased risk of diabetes associated with the T2DM susceptibility genes. SN - 1661-6499 UR - https://www.unboundmedicine.com/medline/citation/20215779/Evidence_of_interaction_between_type_2_diabetes_susceptibility_genes_and_dietary_fat_intake_for_adiposity_and_glucose_homeostasis_related_phenotypes_ L2 - https://www.karger.com?DOI=10.1159/000259341 DB - PRIME DP - Unbound Medicine ER -