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Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy.
J Agric Food Chem. 2010 Apr 14; 58(7):3933-9.JA

Abstract

The fate of anthocyanins, ellagic acid, and ellagitannins was studied following the consumption of 300 g of raspberries by healthy human volunteers and subjects with an ileostomy. Postingestion plasma and urine from the former and ileal fluid and urine from the latter group were collected and analyzed by HPLC-PDA-MS(2). Plasma from the healthy volunteers did not contain detectable quantities of either the native raspberry polyphenolics or their metabolites. The three main raspberry anthocyanins were excreted in urine in both healthy and ileostomy volunteers 0-7 h after ingestion, in quantities corresponding to <0.1% of intake. This indicates a low level of absorption in the small intestine. With ileostomy volunteers 40% of anthocyanins and 23% of the ellagitannin sanguiin H-6 were recovered in ileal fluid with the main excretion period being the first 4 h after raspberry consumption. The recovery of ellagic acid in ileal fluid was 241%, indicating hydrolysis of ellagitannins in the stomach and/or the small intestine. Urinary excretion of ellagic acid and an ellagic acid-O-glucuronide was <1% of intake. No intact or conjugated forms of ellagitannins were detected in urine from either healthy subjects or ileostomy volunteers. However, in healthy subjects, but not the ileostomists, ellagitannins were catabolized with the appearance of urolithin A-O-glucuronide, two of its isomers, and urolithin B-O-glucuronide in urine collected 7-48 h after raspberry consumption. There was marked variation in the urolithin profile of individual volunteers, indicating differences in the colonic microflora responsible for ellagitannin degradation.

Authors+Show Affiliations

Graham Kerr Building, Division of Developmental Medicine, Faculty of Medicine, University of Glasgow, Glasgow, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20218618

Citation

González-Barrio, Rocío, et al. "Bioavailability of Anthocyanins and Ellagitannins Following Consumption of Raspberries By Healthy Humans and Subjects With an Ileostomy." Journal of Agricultural and Food Chemistry, vol. 58, no. 7, 2010, pp. 3933-9.
González-Barrio R, Borges G, Mullen W, et al. Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy. J Agric Food Chem. 2010;58(7):3933-9.
González-Barrio, R., Borges, G., Mullen, W., & Crozier, A. (2010). Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy. Journal of Agricultural and Food Chemistry, 58(7), 3933-9. https://doi.org/10.1021/jf100315d
González-Barrio R, et al. Bioavailability of Anthocyanins and Ellagitannins Following Consumption of Raspberries By Healthy Humans and Subjects With an Ileostomy. J Agric Food Chem. 2010 Apr 14;58(7):3933-9. PubMed PMID: 20218618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy. AU - González-Barrio,Rocío, AU - Borges,Gina, AU - Mullen,William, AU - Crozier,Alan, PY - 2010/3/12/entrez PY - 2010/3/12/pubmed PY - 2010/9/2/medline SP - 3933 EP - 9 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 58 IS - 7 N2 - The fate of anthocyanins, ellagic acid, and ellagitannins was studied following the consumption of 300 g of raspberries by healthy human volunteers and subjects with an ileostomy. Postingestion plasma and urine from the former and ileal fluid and urine from the latter group were collected and analyzed by HPLC-PDA-MS(2). Plasma from the healthy volunteers did not contain detectable quantities of either the native raspberry polyphenolics or their metabolites. The three main raspberry anthocyanins were excreted in urine in both healthy and ileostomy volunteers 0-7 h after ingestion, in quantities corresponding to <0.1% of intake. This indicates a low level of absorption in the small intestine. With ileostomy volunteers 40% of anthocyanins and 23% of the ellagitannin sanguiin H-6 were recovered in ileal fluid with the main excretion period being the first 4 h after raspberry consumption. The recovery of ellagic acid in ileal fluid was 241%, indicating hydrolysis of ellagitannins in the stomach and/or the small intestine. Urinary excretion of ellagic acid and an ellagic acid-O-glucuronide was <1% of intake. No intact or conjugated forms of ellagitannins were detected in urine from either healthy subjects or ileostomy volunteers. However, in healthy subjects, but not the ileostomists, ellagitannins were catabolized with the appearance of urolithin A-O-glucuronide, two of its isomers, and urolithin B-O-glucuronide in urine collected 7-48 h after raspberry consumption. There was marked variation in the urolithin profile of individual volunteers, indicating differences in the colonic microflora responsible for ellagitannin degradation. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/20218618/Bioavailability_of_anthocyanins_and_ellagitannins_following_consumption_of_raspberries_by_healthy_humans_and_subjects_with_an_ileostomy_ L2 - https://doi.org/10.1021/jf100315d DB - PRIME DP - Unbound Medicine ER -