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Favourable results in treatment-resistant schizophrenic patients under combination of aripiprazole with clozapine.
World J Biol Psychiatry. 2010 Mar; 11(2 Pt 2):502-5.WJ

Abstract

Clozapine is still the gold standard in treatment-resistant schizophrenia. However, a substantial amount of patients do not fully recover on clozapine monotherapy. Though there is still a lack of randomised controlled studies of combination strategies in treatment-resistant schizophrenia, they are widely used. Aripiprazole is a relatively new therapeutic option due to its partial D2 agonism. Both clozapine and aripiprazole, though having a generally favourable side-effect profile, may lead to insufficient response and might provoke side effects in monotherapy. We report the case of four patients in whom we observed a distinct clinical improvement with respect to positive and negative symptoms without major side effects under a combination of clozapine and aripiprazole. The combination of clozapine action and aripiprazole-mediated D(2) receptor regulation could be responsible for the described favourable effects and for the increase of D(2) receptor blockade after adding aripiprazole to clozapine observed in one patient. A combination of clozapine and aripiprazole may be an effective therapeutic strategy for some schizophrenic patients, leading to a good response with respect to positive and negative symptoms without the occurrence of major side effects.

Authors+Show Affiliations

Division of Biological Psychiatry, Department of Psychiatry and Psychotherapy, Medical University Vienna, Vienna, Austria. nilufar.mossaheb@meduniwien.ac.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

20218805

Citation

Mossaheb, Nilufar, et al. "Favourable Results in Treatment-resistant Schizophrenic Patients Under Combination of Aripiprazole With Clozapine." The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry, vol. 11, no. 2 Pt 2, 2010, pp. 502-5.
Mossaheb N, Spindelegger C, Asenbaum S, et al. Favourable results in treatment-resistant schizophrenic patients under combination of aripiprazole with clozapine. World J Biol Psychiatry. 2010;11(2 Pt 2):502-5.
Mossaheb, N., Spindelegger, C., Asenbaum, S., Fischer, P., & Barnas, C. (2010). Favourable results in treatment-resistant schizophrenic patients under combination of aripiprazole with clozapine. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry, 11(2 Pt 2), 502-5. https://doi.org/10.3109/15622970802269597
Mossaheb N, et al. Favourable Results in Treatment-resistant Schizophrenic Patients Under Combination of Aripiprazole With Clozapine. World J Biol Psychiatry. 2010;11(2 Pt 2):502-5. PubMed PMID: 20218805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Favourable results in treatment-resistant schizophrenic patients under combination of aripiprazole with clozapine. AU - Mossaheb,Nilufar, AU - Spindelegger,Christoph, AU - Asenbaum,Susanne, AU - Fischer,Peter, AU - Barnas,Christian, PY - 2010/3/12/entrez PY - 2010/3/12/pubmed PY - 2010/6/15/medline SP - 502 EP - 5 JF - The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry JO - World J. Biol. Psychiatry VL - 11 IS - 2 Pt 2 N2 - Clozapine is still the gold standard in treatment-resistant schizophrenia. However, a substantial amount of patients do not fully recover on clozapine monotherapy. Though there is still a lack of randomised controlled studies of combination strategies in treatment-resistant schizophrenia, they are widely used. Aripiprazole is a relatively new therapeutic option due to its partial D2 agonism. Both clozapine and aripiprazole, though having a generally favourable side-effect profile, may lead to insufficient response and might provoke side effects in monotherapy. We report the case of four patients in whom we observed a distinct clinical improvement with respect to positive and negative symptoms without major side effects under a combination of clozapine and aripiprazole. The combination of clozapine action and aripiprazole-mediated D(2) receptor regulation could be responsible for the described favourable effects and for the increase of D(2) receptor blockade after adding aripiprazole to clozapine observed in one patient. A combination of clozapine and aripiprazole may be an effective therapeutic strategy for some schizophrenic patients, leading to a good response with respect to positive and negative symptoms without the occurrence of major side effects. SN - 1814-1412 UR - https://www.unboundmedicine.com/medline/citation/20218805/Favourable_results_in_treatment_resistant_schizophrenic_patients_under_combination_of_aripiprazole_with_clozapine_ L2 - http://www.tandfonline.com/doi/full/10.3109/15622970802269597 DB - PRIME DP - Unbound Medicine ER -