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[Parkinson's disease dementia: correlations between clinical, neuropsychological and neuropathological features].
Rev Neurol (Paris). 2010 Jun-Jul; 166(6-7):653-6.RN

Abstract

INTRODUCTION

Cognitive disorders such as deficit of attention and executive and visuoconstructive dysfunctions occur in Parkinson's disease dementia (PDD). Memory impairment is not an early feature and statement not well delimited.

CASE REPORT

A 78-year-old man with PDD underwent neuropsychological assessment and moreover demonstrated memory decline. After death, pathology examination of the brain and immunohistochemy analysis confirmed PD and showed Lewy body pathology (LBP) in the insula, limbic and especially in CA3 hippocampus areas. Hippocampus and gyrus parahippocampic also exhibited neurofibrillary tangles. Lack of senile plaque and lack of beta A4 amyloid deposition were noticeable in the whole brain examination.

CONCLUSION

Severe executive dysfunctions are probably related to LBP and dysfunction in memory process may be related to DNF lesions in medial temporal area.

Links

Publisher Full Text
linkinghub.elsevier.com
em-consulte.com

Authors+Show Affiliations

Kiesmann M
Pôle de gériatrie, HUS, rue Himmerich, Strasbourg, France. Michele.kiesmann@chru-strasbourg.fr
Vogel T
No affiliation info available
Kaltenbach G
No affiliation info available
Mohr M
No affiliation info available

MeSH

AgedBrainDementiaDisease ProgressionHumansLewy BodiesMaleNeuritesNeurofibrillary TanglesNeuropsychological TestsParkinson DiseaseRestless Legs Syndromealpha-Synucleintau Proteins

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

fre

PubMed ID

20219224

Citation

Kiesmann, M, et al. "[Parkinson's Disease Dementia: Correlations Between Clinical, Neuropsychological and Neuropathological Features]." Revue Neurologique, vol. 166, no. 6-7, 2010, pp. 653-6.
Kiesmann M, Vogel T, Kaltenbach G, et al. [Parkinson's disease dementia: correlations between clinical, neuropsychological and neuropathological features]. Rev Neurol (Paris). 2010;166(6-7):653-6.
Kiesmann, M., Vogel, T., Kaltenbach, G., & Mohr, M. (2010). [Parkinson's disease dementia: correlations between clinical, neuropsychological and neuropathological features]. Revue Neurologique, 166(6-7), 653-6. https://doi.org/10.1016/j.neurol.2010.01.005
Kiesmann M, et al. [Parkinson's Disease Dementia: Correlations Between Clinical, Neuropsychological and Neuropathological Features]. Rev Neurol (Paris). 2010 Jun-Jul;166(6-7):653-6. PubMed PMID: 20219224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Parkinson's disease dementia: correlations between clinical, neuropsychological and neuropathological features]. AU - Kiesmann,M, AU - Vogel,T, AU - Kaltenbach,G, AU - Mohr,M, Y1 - 2010/03/10/ PY - 2009/08/22/received PY - 2009/10/30/revised PY - 2010/01/29/accepted PY - 2010/3/12/entrez PY - 2010/3/12/pubmed PY - 2010/9/14/medline SP - 653 EP - 6 JF - Revue neurologique JO - Rev Neurol (Paris) VL - 166 IS - 6-7 N2 - INTRODUCTION: Cognitive disorders such as deficit of attention and executive and visuoconstructive dysfunctions occur in Parkinson's disease dementia (PDD). Memory impairment is not an early feature and statement not well delimited. CASE REPORT: A 78-year-old man with PDD underwent neuropsychological assessment and moreover demonstrated memory decline. After death, pathology examination of the brain and immunohistochemy analysis confirmed PD and showed Lewy body pathology (LBP) in the insula, limbic and especially in CA3 hippocampus areas. Hippocampus and gyrus parahippocampic also exhibited neurofibrillary tangles. Lack of senile plaque and lack of beta A4 amyloid deposition were noticeable in the whole brain examination. CONCLUSION: Severe executive dysfunctions are probably related to LBP and dysfunction in memory process may be related to DNF lesions in medial temporal area. SN - 0035-3787 UR - https://www.unboundmedicine.com/medline/citation/20219224/[Parkinson's_disease_dementia:_correlations_between_clinical_neuropsychological_and_neuropathological_features]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0035-3787(10)00034-2 DB - PRIME DP - Unbound Medicine ER -