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Intake of fish and marine n-3 fatty acids in relation to coronary calcification: the Rotterdam Study.
Am J Clin Nutr. 2010 May; 91(5):1317-23.AJ

Abstract

BACKGROUND

Epidemiologic and experimental data suggest a cardioprotective effect of n-3 (omega-3) fatty acids from fish [eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA)].

OBJECTIVE

The objective was to examine the association of fish and EPA plus DHA intakes with coronary calcification in a general older population.

DESIGN

Diet was assessed between 1990 and 1993 by using a semiquantitative 170-item food-frequency questionnaire. Coronary calcification was assessed approximately 7 y later by electron-beam computed tomography in 1570 asymptomatic cardiac subjects with complete dietary data (44% men, mean age of 64 y). Calcium scores according to Agatston's method were divided into < or = 10 (no/minimal coronary calcification), 11-400 (mild/moderate calcification), and > 400 (severe calcification). Prevalence ratios (PRs) for mild/moderate and severe calcification were obtained in categories of fish and EPA plus DHA intake. PRs were adjusted for age, sex, body mass index, diabetes mellitus, socioeconomic status, smoking, alcohol intake, physical activity, and dietary factors.

RESULTS

Subjects with a fish intake > 19 g/d had a significantly lower prevalence of mild/moderate calcification (PR: 0.87; 95% CI: 0.78, 0.98; full model) than did subjects who consumed no fish. Subjects with a high fish intake also had a lower prevalence of severe calcification (PR: 0.88; 95% CI: 0.74, 1.04), which was borderline statistically significant. EPA plus DHA intake showed no significant associations (PR: 0.93 and 0.97, respectively; P > 0.05).

CONCLUSIONS

We found a weak inverse association between fish intake and coronary calcification. If confirmed in other population-based studies, more research is warranted to determine which components in fish can inhibit vascular calcification.

Authors+Show Affiliations

Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20219958

Citation

Heine-Bröring, Renate C., et al. "Intake of Fish and Marine N-3 Fatty Acids in Relation to Coronary Calcification: the Rotterdam Study." The American Journal of Clinical Nutrition, vol. 91, no. 5, 2010, pp. 1317-23.
Heine-Bröring RC, Brouwer IA, Proença RV, et al. Intake of fish and marine n-3 fatty acids in relation to coronary calcification: the Rotterdam Study. Am J Clin Nutr. 2010;91(5):1317-23.
Heine-Bröring, R. C., Brouwer, I. A., Proença, R. V., van Rooij, F. J., Hofman, A., Oudkerk, M., Witteman, J. C., & Geleijnse, J. M. (2010). Intake of fish and marine n-3 fatty acids in relation to coronary calcification: the Rotterdam Study. The American Journal of Clinical Nutrition, 91(5), 1317-23. https://doi.org/10.3945/ajcn.2009.28416
Heine-Bröring RC, et al. Intake of Fish and Marine N-3 Fatty Acids in Relation to Coronary Calcification: the Rotterdam Study. Am J Clin Nutr. 2010;91(5):1317-23. PubMed PMID: 20219958.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of fish and marine n-3 fatty acids in relation to coronary calcification: the Rotterdam Study. AU - Heine-Bröring,Renate C, AU - Brouwer,Ingeborg A, AU - Proença,Rozemarijn Vliegenthart, AU - van Rooij,Frank J A, AU - Hofman,Albert, AU - Oudkerk,Matthijs, AU - Witteman,Jacqueline C M, AU - Geleijnse,Johanna M, Y1 - 2010/03/10/ PY - 2010/3/12/entrez PY - 2010/3/12/pubmed PY - 2010/5/29/medline SP - 1317 EP - 23 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 91 IS - 5 N2 - BACKGROUND: Epidemiologic and experimental data suggest a cardioprotective effect of n-3 (omega-3) fatty acids from fish [eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA)]. OBJECTIVE: The objective was to examine the association of fish and EPA plus DHA intakes with coronary calcification in a general older population. DESIGN: Diet was assessed between 1990 and 1993 by using a semiquantitative 170-item food-frequency questionnaire. Coronary calcification was assessed approximately 7 y later by electron-beam computed tomography in 1570 asymptomatic cardiac subjects with complete dietary data (44% men, mean age of 64 y). Calcium scores according to Agatston's method were divided into < or = 10 (no/minimal coronary calcification), 11-400 (mild/moderate calcification), and > 400 (severe calcification). Prevalence ratios (PRs) for mild/moderate and severe calcification were obtained in categories of fish and EPA plus DHA intake. PRs were adjusted for age, sex, body mass index, diabetes mellitus, socioeconomic status, smoking, alcohol intake, physical activity, and dietary factors. RESULTS: Subjects with a fish intake > 19 g/d had a significantly lower prevalence of mild/moderate calcification (PR: 0.87; 95% CI: 0.78, 0.98; full model) than did subjects who consumed no fish. Subjects with a high fish intake also had a lower prevalence of severe calcification (PR: 0.88; 95% CI: 0.74, 1.04), which was borderline statistically significant. EPA plus DHA intake showed no significant associations (PR: 0.93 and 0.97, respectively; P > 0.05). CONCLUSIONS: We found a weak inverse association between fish intake and coronary calcification. If confirmed in other population-based studies, more research is warranted to determine which components in fish can inhibit vascular calcification. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20219958/Intake_of_fish_and_marine_n_3_fatty_acids_in_relation_to_coronary_calcification:_the_Rotterdam_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.28416 DB - PRIME DP - Unbound Medicine ER -