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The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression.

Abstract

OBJECTIVE

The Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene is associated with geriatric depression. In studies of younger adults without depression, met allele carriers exhibit smaller hippocampal volumes and have poorer performance on neuropsychological tests. The authors examined the relationship between the BDNF gene and hippocampal volumes in depressed and nondepressed older individuals and its relationship with memory functions mediated by the hippocampus.

DESIGN

One hundred seventy-six elderly depressed white participants and 88 nondepressed participants completed clinical assessments, neuropsychological testing, and provided blood samples for genotyping. One hundred seventy-three participants also underwent brain magnetic resonance imaging. Statistical modeling tested the relationship between genotype and hippocampal volume and function while controlling for diagnosis and other covariates.

RESULTS

BDNF genotype was not associated with a difference in performance on tests mediated by the hippocampus, including word list learning, prose recall, nonverbal memory, or digit span. After controlling for covariates, BDNF genotype was not significantly associated with hippocampal volume (F[1, 171] = 1.10, p = 0.30).

CONCLUSION

Despite different findings in younger populations, the BDNF Val66Met polymorphism is not significantly associated with hippocampal volume or function in a geriatric population. The authors hypothesize that other factors may have a stronger effect on hippocampal structure in older individuals and that the association between the Val66Met polymorphism and geriatric depression is mediated through other mechanisms.

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  • Authors+Show Affiliations

    ,

    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA. sophiya.benjamin@duke.edu

    , , , , ,

    Source

    MeSH

    Aged
    Alleles
    Brain-Derived Neurotrophic Factor
    Cognition
    Depression
    Female
    Genetic Predisposition to Disease
    Hippocampus
    Humans
    Middle Aged
    Polymorphism, Genetic
    Psychomotor Performance

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    20220593

    Citation

    Benjamin, Sophiya, et al. "The Brain-derived Neurotrophic Factor Val66Met Polymorphism, Hippocampal Volume, and Cognitive Function in Geriatric Depression." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, vol. 18, no. 4, 2010, pp. 323-31.
    Benjamin S, McQuoid DR, Potter GG, et al. The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression. Am J Geriatr Psychiatry. 2010;18(4):323-31.
    Benjamin, S., McQuoid, D. R., Potter, G. G., Payne, M. E., MacFall, J. R., Steffens, D. C., & Taylor, W. D. (2010). The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 18(4), pp. 323-31. doi:10.1097/JGP.0b013e3181cabd2b.
    Benjamin S, et al. The Brain-derived Neurotrophic Factor Val66Met Polymorphism, Hippocampal Volume, and Cognitive Function in Geriatric Depression. Am J Geriatr Psychiatry. 2010;18(4):323-31. PubMed PMID: 20220593.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The brain-derived neurotrophic factor Val66Met polymorphism, hippocampal volume, and cognitive function in geriatric depression. AU - Benjamin,Sophiya, AU - McQuoid,Douglas R, AU - Potter,Guy G, AU - Payne,Martha E, AU - MacFall,James R, AU - Steffens,David C, AU - Taylor,Warren D, PY - 2010/3/12/entrez PY - 2010/3/12/pubmed PY - 2010/6/4/medline SP - 323 EP - 31 JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry JO - Am J Geriatr Psychiatry VL - 18 IS - 4 N2 - OBJECTIVE: The Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene is associated with geriatric depression. In studies of younger adults without depression, met allele carriers exhibit smaller hippocampal volumes and have poorer performance on neuropsychological tests. The authors examined the relationship between the BDNF gene and hippocampal volumes in depressed and nondepressed older individuals and its relationship with memory functions mediated by the hippocampus. DESIGN: One hundred seventy-six elderly depressed white participants and 88 nondepressed participants completed clinical assessments, neuropsychological testing, and provided blood samples for genotyping. One hundred seventy-three participants also underwent brain magnetic resonance imaging. Statistical modeling tested the relationship between genotype and hippocampal volume and function while controlling for diagnosis and other covariates. RESULTS: BDNF genotype was not associated with a difference in performance on tests mediated by the hippocampus, including word list learning, prose recall, nonverbal memory, or digit span. After controlling for covariates, BDNF genotype was not significantly associated with hippocampal volume (F[1, 171] = 1.10, p = 0.30). CONCLUSION: Despite different findings in younger populations, the BDNF Val66Met polymorphism is not significantly associated with hippocampal volume or function in a geriatric population. The authors hypothesize that other factors may have a stronger effect on hippocampal structure in older individuals and that the association between the Val66Met polymorphism and geriatric depression is mediated through other mechanisms. SN - 1545-7214 UR - https://www.unboundmedicine.com/medline/citation/20220593/The_brain_derived_neurotrophic_factor_Val66Met_polymorphism_hippocampal_volume_and_cognitive_function_in_geriatric_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1064-7481(12)60194-8 DB - PRIME DP - Unbound Medicine ER -