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Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients.
Arch Physiol Biochem. 2010 May; 116(2):57-62.AP

Abstract

BACKGROUND

Retinol-binding protein 4 (RBP4) is secreted by adipocytes and by the liver and modulates insulin sensitivity in animal models. However, controversial data exist regarding the association of serum levels of RBP4 with insulin resistance in humans. Obesity confers a major risk to develop insulin resistance.

AIM

Therefore, we investigated RBP4 levels in non-diabetic obese patients and analysed the association with insulin sensitivity and other metabolic markers.

SUBJECTS AND METHODS

Glucose tolerance was assessed by oral glucose tolerance tests and 70 normal glucose tolerant patients (36 women, 34 men; body mass index >30 kg/m(2)) were included in our study. We compared the serum level of RBP4 (measured by ELISA) with clinical features (age, sex, BMI, waist-to-hip-ratio, blood pressure) and laboratory findings (total cholesterol, triglycerides, fasting glucose, 2-hour glucose, fasting insulin, HOMA-IR and HOMA-B). The associations between RBP4 and the above mentioned variables were assessed using multiple linear regression models.

RESULTS

The mean age (+/-SD) of the subjects included was 48.1 (+/- 12.3) years and the mean BMI 41.6 (+/- 7.4) kg/m(2). We found significantly higher RBP4 levels in men (53.0 +/- 20.8 microg/ml) than in women (39.7 +/- 12.3 microg/ml) (p = 0.0013). However, age and sex-adjusted multiple linear regression models showed no significant association of serum RBP4 levels with BMI, waist-to-hip-ratio, blood pressure, cholesterol, triglycerides, fasting glucose, 2-hour glucose, insulin resistance (as assessed by HOMA-IR), or insulin secretion (as assessed by HOMA-B).

CONCLUSION

Our data show higher RBP4 levels in obese men than in obese women. However, there was no association of RBP4 levels with insulin resistance or other components of the metabolic syndrome. We conclude that obesity might already be associated with elevated RBP4 levels which then show no additional correlation with metabolic markers.

Authors+Show Affiliations

Department of Endocrinology, Diabetes and Rheumatology, University Hospital Düsseldorf, Moorenstrasse 5, Düsseldorf, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20222849

Citation

Ulgen, Fatma, et al. "Association of Serum Levels of Retinol-binding Protein 4 With Male Sex but Not With Insulin Resistance in Obese Patients." Archives of Physiology and Biochemistry, vol. 116, no. 2, 2010, pp. 57-62.
Ulgen F, Herder C, Kühn MC, et al. Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients. Arch Physiol Biochem. 2010;116(2):57-62.
Ulgen, F., Herder, C., Kühn, M. C., Willenberg, H. S., Schott, M., Scherbaum, W. A., & Schinner, S. (2010). Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients. Archives of Physiology and Biochemistry, 116(2), 57-62. https://doi.org/10.3109/13813451003631421
Ulgen F, et al. Association of Serum Levels of Retinol-binding Protein 4 With Male Sex but Not With Insulin Resistance in Obese Patients. Arch Physiol Biochem. 2010;116(2):57-62. PubMed PMID: 20222849.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of serum levels of retinol-binding protein 4 with male sex but not with insulin resistance in obese patients. AU - Ulgen,Fatma, AU - Herder,Christian, AU - Kühn,Markus C, AU - Willenberg,Holger S, AU - Schott,Matthias, AU - Scherbaum,Werner A, AU - Schinner,Sven, PY - 2010/3/13/entrez PY - 2010/3/13/pubmed PY - 2010/7/22/medline SP - 57 EP - 62 JF - Archives of physiology and biochemistry JO - Arch Physiol Biochem VL - 116 IS - 2 N2 - BACKGROUND: Retinol-binding protein 4 (RBP4) is secreted by adipocytes and by the liver and modulates insulin sensitivity in animal models. However, controversial data exist regarding the association of serum levels of RBP4 with insulin resistance in humans. Obesity confers a major risk to develop insulin resistance. AIM: Therefore, we investigated RBP4 levels in non-diabetic obese patients and analysed the association with insulin sensitivity and other metabolic markers. SUBJECTS AND METHODS: Glucose tolerance was assessed by oral glucose tolerance tests and 70 normal glucose tolerant patients (36 women, 34 men; body mass index >30 kg/m(2)) were included in our study. We compared the serum level of RBP4 (measured by ELISA) with clinical features (age, sex, BMI, waist-to-hip-ratio, blood pressure) and laboratory findings (total cholesterol, triglycerides, fasting glucose, 2-hour glucose, fasting insulin, HOMA-IR and HOMA-B). The associations between RBP4 and the above mentioned variables were assessed using multiple linear regression models. RESULTS: The mean age (+/-SD) of the subjects included was 48.1 (+/- 12.3) years and the mean BMI 41.6 (+/- 7.4) kg/m(2). We found significantly higher RBP4 levels in men (53.0 +/- 20.8 microg/ml) than in women (39.7 +/- 12.3 microg/ml) (p = 0.0013). However, age and sex-adjusted multiple linear regression models showed no significant association of serum RBP4 levels with BMI, waist-to-hip-ratio, blood pressure, cholesterol, triglycerides, fasting glucose, 2-hour glucose, insulin resistance (as assessed by HOMA-IR), or insulin secretion (as assessed by HOMA-B). CONCLUSION: Our data show higher RBP4 levels in obese men than in obese women. However, there was no association of RBP4 levels with insulin resistance or other components of the metabolic syndrome. We conclude that obesity might already be associated with elevated RBP4 levels which then show no additional correlation with metabolic markers. SN - 1744-4160 UR - https://www.unboundmedicine.com/medline/citation/20222849/Association_of_serum_levels_of_retinol_binding_protein_4_with_male_sex_but_not_with_insulin_resistance_in_obese_patients_ L2 - https://www.tandfonline.com/doi/full/10.3109/13813451003631421 DB - PRIME DP - Unbound Medicine ER -