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pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium.
Int J Biol Macromol. 2010 Jun; 46(5):517-23.IJ

Abstract

In order to enhance the drug entrapment efficiency and improve the swelling behaviors of drug delivery system, Ca2+ crosslinking and freeze-thawing (FT) cycle techniques were used to prepare sodium alginate/poly(vinyl alcohol) (SA/PVA) hydrogel beads. The mixture solution of SA and PVA was firstly crosslinked with Ca2+ to form beads and then subjected to freezing-thawing cycles for further crosslinking. The crosslinking process was confirmed by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The swelling and pH-sensitive properties of the beads were investigated, and the drug loading and controlled release properties of the beads were also evaluated using diclofenac sodium as the model drug. Results indicate that the bead was formed well and the encapsulation efficiency was greatly improved when the ratio of PVA to SA is 3:1. The swelling and degradation of the developed beads was influenced by pH of the test medium and PVA content. FT process enhanced drug entrapment efficiency, improved swelling behaviors and slowed release of drug from the dual crosslinked beads compared with pure SA beads crosslinked with Ca2+ ion alone, which provide a facile and effective method to improve the drug delivery system.

Authors+Show Affiliations

Center for Eco-material and Green Chemistry, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20223260

Citation

Hua, Shuibo, et al. "PH-sensitive Sodium Alginate/poly(vinyl Alcohol) Hydrogel Beads Prepared By Combined Ca2+ Crosslinking and Freeze-thawing Cycles for Controlled Release of Diclofenac Sodium." International Journal of Biological Macromolecules, vol. 46, no. 5, 2010, pp. 517-23.
Hua S, Ma H, Li X, et al. PH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium. Int J Biol Macromol. 2010;46(5):517-23.
Hua, S., Ma, H., Li, X., Yang, H., & Wang, A. (2010). PH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium. International Journal of Biological Macromolecules, 46(5), 517-23. https://doi.org/10.1016/j.ijbiomac.2010.03.004
Hua S, et al. PH-sensitive Sodium Alginate/poly(vinyl Alcohol) Hydrogel Beads Prepared By Combined Ca2+ Crosslinking and Freeze-thawing Cycles for Controlled Release of Diclofenac Sodium. Int J Biol Macromol. 2010;46(5):517-23. PubMed PMID: 20223260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium. AU - Hua,Shuibo, AU - Ma,Haizhen, AU - Li,Xun, AU - Yang,Huixia, AU - Wang,Aiqin, Y1 - 2010/03/16/ PY - 2010/02/03/received PY - 2010/03/02/accepted PY - 2010/3/13/entrez PY - 2010/3/13/pubmed PY - 2010/9/14/medline SP - 517 EP - 23 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 46 IS - 5 N2 - In order to enhance the drug entrapment efficiency and improve the swelling behaviors of drug delivery system, Ca2+ crosslinking and freeze-thawing (FT) cycle techniques were used to prepare sodium alginate/poly(vinyl alcohol) (SA/PVA) hydrogel beads. The mixture solution of SA and PVA was firstly crosslinked with Ca2+ to form beads and then subjected to freezing-thawing cycles for further crosslinking. The crosslinking process was confirmed by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The swelling and pH-sensitive properties of the beads were investigated, and the drug loading and controlled release properties of the beads were also evaluated using diclofenac sodium as the model drug. Results indicate that the bead was formed well and the encapsulation efficiency was greatly improved when the ratio of PVA to SA is 3:1. The swelling and degradation of the developed beads was influenced by pH of the test medium and PVA content. FT process enhanced drug entrapment efficiency, improved swelling behaviors and slowed release of drug from the dual crosslinked beads compared with pure SA beads crosslinked with Ca2+ ion alone, which provide a facile and effective method to improve the drug delivery system. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/20223260/pH_sensitive_sodium_alginate/poly_vinyl_alcohol__hydrogel_beads_prepared_by_combined_Ca2+_crosslinking_and_freeze_thawing_cycles_for_controlled_release_of_diclofenac_sodium_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(10)00085-1 DB - PRIME DP - Unbound Medicine ER -