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Microbial metabolism of cannflavin A and B isolated from Cannabis sativa.
Phytochemistry. 2010 Jun; 71(8-9):1014-9.P

Abstract

Microbial metabolism of cannflavin A (1) and B (2), two biologically active flavonoids isolated from Cannabis sativa L., produced five metabolites (3-7). Incubation of 1 and 2 with Mucor ramannianus (ATCC 9628) and Beauveria bassiana (ATCC 13144), respectively, yielded 6''S,7''-dihydroxycannflavin A (3), 6''S,7''-dihydroxycannflavin A 7-sulfate (4) and 6''S,7''-dihydroxycannflavin A 4'-O-alpha-L-rhamnopyranoside (5), and cannflavin B 7-O-beta-D-4'''-O-methylglucopyranoside (6) and cannflavin B 7-sulfate (7), respectively. All compounds were evaluated for antimicrobial and antiprotozoal activity.

Authors+Show Affiliations

Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20223485

Citation

Ibrahim, Amany K., et al. "Microbial Metabolism of Cannflavin a and B Isolated From Cannabis Sativa." Phytochemistry, vol. 71, no. 8-9, 2010, pp. 1014-9.
Ibrahim AK, Radwan MM, Ahmed SA, et al. Microbial metabolism of cannflavin A and B isolated from Cannabis sativa. Phytochemistry. 2010;71(8-9):1014-9.
Ibrahim, A. K., Radwan, M. M., Ahmed, S. A., Slade, D., Ross, S. A., ElSohly, M. A., & Khan, I. A. (2010). Microbial metabolism of cannflavin A and B isolated from Cannabis sativa. Phytochemistry, 71(8-9), 1014-9. https://doi.org/10.1016/j.phytochem.2010.02.011
Ibrahim AK, et al. Microbial Metabolism of Cannflavin a and B Isolated From Cannabis Sativa. Phytochemistry. 2010;71(8-9):1014-9. PubMed PMID: 20223485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microbial metabolism of cannflavin A and B isolated from Cannabis sativa. AU - Ibrahim,Amany K, AU - Radwan,Mohamed M, AU - Ahmed,Safwat A, AU - Slade,Desmond, AU - Ross,Samir A, AU - ElSohly,Mahmoud A, AU - Khan,Ikhlas A, Y1 - 2010/03/10/ PY - 2009/07/15/received PY - 2010/01/05/revised PY - 2010/02/09/accepted PY - 2010/3/13/entrez PY - 2010/3/13/pubmed PY - 2010/8/7/medline SP - 1014 EP - 9 JF - Phytochemistry JO - Phytochemistry VL - 71 IS - 8-9 N2 - Microbial metabolism of cannflavin A (1) and B (2), two biologically active flavonoids isolated from Cannabis sativa L., produced five metabolites (3-7). Incubation of 1 and 2 with Mucor ramannianus (ATCC 9628) and Beauveria bassiana (ATCC 13144), respectively, yielded 6''S,7''-dihydroxycannflavin A (3), 6''S,7''-dihydroxycannflavin A 7-sulfate (4) and 6''S,7''-dihydroxycannflavin A 4'-O-alpha-L-rhamnopyranoside (5), and cannflavin B 7-O-beta-D-4'''-O-methylglucopyranoside (6) and cannflavin B 7-sulfate (7), respectively. All compounds were evaluated for antimicrobial and antiprotozoal activity. SN - 1873-3700 UR - https://www.unboundmedicine.com/medline/citation/20223485/Microbial_metabolism_of_cannflavin_A_and_B_isolated_from_Cannabis_sativa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9422(10)00055-5 DB - PRIME DP - Unbound Medicine ER -