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Autonomic and cognitive functions in Parkinson's disease (PD).
Arch Gerontol Geriatr. 2011 Jan-Feb; 52(1):84-8.AG

Abstract

We performed this study to evaluate the relationship between the stages of PD and autonomic dysfunction, and to find an association between the autonomic dysfunction and cognitive impairment in PD. Sixty-three patients who met the criteria of the United Kingdom PD Society Brain Bank were enrolled prospectively. Clinical stages were using the Hoehn and Yahr (H&Y) staging and unified PD rating scale motor scores. Cognitive functions were evaluated using the mini-mental state examination (MMSE) and the modified MMSE (3MS) test. The scale for outcome in PD-autonomic (SCOPA-AUT) was used to evaluate autonomic symptoms. Severities of autonomic dysfunction were classified using the composite autonomic scoring scale (CASS). Fifty-four of the 63 patients (86%) had shown abnormalities on CASS. H&Y stages correlated with SCOPA-AUT (p<0.05) and 3MS and MMSE scores (p<0.05). H&Y stages were positively related with autonomic dysfunction, heart rate ratios during deep breathing and the quantitative sudomotor axon reflex test (QSART) scores. Autonomic dysfunction may be present from disease onset, whereas the rate of cognitive decline increases with disease progression. We recommend that both qualitative and quantitative autonomic evaluation from the early stage of disease and regular cognitive screening with disease progression might be useful to facilitate optimal management in PD.

Authors+Show Affiliations

Department of Neurology, Chungnam University Hospital, 640 Daesa-dong Jung-gu, Daejeon 301-721, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20223528

Citation

Oh, Eung Seok, et al. "Autonomic and Cognitive Functions in Parkinson's Disease (PD)." Archives of Gerontology and Geriatrics, vol. 52, no. 1, 2011, pp. 84-8.
Oh ES, Lee JH, Seo JG, et al. Autonomic and cognitive functions in Parkinson's disease (PD). Arch Gerontol Geriatr. 2011;52(1):84-8.
Oh, E. S., Lee, J. H., Seo, J. G., Sohn, E. H., & Lee, A. Y. (2011). Autonomic and cognitive functions in Parkinson's disease (PD). Archives of Gerontology and Geriatrics, 52(1), 84-8. https://doi.org/10.1016/j.archger.2010.02.005
Oh ES, et al. Autonomic and Cognitive Functions in Parkinson's Disease (PD). Arch Gerontol Geriatr. 2011 Jan-Feb;52(1):84-8. PubMed PMID: 20223528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic and cognitive functions in Parkinson's disease (PD). AU - Oh,Eung Seok, AU - Lee,Ji Hee, AU - Seo,Jin Gi, AU - Sohn,Eun Hee, AU - Lee,Ae Young, Y1 - 2010/03/12/ PY - 2009/09/30/received PY - 2010/01/31/revised PY - 2010/02/02/accepted PY - 2010/3/13/entrez PY - 2010/3/13/pubmed PY - 2011/3/19/medline SP - 84 EP - 8 JF - Archives of gerontology and geriatrics JO - Arch Gerontol Geriatr VL - 52 IS - 1 N2 - We performed this study to evaluate the relationship between the stages of PD and autonomic dysfunction, and to find an association between the autonomic dysfunction and cognitive impairment in PD. Sixty-three patients who met the criteria of the United Kingdom PD Society Brain Bank were enrolled prospectively. Clinical stages were using the Hoehn and Yahr (H&Y) staging and unified PD rating scale motor scores. Cognitive functions were evaluated using the mini-mental state examination (MMSE) and the modified MMSE (3MS) test. The scale for outcome in PD-autonomic (SCOPA-AUT) was used to evaluate autonomic symptoms. Severities of autonomic dysfunction were classified using the composite autonomic scoring scale (CASS). Fifty-four of the 63 patients (86%) had shown abnormalities on CASS. H&Y stages correlated with SCOPA-AUT (p<0.05) and 3MS and MMSE scores (p<0.05). H&Y stages were positively related with autonomic dysfunction, heart rate ratios during deep breathing and the quantitative sudomotor axon reflex test (QSART) scores. Autonomic dysfunction may be present from disease onset, whereas the rate of cognitive decline increases with disease progression. We recommend that both qualitative and quantitative autonomic evaluation from the early stage of disease and regular cognitive screening with disease progression might be useful to facilitate optimal management in PD. SN - 1872-6976 UR - https://www.unboundmedicine.com/medline/citation/20223528/Autonomic_and_cognitive_functions_in_Parkinson's_disease__PD__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-4943(10)00040-3 DB - PRIME DP - Unbound Medicine ER -