Tags

Type your tag names separated by a space and hit enter

Assessment of co-existence of Helicobacter pylori and Candida fungi in diseases of the upper gastrointestinal tract.
J Physiol Pharmacol. 2009 Dec; 60 Suppl 6:33-9.JP

Abstract

Candida spp. were found in the gastric mucosa of 27 (17%) patients, out of whom 18 (11%) showed co-existence of the fungi with H. pylori. Analysis of relationship between selected disorders of the upper gastrointestinal tract (non ulcer dyspepsia NUD, gastric ulcer, duodenal ulcer) and infection with H. pylori and/or Candida revealed a link between co-existence of H. pylori with Candida and gastric ulcers suggesting synergism of those microorganism in pathogenesis of the disease. On the contrary, according to quantitative studies performed, the fungi alone do not play a significant role in pathogenesis of the above mentioned disorders as they colonize only epithelium to the extent that is not pathologically significant (<10(3) CFU/ml). Genetical study was carried out on 57 Helicobacter pylori strains isolated from bioptates of the gastric mucosa. The genotypes of the strains (gene cagA and alleles of gene vacA - m1, m2, s1, s2) were determined using the PCR technique. As it was shown, the patients infected with H. pylori strains of genotype cagA+, vacA s1 are exposed to higher risk of peptic ulcer disease (PUD) as compared to the patients infected with cagA-, vacA s2 strains. In the case of the NUD patients a correlation with allele m2 was found only (p<0.001). This may suggest that in future some of the NUD patients infected with cagA+, vacA s1 strains will fall into the group at higher risk for PUD.

Authors+Show Affiliations

Department of Pharmaceutical Microbiology of the Jagiellonian University Medical College, Cracow, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20224149

Citation

Karczewska, E, et al. "Assessment of Co-existence of Helicobacter Pylori and Candida Fungi in Diseases of the Upper Gastrointestinal Tract." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 60 Suppl 6, 2009, pp. 33-9.
Karczewska E, Wojtas I, Sito E, et al. Assessment of co-existence of Helicobacter pylori and Candida fungi in diseases of the upper gastrointestinal tract. J Physiol Pharmacol. 2009;60 Suppl 6:33-9.
Karczewska, E., Wojtas, I., Sito, E., Trojanowska, D., Budak, A., Zwolinska-Wcislo, M., & Wilk, A. (2009). Assessment of co-existence of Helicobacter pylori and Candida fungi in diseases of the upper gastrointestinal tract. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 60 Suppl 6, 33-9.
Karczewska E, et al. Assessment of Co-existence of Helicobacter Pylori and Candida Fungi in Diseases of the Upper Gastrointestinal Tract. J Physiol Pharmacol. 2009;60 Suppl 6:33-9. PubMed PMID: 20224149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of co-existence of Helicobacter pylori and Candida fungi in diseases of the upper gastrointestinal tract. AU - Karczewska,E, AU - Wojtas,I, AU - Sito,E, AU - Trojanowska,D, AU - Budak,A, AU - Zwolinska-Wcislo,M, AU - Wilk,A, PY - 2009/09/09/received PY - 2009/10/30/accepted PY - 2010/3/13/entrez PY - 2010/3/27/pubmed PY - 2010/7/2/medline SP - 33 EP - 9 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J Physiol Pharmacol VL - 60 Suppl 6 N2 - Candida spp. were found in the gastric mucosa of 27 (17%) patients, out of whom 18 (11%) showed co-existence of the fungi with H. pylori. Analysis of relationship between selected disorders of the upper gastrointestinal tract (non ulcer dyspepsia NUD, gastric ulcer, duodenal ulcer) and infection with H. pylori and/or Candida revealed a link between co-existence of H. pylori with Candida and gastric ulcers suggesting synergism of those microorganism in pathogenesis of the disease. On the contrary, according to quantitative studies performed, the fungi alone do not play a significant role in pathogenesis of the above mentioned disorders as they colonize only epithelium to the extent that is not pathologically significant (<10(3) CFU/ml). Genetical study was carried out on 57 Helicobacter pylori strains isolated from bioptates of the gastric mucosa. The genotypes of the strains (gene cagA and alleles of gene vacA - m1, m2, s1, s2) were determined using the PCR technique. As it was shown, the patients infected with H. pylori strains of genotype cagA+, vacA s1 are exposed to higher risk of peptic ulcer disease (PUD) as compared to the patients infected with cagA-, vacA s2 strains. In the case of the NUD patients a correlation with allele m2 was found only (p<0.001). This may suggest that in future some of the NUD patients infected with cagA+, vacA s1 strains will fall into the group at higher risk for PUD. SN - 1899-1505 UR - https://www.unboundmedicine.com/medline/citation/20224149/Assessment_of_co_existence_of_Helicobacter_pylori_and_Candida_fungi_in_diseases_of_the_upper_gastrointestinal_tract_ L2 - https://medlineplus.gov/pepticulcer.html DB - PRIME DP - Unbound Medicine ER -