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[Combined single-day treatment in acute vulvovaginal candidosis].
Akush Ginekol (Sofiia). 2009; 48(6):18-23.AG

Abstract

The aim of this study is to investigate the effectiveness of single-day treatment with oral fluconazole and topical fenticonazole in acute vulvovaginal candidosis (VVC). Infection was proven by detection of yeast cells and pseudohyphae on microscopic examination of vaginal wet smears, by mycological cultures, as well as by the clinical symptoms. The study included 108 patients. Treatment consisted in 150 mg oral Fluconazole and 600 mg topical Fenticonazole. Clinical and mycological examinations were performed on days 0, 7 and 14. The causative yeast fungi were: Candida albicans (83.3%), C. glabrata (11.2%), C. krusei (5.5%). On days 7 and 14 clinical cure rates were found to be 61.5% and 90.7%, while mycological cure rates were 62% and 88.88%, respectively. The above therapeutic regimen was found to be 95.5% effective with C. albicans, 83.3% with C. glabrata and non effective with C. krusei. It is concluded that single-day treatment of acute VVC caused by C. albicans with 150 mg oral fluconazole and 600 mg topical fenticonazole is effective.

Authors

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Pub Type(s)

Journal Article

Language

bul

PubMed ID

20225492

Citation

Kovachev, St, et al. "[Combined Single-day Treatment in Acute Vulvovaginal Candidosis]." Akusherstvo I Ginekologiia, vol. 48, no. 6, 2009, pp. 18-23.
Kovachev S, Nacheva A, Vacheva-Dobrevska R, et al. [Combined single-day treatment in acute vulvovaginal candidosis]. Akush Ginekol (Sofiia). 2009;48(6):18-23.
Kovachev, S., Nacheva, A., Vacheva-Dobrevska, R., & Vasilev, N. (2009). [Combined single-day treatment in acute vulvovaginal candidosis]. Akusherstvo I Ginekologiia, 48(6), 18-23.
Kovachev S, et al. [Combined Single-day Treatment in Acute Vulvovaginal Candidosis]. Akush Ginekol (Sofiia). 2009;48(6):18-23. PubMed PMID: 20225492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Combined single-day treatment in acute vulvovaginal candidosis]. AU - Kovachev,St, AU - Nacheva,A, AU - Vacheva-Dobrevska,R, AU - Vasilev,N, PY - 2010/3/16/entrez PY - 2009/1/1/pubmed PY - 2010/10/6/medline SP - 18 EP - 23 JF - Akusherstvo i ginekologiia JO - Akush Ginekol (Sofiia) VL - 48 IS - 6 N2 - The aim of this study is to investigate the effectiveness of single-day treatment with oral fluconazole and topical fenticonazole in acute vulvovaginal candidosis (VVC). Infection was proven by detection of yeast cells and pseudohyphae on microscopic examination of vaginal wet smears, by mycological cultures, as well as by the clinical symptoms. The study included 108 patients. Treatment consisted in 150 mg oral Fluconazole and 600 mg topical Fenticonazole. Clinical and mycological examinations were performed on days 0, 7 and 14. The causative yeast fungi were: Candida albicans (83.3%), C. glabrata (11.2%), C. krusei (5.5%). On days 7 and 14 clinical cure rates were found to be 61.5% and 90.7%, while mycological cure rates were 62% and 88.88%, respectively. The above therapeutic regimen was found to be 95.5% effective with C. albicans, 83.3% with C. glabrata and non effective with C. krusei. It is concluded that single-day treatment of acute VVC caused by C. albicans with 150 mg oral fluconazole and 600 mg topical fenticonazole is effective. SN - 0324-0959 UR - https://www.unboundmedicine.com/medline/citation/20225492/[Combined_single_day_treatment_in_acute_vulvovaginal_candidosis]_ DB - PRIME DP - Unbound Medicine ER -