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Cytoglobosins A-G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14.
J Nat Prod. 2010 Apr 23; 73(4):729-33.JN

Abstract

Cytoglobosins A-G (1-7), seven new cytochalasan derivatives, along with two structurally related known compounds, isochaetoglobosin D (8) and chaetoglobosin F(ex) (9), were isolated and identified from the cultures of Chaetomium globosum QEN-14, an endophytic fungus derived from the marine green alga Ulva pertusa. The structures of the new natural products as well as their relative configurations were elucidated on the basis of 1D and 2D NMR spectra (COSY, HSQC, HMBC, and NOESY) and HRESIMS data. Cytoglobosins C and D (3 and 4) displayed cytotoxic activity against the A-549 tumor cell line.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Cui CM
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, People's Republic of China.
Li XM
No affiliation info available
Li CS
No affiliation info available
Proksch P
No affiliation info available
Wang BG
No affiliation info available

MeSH

AnimalsChaetomiumChlorophytaDrug Screening Assays, AntitumorHumansIndole AlkaloidsKB CellsLeukemia P388Marine BiologyMiceMolecular StructureNuclear Magnetic Resonance, Biomolecular

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20225834

Citation

Cui, Chuan-Ming, et al. "Cytoglobosins A-G, Cytochalasans From a Marine-derived Endophytic Fungus, Chaetomium Globosum QEN-14." Journal of Natural Products, vol. 73, no. 4, 2010, pp. 729-33.
Cui CM, Li XM, Li CS, et al. Cytoglobosins A-G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14. J Nat Prod. 2010;73(4):729-33.
Cui, C. M., Li, X. M., Li, C. S., Proksch, P., & Wang, B. G. (2010). Cytoglobosins A-G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14. Journal of Natural Products, 73(4), 729-33. https://doi.org/10.1021/np900569t
Cui CM, et al. Cytoglobosins A-G, Cytochalasans From a Marine-derived Endophytic Fungus, Chaetomium Globosum QEN-14. J Nat Prod. 2010 Apr 23;73(4):729-33. PubMed PMID: 20225834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytoglobosins A-G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14. AU - Cui,Chuan-Ming, AU - Li,Xiao-Ming, AU - Li,Chun-Shun, AU - Proksch,Peter, AU - Wang,Bin-Gui, PY - 2010/3/16/entrez PY - 2010/3/17/pubmed PY - 2010/6/4/medline SP - 729 EP - 33 JF - Journal of natural products JO - J Nat Prod VL - 73 IS - 4 N2 - Cytoglobosins A-G (1-7), seven new cytochalasan derivatives, along with two structurally related known compounds, isochaetoglobosin D (8) and chaetoglobosin F(ex) (9), were isolated and identified from the cultures of Chaetomium globosum QEN-14, an endophytic fungus derived from the marine green alga Ulva pertusa. The structures of the new natural products as well as their relative configurations were elucidated on the basis of 1D and 2D NMR spectra (COSY, HSQC, HMBC, and NOESY) and HRESIMS data. Cytoglobosins C and D (3 and 4) displayed cytotoxic activity against the A-549 tumor cell line. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/20225834/Cytoglobosins_A_G_cytochalasans_from_a_marine_derived_endophytic_fungus_Chaetomium_globosum_QEN_14_ L2 - https://doi.org/10.1021/np900569t DB - PRIME DP - Unbound Medicine ER -