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Synthesis, self-assembly, and drug-loading capacity of well-defined cyclodextrin-centered drug-conjugated amphiphilic A(14)B(7) Miktoarm star copolymers based on poly(epsilon-caprolactone) and poly(ethylene glycol).
Biomacromolecules 2010; 11(4):934-43B

Abstract

Novel drug-conjugated amphiphilic A(14)B(7) miktoarm star copolymers composed of 14 poly(epsilon-caprolactone) (PCL) arms and 7 poly(ethylene glycol) (PEG) arms with beta-cyclodextrin (beta-CD) as core moiety were synthesized by the combination of controlled ring-opening polymerization (CROP) and "click" chemistry. (1)H NMR, FT-IR, and SEC-MALLS analyses confirmed the well-defined A(14)B(7) miktoarm star architecture. These amphiphilic miktoarm star copolymers could self-assemble into multimorphological aggregates in aqueous solution, which were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Moreover, the drug-loading efficiency and drug-encapsulation efficiency of the drug-conjugated miktoarm star copolymers were higher than those of the corresponding non-drug-conjugated miktoarm star copolymers.

Authors+Show Affiliations

MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20225892

Citation

Gou, Peng-Fei, et al. "Synthesis, Self-assembly, and Drug-loading Capacity of Well-defined Cyclodextrin-centered Drug-conjugated Amphiphilic A(14)B(7) Miktoarm Star Copolymers Based On Poly(epsilon-caprolactone) and Poly(ethylene Glycol)." Biomacromolecules, vol. 11, no. 4, 2010, pp. 934-43.
Gou PF, Zhu WP, Shen ZQ. Synthesis, self-assembly, and drug-loading capacity of well-defined cyclodextrin-centered drug-conjugated amphiphilic A(14)B(7) Miktoarm star copolymers based on poly(epsilon-caprolactone) and poly(ethylene glycol). Biomacromolecules. 2010;11(4):934-43.
Gou, P. F., Zhu, W. P., & Shen, Z. Q. (2010). Synthesis, self-assembly, and drug-loading capacity of well-defined cyclodextrin-centered drug-conjugated amphiphilic A(14)B(7) Miktoarm star copolymers based on poly(epsilon-caprolactone) and poly(ethylene glycol). Biomacromolecules, 11(4), pp. 934-43. doi:10.1021/bm901371p.
Gou PF, Zhu WP, Shen ZQ. Synthesis, Self-assembly, and Drug-loading Capacity of Well-defined Cyclodextrin-centered Drug-conjugated Amphiphilic A(14)B(7) Miktoarm Star Copolymers Based On Poly(epsilon-caprolactone) and Poly(ethylene Glycol). Biomacromolecules. 2010 Apr 12;11(4):934-43. PubMed PMID: 20225892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis, self-assembly, and drug-loading capacity of well-defined cyclodextrin-centered drug-conjugated amphiphilic A(14)B(7) Miktoarm star copolymers based on poly(epsilon-caprolactone) and poly(ethylene glycol). AU - Gou,Peng-Fei, AU - Zhu,Wei-Pu, AU - Shen,Zhi-Quan, PY - 2010/3/16/entrez PY - 2010/3/17/pubmed PY - 2010/8/6/medline SP - 934 EP - 43 JF - Biomacromolecules JO - Biomacromolecules VL - 11 IS - 4 N2 - Novel drug-conjugated amphiphilic A(14)B(7) miktoarm star copolymers composed of 14 poly(epsilon-caprolactone) (PCL) arms and 7 poly(ethylene glycol) (PEG) arms with beta-cyclodextrin (beta-CD) as core moiety were synthesized by the combination of controlled ring-opening polymerization (CROP) and "click" chemistry. (1)H NMR, FT-IR, and SEC-MALLS analyses confirmed the well-defined A(14)B(7) miktoarm star architecture. These amphiphilic miktoarm star copolymers could self-assemble into multimorphological aggregates in aqueous solution, which were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Moreover, the drug-loading efficiency and drug-encapsulation efficiency of the drug-conjugated miktoarm star copolymers were higher than those of the corresponding non-drug-conjugated miktoarm star copolymers. SN - 1526-4602 UR - https://www.unboundmedicine.com/medline/citation/20225892/Synthesis_self_assembly_and_drug_loading_capacity_of_well_defined_cyclodextrin_centered_drug_conjugated_amphiphilic_A_14_B_7__Miktoarm_star_copolymers_based_on_poly_epsilon_caprolactone__and_poly_ethylene_glycol__ L2 - https://dx.doi.org/10.1021/bm901371p DB - PRIME DP - Unbound Medicine ER -