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Efficacy of vancomycin and daptomycin against Staphylococcus aureus isolates collected over 29 years.
Diagn Microbiol Infect Dis. 2010 Apr; 66(4):441-4.DM

Abstract

We investigated vancomycin and daptomycin efficacy for Staphylococcus aureus isolates at our institution by testing 221 methicillin-sensitive and 299 methicillin-resistant isolates recovered from serious infections between 1979 and 2007 using a microdilution method. The MIC(90)'s for vancomycin remained constant at 2 microg/mL for methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA). For MSSA, the geometric mean vancomycin MICs remained at 1.1 microg/mL but varied from 1.1 to 1.7 for MRSA. Tolerance to vancomycin was seen in 6.5% of MRSA and 10.5% of MSSA. Daptomycin MIC(90)'s remained at < or =1 microg/mL, and the daptomycin concentration at which 90% of the strains were killed (MBC(90)) remained at 2 microg/ml. Over 29 years, no trend was detected in vancomycin or daptomycin susceptibilities. Daptomycin had excellent inhibitory and bactericidal activities against all strains throughout the years. Although vancomycin's inhibitory activity was consistent over time, vancomycin-tolerant strains whose presence was not predicted by their MIC were found.

Authors+Show Affiliations

Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. mapplema@usc.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20226335

Citation

Appleman, Maria D., and Diane M. Citron. "Efficacy of Vancomycin and Daptomycin Against Staphylococcus Aureus Isolates Collected Over 29 Years." Diagnostic Microbiology and Infectious Disease, vol. 66, no. 4, 2010, pp. 441-4.
Appleman MD, Citron DM. Efficacy of vancomycin and daptomycin against Staphylococcus aureus isolates collected over 29 years. Diagn Microbiol Infect Dis. 2010;66(4):441-4.
Appleman, M. D., & Citron, D. M. (2010). Efficacy of vancomycin and daptomycin against Staphylococcus aureus isolates collected over 29 years. Diagnostic Microbiology and Infectious Disease, 66(4), 441-4. https://doi.org/10.1016/j.diagmicrobio.2009.11.008
Appleman MD, Citron DM. Efficacy of Vancomycin and Daptomycin Against Staphylococcus Aureus Isolates Collected Over 29 Years. Diagn Microbiol Infect Dis. 2010;66(4):441-4. PubMed PMID: 20226335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of vancomycin and daptomycin against Staphylococcus aureus isolates collected over 29 years. AU - Appleman,Maria D, AU - Citron,Diane M, PY - 2009/06/28/received PY - 2009/11/07/revised PY - 2009/11/15/accepted PY - 2010/3/16/entrez PY - 2010/3/17/pubmed PY - 2010/5/26/medline SP - 441 EP - 4 JF - Diagnostic microbiology and infectious disease JO - Diagn Microbiol Infect Dis VL - 66 IS - 4 N2 - We investigated vancomycin and daptomycin efficacy for Staphylococcus aureus isolates at our institution by testing 221 methicillin-sensitive and 299 methicillin-resistant isolates recovered from serious infections between 1979 and 2007 using a microdilution method. The MIC(90)'s for vancomycin remained constant at 2 microg/mL for methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA). For MSSA, the geometric mean vancomycin MICs remained at 1.1 microg/mL but varied from 1.1 to 1.7 for MRSA. Tolerance to vancomycin was seen in 6.5% of MRSA and 10.5% of MSSA. Daptomycin MIC(90)'s remained at < or =1 microg/mL, and the daptomycin concentration at which 90% of the strains were killed (MBC(90)) remained at 2 microg/ml. Over 29 years, no trend was detected in vancomycin or daptomycin susceptibilities. Daptomycin had excellent inhibitory and bactericidal activities against all strains throughout the years. Although vancomycin's inhibitory activity was consistent over time, vancomycin-tolerant strains whose presence was not predicted by their MIC were found. SN - 1879-0070 UR - https://www.unboundmedicine.com/medline/citation/20226335/Efficacy_of_vancomycin_and_daptomycin_against_Staphylococcus_aureus_isolates_collected_over_29_years_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0732-8893(09)00470-2 DB - PRIME DP - Unbound Medicine ER -