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Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis.
Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun; 82(4-6):273-6.PL

Abstract

Dietary requirements for maintaining brain and heart docosahexaenoic acid (DHA, 22:6n-3) homeostasis are not agreed on, in part because rates of liver DHA synthesis from circulating alpha-linolenic acid (alpha-LNA, 18:3n-3) have not been quantified. These rates can be estimated using intravenous radiotracer- or heavy isotope-labeled alpha-LNA infusion. In adult unanesthetized male rats, such infusion shows that liver synthesis-secretion rates of DHA from alpha-LNA markedly exceed brain and heart DHA synthesis rates and the brain DHA consumption rate, and that liver but not heart or brain synthesis is upregulated when dietary n-3 PUFA content is reduced. These rate differences reflect much higher expression of DHA-synthesizing enzymes in liver, and upregulation of liver but not heart or brain enzyme expression by reduced dietary n-3 PUFA content. A noninvasive intravenous [U-(13)C]alpha-LNA infusion method that produces steady-state liver tracer metabolism gives exact liver DHA synthesis-secretion rates and could be extended for human studies.

Authors+Show Affiliations

Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. sir@helix.nih.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural
Review

Language

eng

PubMed ID

20226642

Citation

Rapoport, Stanley I., et al. "Quantitative Contributions of Diet and Liver Synthesis to Docosahexaenoic Acid Homeostasis." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 82, no. 4-6, 2010, pp. 273-6.
Rapoport SI, Igarashi M, Gao F. Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis. Prostaglandins Leukot Essent Fatty Acids. 2010;82(4-6):273-6.
Rapoport, S. I., Igarashi, M., & Gao, F. (2010). Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 82(4-6), 273-6. https://doi.org/10.1016/j.plefa.2010.02.015
Rapoport SI, Igarashi M, Gao F. Quantitative Contributions of Diet and Liver Synthesis to Docosahexaenoic Acid Homeostasis. Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):273-6. PubMed PMID: 20226642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis. AU - Rapoport,Stanley I, AU - Igarashi,Miki, AU - Gao,Fei, Y1 - 2010/03/12/ PY - 2010/3/16/entrez PY - 2010/3/17/pubmed PY - 2010/8/12/medline SP - 273 EP - 6 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 82 IS - 4-6 N2 - Dietary requirements for maintaining brain and heart docosahexaenoic acid (DHA, 22:6n-3) homeostasis are not agreed on, in part because rates of liver DHA synthesis from circulating alpha-linolenic acid (alpha-LNA, 18:3n-3) have not been quantified. These rates can be estimated using intravenous radiotracer- or heavy isotope-labeled alpha-LNA infusion. In adult unanesthetized male rats, such infusion shows that liver synthesis-secretion rates of DHA from alpha-LNA markedly exceed brain and heart DHA synthesis rates and the brain DHA consumption rate, and that liver but not heart or brain synthesis is upregulated when dietary n-3 PUFA content is reduced. These rate differences reflect much higher expression of DHA-synthesizing enzymes in liver, and upregulation of liver but not heart or brain enzyme expression by reduced dietary n-3 PUFA content. A noninvasive intravenous [U-(13)C]alpha-LNA infusion method that produces steady-state liver tracer metabolism gives exact liver DHA synthesis-secretion rates and could be extended for human studies. SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/20226642/Quantitative_contributions_of_diet_and_liver_synthesis_to_docosahexaenoic_acid_homeostasis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(10)00059-1 DB - PRIME DP - Unbound Medicine ER -