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Morphine-induced impairment of spatial memory acquisition reversed by morphine sensitization in rats.
Behav Brain Res. 2010 Aug 25; 211(2):156-63.BB

Abstract

In the present study, the effects of systemic administration of morphine on spatial memory acquisition of a Morris water maze (MWM) task have been investigated in morphine-sensitized rats. Sensitization was obtained by subcutaneous (s.c.) injection of morphine, once daily for 3 days followed by 5 days free of the opioid before training. Then the rats were trained in the water maze task which was consisted of single training session of 8 trials and 24 h later a probe trial consist of 60 s free swim period without a platform and then non-spatial visual discrimination task was done. Our data indicated that pre-training single administration of morphine (2.5, 5 and 7.5 mg/kg) decreased the spatial memory acquisition in Morris water maze task with a maximum effect of 5 mg/kg of morphine. Amnesia induced by pre-training morphine was significantly reversed in morphine-sensitized (15 and 20 mg/kg) rats. The inhibition of morphine-induced amnesia in morphine-sensitized rats was decreased by once daily administration of naloxone (1 and 2 mg/kg) 30 min prior to injection of morphine during sensitization. The results suggest that morphine sensitization reverses the impairment of spatial memory acquisition induced by morphine and it is postulated that opioid receptors may play an important role in this effect.

Authors+Show Affiliations

Department of Physiology, Tehran University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20226816

Citation

Farahmandfar, Maryam, et al. "Morphine-induced Impairment of Spatial Memory Acquisition Reversed By Morphine Sensitization in Rats." Behavioural Brain Research, vol. 211, no. 2, 2010, pp. 156-63.
Farahmandfar M, Karimian SM, Naghdi N, et al. Morphine-induced impairment of spatial memory acquisition reversed by morphine sensitization in rats. Behav Brain Res. 2010;211(2):156-63.
Farahmandfar, M., Karimian, S. M., Naghdi, N., Zarrindast, M. R., & Kadivar, M. (2010). Morphine-induced impairment of spatial memory acquisition reversed by morphine sensitization in rats. Behavioural Brain Research, 211(2), 156-63. https://doi.org/10.1016/j.bbr.2010.03.013
Farahmandfar M, et al. Morphine-induced Impairment of Spatial Memory Acquisition Reversed By Morphine Sensitization in Rats. Behav Brain Res. 2010 Aug 25;211(2):156-63. PubMed PMID: 20226816.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphine-induced impairment of spatial memory acquisition reversed by morphine sensitization in rats. AU - Farahmandfar,Maryam, AU - Karimian,Seyed Morteza, AU - Naghdi,Nasser, AU - Zarrindast,Mohammad-Reza, AU - Kadivar,Mehdi, Y1 - 2010/03/11/ PY - 2010/01/06/received PY - 2010/02/28/revised PY - 2010/03/05/accepted PY - 2010/3/16/entrez PY - 2010/3/17/pubmed PY - 2010/8/4/medline SP - 156 EP - 63 JF - Behavioural brain research JO - Behav Brain Res VL - 211 IS - 2 N2 - In the present study, the effects of systemic administration of morphine on spatial memory acquisition of a Morris water maze (MWM) task have been investigated in morphine-sensitized rats. Sensitization was obtained by subcutaneous (s.c.) injection of morphine, once daily for 3 days followed by 5 days free of the opioid before training. Then the rats were trained in the water maze task which was consisted of single training session of 8 trials and 24 h later a probe trial consist of 60 s free swim period without a platform and then non-spatial visual discrimination task was done. Our data indicated that pre-training single administration of morphine (2.5, 5 and 7.5 mg/kg) decreased the spatial memory acquisition in Morris water maze task with a maximum effect of 5 mg/kg of morphine. Amnesia induced by pre-training morphine was significantly reversed in morphine-sensitized (15 and 20 mg/kg) rats. The inhibition of morphine-induced amnesia in morphine-sensitized rats was decreased by once daily administration of naloxone (1 and 2 mg/kg) 30 min prior to injection of morphine during sensitization. The results suggest that morphine sensitization reverses the impairment of spatial memory acquisition induced by morphine and it is postulated that opioid receptors may play an important role in this effect. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/20226816/Morphine_induced_impairment_of_spatial_memory_acquisition_reversed_by_morphine_sensitization_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(10)00183-X DB - PRIME DP - Unbound Medicine ER -