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Atorvastatin increases blood ratios of vitamin E/low-density lipoprotein cholesterol and coenzyme Q10/low-density lipoprotein cholesterol in hypercholesterolemic patients.
Nutr Res. 2010 Feb; 30(2):118-24.NR

Abstract

Statins are among the most widely used drugs in the management of hypercholesterolemia. In addition to inhibiting endogenous cholesterol synthesis, however, statins decrease coenzyme Q10 (CoQ10) synthesis. CoQ10 has been reported to have antioxidant properties, and administration of drugs that decrease CoQ10 synthesis might lead to increased oxidative stress in vivo. Our present study examined the hypothesis that atorvastatin increased oxidative stress in hypercholesterolemic patients due to its inhibition of CoQ10 synthesis. We investigated the effects of atorvastatin (10 mg/d) administration for 5 months on lowering hypercholesterolemia and blood antioxidant status. The study population included 19 hypercholesterolemic outpatients. Blood levels of lipid and antioxidant markers, consisting of vitamin C, vitamin E, CoQ10, and glutathione (GSH), and urinary levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) were examined pre- and postadministration of atorvastatin. Atorvastatin administration resulted in a significant decrease in blood levels of total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, vitamin E, and CoQ10 (P < .05); however, a significant increase in the ratios of vitamin E/LDL cholesterol and CoQ10/LDL cholesterol was noted (P < .05). Atorvastatin had no significant effect on red blood cell (RBC) level of GSH and urinary 8-OHdG. The present study provides evidence that atorvastatin exerts a hypocholesterolemic effect, but on the basis of the urinary level of 8-OHdG and the blood ratios of vitamin E/LDL cholesterol and CoQ10/LDL cholesterol, has no oxidative stress-inducing effect.

Authors+Show Affiliations

Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20226997

Citation

Liu, Chin-San, et al. "Atorvastatin Increases Blood Ratios of Vitamin E/low-density Lipoprotein Cholesterol and Coenzyme Q10/low-density Lipoprotein Cholesterol in Hypercholesterolemic Patients." Nutrition Research (New York, N.Y.), vol. 30, no. 2, 2010, pp. 118-24.
Liu CS, Lii CK, Chang LL, et al. Atorvastatin increases blood ratios of vitamin E/low-density lipoprotein cholesterol and coenzyme Q10/low-density lipoprotein cholesterol in hypercholesterolemic patients. Nutr Res. 2010;30(2):118-24.
Liu, C. S., Lii, C. K., Chang, L. L., Kuo, C. L., Cheng, W. L., Su, S. L., Tsai, C. W., & Chen, H. W. (2010). Atorvastatin increases blood ratios of vitamin E/low-density lipoprotein cholesterol and coenzyme Q10/low-density lipoprotein cholesterol in hypercholesterolemic patients. Nutrition Research (New York, N.Y.), 30(2), 118-24. https://doi.org/10.1016/j.nutres.2010.01.007
Liu CS, et al. Atorvastatin Increases Blood Ratios of Vitamin E/low-density Lipoprotein Cholesterol and Coenzyme Q10/low-density Lipoprotein Cholesterol in Hypercholesterolemic Patients. Nutr Res. 2010;30(2):118-24. PubMed PMID: 20226997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atorvastatin increases blood ratios of vitamin E/low-density lipoprotein cholesterol and coenzyme Q10/low-density lipoprotein cholesterol in hypercholesterolemic patients. AU - Liu,Chin-San, AU - Lii,Chong-Kuei, AU - Chang,Li-Ling, AU - Kuo,Chen-Ling, AU - Cheng,Wen-Ling, AU - Su,Shih-Li, AU - Tsai,Chia-Wen, AU - Chen,Haw-Wen, PY - 2009/10/28/received PY - 2010/01/07/revised PY - 2010/01/21/accepted PY - 2010/3/16/entrez PY - 2010/3/17/pubmed PY - 2010/8/5/medline SP - 118 EP - 24 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 30 IS - 2 N2 - Statins are among the most widely used drugs in the management of hypercholesterolemia. In addition to inhibiting endogenous cholesterol synthesis, however, statins decrease coenzyme Q10 (CoQ10) synthesis. CoQ10 has been reported to have antioxidant properties, and administration of drugs that decrease CoQ10 synthesis might lead to increased oxidative stress in vivo. Our present study examined the hypothesis that atorvastatin increased oxidative stress in hypercholesterolemic patients due to its inhibition of CoQ10 synthesis. We investigated the effects of atorvastatin (10 mg/d) administration for 5 months on lowering hypercholesterolemia and blood antioxidant status. The study population included 19 hypercholesterolemic outpatients. Blood levels of lipid and antioxidant markers, consisting of vitamin C, vitamin E, CoQ10, and glutathione (GSH), and urinary levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) were examined pre- and postadministration of atorvastatin. Atorvastatin administration resulted in a significant decrease in blood levels of total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, vitamin E, and CoQ10 (P < .05); however, a significant increase in the ratios of vitamin E/LDL cholesterol and CoQ10/LDL cholesterol was noted (P < .05). Atorvastatin had no significant effect on red blood cell (RBC) level of GSH and urinary 8-OHdG. The present study provides evidence that atorvastatin exerts a hypocholesterolemic effect, but on the basis of the urinary level of 8-OHdG and the blood ratios of vitamin E/LDL cholesterol and CoQ10/LDL cholesterol, has no oxidative stress-inducing effect. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/20226997/Atorvastatin_increases_blood_ratios_of_vitamin_E/low_density_lipoprotein_cholesterol_and_coenzyme_Q10/low_density_lipoprotein_cholesterol_in_hypercholesterolemic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(10)00018-7 DB - PRIME DP - Unbound Medicine ER -