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Surveillance and characterization of low pathogenic H5 avian influenza viruses isolated from wild migratory birds in Korea.
Virus Res. 2010 Jun; 150(1-2):119-28.VR

Abstract

Migratory waterfowls are the natural reservoir of influenza A viruses. However, interspecies transmission had occasionally caused outbreaks in various hosts including humans. To characterize the genetic origins of H5 avian influenza viruses isolated from migratory birds in South Korea, phylogenetic analysis were conducted. A total of 53 H5 viruses were isolated between October 2005 and November 2008. Full genetic characterization indicated that most of these viruses belong to the Eurasian-like avian lineage. However, some segments of the AB/Korea/W235/07 and the AB/Korea/W236/07 isolates were clustered with North American lineage viruses rather than those of the Eurasian lineage, suggesting the occurrence of reassortment between these two avian virus lineages. Phylogenetic analysis further demonstrated that the H5N2 and H5N3 virus isolates were of the low pathogenicity H5 phenotype. The H5 viruses appear to be antigenically similar to each other, but could be distinguished from a recent HPAI H5N1 (EM/Korea/W149/06) virus by hemagglutinin inhibition (HI) assays. Experimental inoculation of representative viruses indicated that certain isolates, particularly AB/Korea/W163/07 (H5N2), could be detected in trachea and lungs of chickens but none could be transmitted by direct contact. Furthermore, all of the viruses could be detected in mice lung without prior adaptation which is indicative of their pathogenic potential in a mammalian host. Overall, our results emphasize the important role that migratory birds play in the perpetuation, transport, and reassortment of avian influenza viruses stressing the need for continued surveillance of influenza virus activity in these avian populations.

Authors+Show Affiliations

College of Medicine and Medical Research Institute, Chungbuk National University, 12 Gaeshin-Dong, Heungduk-Ku, Cheongju 361-763, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20227447

Citation

Baek, Yun Hee, et al. "Surveillance and Characterization of Low Pathogenic H5 Avian Influenza Viruses Isolated From Wild Migratory Birds in Korea." Virus Research, vol. 150, no. 1-2, 2010, pp. 119-28.
Baek YH, Pascua PN, Song MS, et al. Surveillance and characterization of low pathogenic H5 avian influenza viruses isolated from wild migratory birds in Korea. Virus Res. 2010;150(1-2):119-28.
Baek, Y. H., Pascua, P. N., Song, M. S., Park, K. J., Kwon, H. I., Lee, J. H., Kim, S. Y., Moon, H. J., Kim, C. J., & Choi, Y. K. (2010). Surveillance and characterization of low pathogenic H5 avian influenza viruses isolated from wild migratory birds in Korea. Virus Research, 150(1-2), 119-28. https://doi.org/10.1016/j.virusres.2010.03.002
Baek YH, et al. Surveillance and Characterization of Low Pathogenic H5 Avian Influenza Viruses Isolated From Wild Migratory Birds in Korea. Virus Res. 2010;150(1-2):119-28. PubMed PMID: 20227447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surveillance and characterization of low pathogenic H5 avian influenza viruses isolated from wild migratory birds in Korea. AU - Baek,Yun Hee, AU - Pascua,Philippe Noriel Q, AU - Song,Min-Suk, AU - Park,Kuk Jin, AU - Kwon,Hyeok-il, AU - Lee,Jun Han, AU - Kim,Seok-Yong, AU - Moon,Ho-Jin, AU - Kim,Chul-Joong, AU - Choi,Young Ki, Y1 - 2010/03/21/ PY - 2009/12/22/received PY - 2010/03/03/revised PY - 2010/03/04/accepted PY - 2010/3/16/entrez PY - 2010/3/17/pubmed PY - 2010/7/20/medline SP - 119 EP - 28 JF - Virus research JO - Virus Res VL - 150 IS - 1-2 N2 - Migratory waterfowls are the natural reservoir of influenza A viruses. However, interspecies transmission had occasionally caused outbreaks in various hosts including humans. To characterize the genetic origins of H5 avian influenza viruses isolated from migratory birds in South Korea, phylogenetic analysis were conducted. A total of 53 H5 viruses were isolated between October 2005 and November 2008. Full genetic characterization indicated that most of these viruses belong to the Eurasian-like avian lineage. However, some segments of the AB/Korea/W235/07 and the AB/Korea/W236/07 isolates were clustered with North American lineage viruses rather than those of the Eurasian lineage, suggesting the occurrence of reassortment between these two avian virus lineages. Phylogenetic analysis further demonstrated that the H5N2 and H5N3 virus isolates were of the low pathogenicity H5 phenotype. The H5 viruses appear to be antigenically similar to each other, but could be distinguished from a recent HPAI H5N1 (EM/Korea/W149/06) virus by hemagglutinin inhibition (HI) assays. Experimental inoculation of representative viruses indicated that certain isolates, particularly AB/Korea/W163/07 (H5N2), could be detected in trachea and lungs of chickens but none could be transmitted by direct contact. Furthermore, all of the viruses could be detected in mice lung without prior adaptation which is indicative of their pathogenic potential in a mammalian host. Overall, our results emphasize the important role that migratory birds play in the perpetuation, transport, and reassortment of avian influenza viruses stressing the need for continued surveillance of influenza virus activity in these avian populations. SN - 1872-7492 UR - https://www.unboundmedicine.com/medline/citation/20227447/Surveillance_and_characterization_of_low_pathogenic_H5_avian_influenza_viruses_isolated_from_wild_migratory_birds_in_Korea_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-1702(10)00102-4 DB - PRIME DP - Unbound Medicine ER -