Tags

Type your tag names separated by a space and hit enter

Diet and prostate cancer risk with specific focus on dairy products and dietary calcium: a case-control study.
Prostate 2010; 70(10):1054-65P

Abstract

BACKGROUND

Despite the prevalence of prostate cancer worldwide, only a few risk factors have been well-established. The role of diet, especially of dairy products, in the etiology of prostate cancer is still controversial.

METHODS

This study assessed the association of dietary components, particularly dairy products and dietary calcium, on prostate cancer risk in a case-control study of 197 cases and an equal number of individually matched controls recruited in Montreal, Canada. A semi-quantitative food frequency questionnaire was administered in which the usual consumption frequency and amounts consumed of more than 200 food items were recorded.

RESULTS

We found a twofold increased risk of prostate cancer associated with an increased intake of dairy products {Odds Ratio (OR) = 2.19; 95% Confidence Intervals (CI) 1.22-3.94}. A significant trend of decreasing prostate cancer risk with higher intake was found for legumes, nuts, finfish/shellfish and for alpha-tocopherol after adjustment for calcium intake. Milk was the only dairy product significantly associated with prostate cancer risk, with OR = 2.27; 95% CI (1.25-4.09) for the highest versus lowest quartiles of consumption. Calcium, the main micronutrient contained in dairy products, showed only a borderline association with prostate cancer risk (P = 0.09), with slightly higher risk for higher calcium intake. In conclusion, this study supports the hypothesis that dairy products, especially milk, are involved in the etiology of prostate cancer. However, the mechanisms by which the various nutrients in dairy products and total diet may interact to influence this risk remain unknown.

Authors+Show Affiliations

Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20232354

Citation

Raimondi, Sara, et al. "Diet and Prostate Cancer Risk With Specific Focus On Dairy Products and Dietary Calcium: a Case-control Study." The Prostate, vol. 70, no. 10, 2010, pp. 1054-65.
Raimondi S, Mabrouk JB, Shatenstein B, et al. Diet and prostate cancer risk with specific focus on dairy products and dietary calcium: a case-control study. Prostate. 2010;70(10):1054-65.
Raimondi, S., Mabrouk, J. B., Shatenstein, B., Maisonneuve, P., & Ghadirian, P. (2010). Diet and prostate cancer risk with specific focus on dairy products and dietary calcium: a case-control study. The Prostate, 70(10), pp. 1054-65. doi:10.1002/pros.21139.
Raimondi S, et al. Diet and Prostate Cancer Risk With Specific Focus On Dairy Products and Dietary Calcium: a Case-control Study. Prostate. 2010 Jul 1;70(10):1054-65. PubMed PMID: 20232354.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet and prostate cancer risk with specific focus on dairy products and dietary calcium: a case-control study. AU - Raimondi,Sara, AU - Mabrouk,Jihène Ben, AU - Shatenstein,Bryna, AU - Maisonneuve,Patrick, AU - Ghadirian,Parviz, PY - 2010/3/17/entrez PY - 2010/3/17/pubmed PY - 2010/6/16/medline SP - 1054 EP - 65 JF - The Prostate JO - Prostate VL - 70 IS - 10 N2 - BACKGROUND: Despite the prevalence of prostate cancer worldwide, only a few risk factors have been well-established. The role of diet, especially of dairy products, in the etiology of prostate cancer is still controversial. METHODS: This study assessed the association of dietary components, particularly dairy products and dietary calcium, on prostate cancer risk in a case-control study of 197 cases and an equal number of individually matched controls recruited in Montreal, Canada. A semi-quantitative food frequency questionnaire was administered in which the usual consumption frequency and amounts consumed of more than 200 food items were recorded. RESULTS: We found a twofold increased risk of prostate cancer associated with an increased intake of dairy products {Odds Ratio (OR) = 2.19; 95% Confidence Intervals (CI) 1.22-3.94}. A significant trend of decreasing prostate cancer risk with higher intake was found for legumes, nuts, finfish/shellfish and for alpha-tocopherol after adjustment for calcium intake. Milk was the only dairy product significantly associated with prostate cancer risk, with OR = 2.27; 95% CI (1.25-4.09) for the highest versus lowest quartiles of consumption. Calcium, the main micronutrient contained in dairy products, showed only a borderline association with prostate cancer risk (P = 0.09), with slightly higher risk for higher calcium intake. In conclusion, this study supports the hypothesis that dairy products, especially milk, are involved in the etiology of prostate cancer. However, the mechanisms by which the various nutrients in dairy products and total diet may interact to influence this risk remain unknown. SN - 1097-0045 UR - https://www.unboundmedicine.com/medline/citation/20232354/Diet_and_prostate_cancer_risk_with_specific_focus_on_dairy_products_and_dietary_calcium:_a_case_control_study_ L2 - https://doi.org/10.1002/pros.21139 DB - PRIME DP - Unbound Medicine ER -